Modeling Neural Diseases In Vitro
Neural cell culture models mimic the brain microenvironment and provide physiologically relevant information for drug discovery.
Neuroscience
The burden of stem cell mutations
A new analysis shows huge variation in mutations for induced pluripotent stem cells, including some changes that can severely limit their ability to transform into other kinds of cells.
T cell memory tips off early stages of Parkinson’s disease
T cells that react to a Parkinson’s disease-linked protein have an early, unique, and detectable gene signature.
Digital technology reveals the secrets to treating neurological disorders
A biotech start-up teamed up with technology giants like Apple to continuously monitor people with Parkinson’s disease so that they could personalize their treatments in the clinic and the lab.
Patient cells and serum create better Alzheimer’s disease models
Many potential treatments for Alzheimer’s disease have been found using mouse models, but they often don’t translate well to humans. Will organoids provide the answers that neuroscientists need to develop new treatments?
From Honeybees to Humans: Imaging gene expression in the brain
Entomologists and computer engineers developed a novel imaging method for analyzing gene expression in live brains.
Misbehaving mitochondria may contribute to conditions such as autism
Mitochondria fragment and fuse to meet the energetic needs of the cell. Research shows that poorly regulated mitochondrial dynamics contribute to conditions such as autism.
How Microbes Drive Brain Disorders
Studying complex gut microbial biology reveals insights into the progression of brain disorders.
Seminar summary: Delivering drugs to the brain
Scientists and clinicians discussed their solutions for overcoming the challenge of getting past the blood-brain barrier in DDN’s first seminar.
An infective spark for Alzheimer's disease
A once fringe theory that viral and bacterial infections trigger the neuroinflammation and cognitive decline associated with Alzheimer’s disease is gaining traction. If it proves true, available antimicrobials could be a long sought-after treatment for this neurodegenerative disease.
