Register for free to listen to this article
Listen with Speechify
0:00
1:00
Sartorius Stedim Biotech
 

Sartorius Stedim Biotech has launched the first commerciallyavailable membrane adsorber for hydrophobic interaction chromatography (HIC).Sartobind Phenyl membrane adsorbers allow increased flow rates to ensure fasterprocesses and can be used for process upgrades in purification and polishing oftherapeutic proteins. Sartobind Phenyl provides the advantages of an HIC ligandadsorber while showing the specificity and behavior of a conventional HICmatrix. The hydrophobic phenyl ligand is covalently attached to the >3 µmcellulose membrane. Target molecules bind to the membrane with similar bindingcapacities and at the same buffer conditions as with conventional HIC columns.However, the flow rates can be increased at least tenfold to allow a fasterprocess upgrade in purification and polishing of therapeutic proteins. Theresolution is at least as good as that obtained with comparable phenyl columns.With a binding capacity of 0.4 mg/cm² (15 mg/ml), Sartobind Phenyl can be usedfor antibody medium scale capture. Its key application is removal ofhydrophobic aggregates that pose the risk of unwanted immune system responsewhen patients are treated with therapeutic proteins. Detergent removal andlarge molecule /bioparticle purification are further application options forHIC membranes. The membrane adsorber is easy to handle, suitable for single andbatch use and scalable from the 3 ml Sartobind nano version to the Sartobind150 ml capsule. It will soon also be scalable to the Jumbo 5 l unit.
 


Sartorius Stedim Biotech
 

Related Topics

Published In

Loading Next Article...
Loading Next Article...
Subscribe to Newsletter

Subscribe to our eNewsletters

Stay connected with all of the latest from Drug Discovery News.

Subscribe

Sponsored

GreenCooling

Thermo Scientific™ Centrifuges with GreenCool Technology

Next-generation natural refrigerant cooling system for centrifuges, offering a lower Global Warming Potential and reduced energy consumption.
Clear sample tubes are shown in a clear tote with red lids in a sample prep robot with a blue and silver industrial lab background.

The crucial role of sample preparation in biotherapy manufacturing

Discover how better sample preparation can unlock improved assay accuracy and analytical results.
A black mosquito is shown on pink human skin against a blurred green backdrop.

Discovering deeper insights into malaria research

Malaria continues to drive urgent research worldwide, with new therapies and tools emerging to combat the parasite’s complex lifecycle and global burden.
Drug Discovery News March 2025 Issue
Latest IssueVolume 21 • Issue 1 • March 2025

March 2025

March 2025 Issue

Explore this issue