Article

Making induced pluripotent stem cells universal

Scientists developed hypoimmune induced pluripotent stem cells to reduce the risk of immune rejection and immunogenicity during cell therapy.

Induced pluripotent stem cells (iPSCs), differentiated cells reprogrammed into a stem cell-like state, hold promise for precision medicine, but they may also serve as a renewable source for off-the-shelf cell therapies. This approach would allow researchers to take ready-made iPSCs and genetically manipulate them to treat different diseases. However, transplanting these cells still carries the risk of immune rejection.

Download this research summary from Bio-Techne to learn how a team of scientists generated immunologically undetectable iPSCs for large-scale manufacturing of universally compatible cell therapies.

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