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December 2025

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September 2025

Ryan Larson smiles wearing a blue, white, and brown checkered shirt with his arms crossed.

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A rendering of a CAR T cell on a dark blue background.

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Two ongoing Phase 1 trials will produce the first human data on these potentially revolutionary cancer drugs.

New clinical trial puts&nbsp;<em data-start="217" data-end="226" id="isPasted">in vivo</em> CAR T cells to the test

A boy in a black T-shirt sitting on a hospital bed next to his mother who is also wearing a black shirt.

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A boy in a checkered black, blue, and red shirt smiling and sitting on a sofa.

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A portrait of a woman wearing maroon shirt and a beaded necklace

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A portrait of a man wearing glasses in a suit.

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Scientists are advancing CAR T cell therapy to improve outcomes for children with acute lymphoblastic leukemia.

CAR T cells: The last line of defense against childhood leukemia

Cell Therapy

A kidney organoid showing blue, green, and red fluorescence.

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Animal and cell culture models have fallen short in kidney disease research. Kidney organoids may offer a better way forward.

Kidney disease research grows in a dish

A microscopy image of a human colon polyp is brightly lit up in green, red, and blue.

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New research suggests an unexpected role for T cells during a tumor&rsquo;s evolution from benign to malignant.

T cells may drive transition to cancer in colorectal tumors

Spatial Biology

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A mosquito sucks blood from a person’s arm.

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Strategies including parasite-based vaccines, mosquito-transmission blockers, and antibody drugs are promising new ways to target the disease. &nbsp;

Uncovering new approaches to prevent malaria

Sean Tucker wears a gray suit and dark blue button-down shirt and sits outside.

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A photo of a clear glass next to a white pill on a blue background.

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A variety of oral pills are shown on a white background with a syringe needle on top.

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Vaxart aims to revolutionize immunization by replacing injections with easy-to-take tablets.

New vaccine pills could replace intramuscular shots

Drug Formulation

Neurons representing brain function in diagnosing Parkinson’s disease

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New software and hardware tools that collect data while a person types can detect fine motor impairment &mdash; a possible sign of neurodegeneration.

Keyboard typing test could help diagnose Parkinson&rsquo;s disease early

Diagnostics

Scientific illustration of a cell releasing exosomes: small, spherical extracellular vesicles budding from and detaching off the cell’s plasma membrane into the surrounding space, shown as tiny capsule-like structures emerging from the cell surface.

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Unchained Labs

Learn how to distinguish true extracellular vesicles from similarly sized particles using affinity capture and immunofluorescence.

Lock-in unmatched EV characterization with Leprechaun

Webinars

Close-up of a scientist’s hands typing on a laptop next to a microscope in a laboratory setting.

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Revvity

Explore how a needs-driven approach to electronic laboratory notebook selection can improve data integrity, reproducibility, and scientific continuity.

A scientist&#39;s guide to electronic laboratory notebook selection

Articles

Scientist weighing a laboratory sample using a four-decimal analytical balance in a quality control setting.

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Sartorius

Learn the fundamental weighing principles and operational controls that support reliable sample preparation.

September 2025 Volume 21, Issue 3

September 2025

In this Issue