In addition to Cummings, who will serve as principalinvestigator, personnel for the NCFG also include David F. Smith, Ph.D.,technical director and professor of biochemistry; Tongzhong Ju, M.D., Ph.D.,project leader and associate professor of biochemistry; Xuezheng Song, Ph.D.,project leader and assistant professor of biochemistry; and JamieHeimburg-Molinaro, Ph.D., project coordinator.
This grant from the NIH will be used to fund research intothe recognition of glycans and complex carbohydrates through the use of "glycanmicroarrays," platforms that contain microscopic outlays of diverse glycansthat might be recognized by antibodies, proteins, viruses and bacteria. Inaddition to this work, the NCFG will specifically focus on developingtechnology for the glycosciences, particularly to aid in exploring themolecular mechanisms of glycan recognition by proteins within the body thatplay roles in human biology and disease.
Glycans are polysaccharides or oligosaccharides, and theglycans found on glycoproteins and glycolipids and in body fluids represent theglycome, which is similar to the genome and the proteome. Changes inglycosylation—the process in which glycans are attached to proteins, lipids orother molecules—play a role in numerous diseases and conditions, such ascancer, cystic fibrosis, inflammation and congenital disorders ofglycosylation. Glycans on human cells are bound by viruses and bacteria thatconsist of the frontrunners in invasion and infection.
SOURCE: Emory University press release