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September 2025

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Ryan Larson smiles wearing a blue, white, and brown checkered shirt with his arms crossed.

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A rendering of a CAR T cell on a dark blue background.

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Two ongoing Phase 1 trials will produce the first human data on these potentially revolutionary cancer drugs.

New clinical trial puts&nbsp;<em data-start="217" data-end="226" id="isPasted">in vivo</em> CAR T cells to the test

A boy in a black T-shirt sitting on a hospital bed next to his mother who is also wearing a black shirt.

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A boy in a checkered black, blue, and red shirt smiling and sitting on a sofa.

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A portrait of a woman wearing maroon shirt and a beaded necklace

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A portrait of a man wearing glasses in a suit.

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Scientists are advancing CAR T cell therapy to improve outcomes for children with acute lymphoblastic leukemia.

CAR T cells: The last line of defense against childhood leukemia

Cell Therapy

A kidney organoid showing blue, green, and red fluorescence.

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Animal and cell culture models have fallen short in kidney disease research. Kidney organoids may offer a better way forward.

Kidney disease research grows in a dish

A microscopy image of a human colon polyp is brightly lit up in green, red, and blue.

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New research suggests an unexpected role for T cells during a tumor&rsquo;s evolution from benign to malignant.

T cells may drive transition to cancer in colorectal tumors

Spatial Biology

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A mosquito sucks blood from a person’s arm.

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Strategies including parasite-based vaccines, mosquito-transmission blockers, and antibody drugs are promising new ways to target the disease. &nbsp;

Uncovering new approaches to prevent malaria

Sean Tucker wears a gray suit and dark blue button-down shirt and sits outside.

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A photo of a clear glass next to a white pill on a blue background.

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A variety of oral pills are shown on a white background with a syringe needle on top.

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Vaxart aims to revolutionize immunization by replacing injections with easy-to-take tablets.

New vaccine pills could replace intramuscular shots

Drug Formulation

Neurons representing brain function in diagnosing Parkinson’s disease

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New software and hardware tools that collect data while a person types can detect fine motor impairment &mdash; a possible sign of neurodegeneration.

Keyboard typing test could help diagnose Parkinson&rsquo;s disease early

Diagnostics

Portrait of Scott Weitze, Vice President of Research and Technical Standards at My Green Lab, beside text that reads “Tell us what you know: Bringing sustainability into scientific research,” with the My Green Lab logo.

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At My Green Lab® we are igniting a global shift toward environmentally responsible scientific research by helping labs to reduce their environmental impact.

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My Green Lab

Laboratories account for a surprising share of global emissions and plastic waste, making sustainability a priority for modern research.

Bringing sustainability into scientific research

Video

3D illustration of RNA molecules on a gradient blue background.

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Charles River 

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With diverse emerging modalities and innovative delivery strategies, RNA therapeutics are tackling complex diseases and unmet medical needs.

Exploring the RNA therapeutics universe&nbsp;

Infographics

A 3D rendering of red and yellow protein molecules floating in a fluid-like environment.

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Nuclera

Discover approaches that shorten the path from DNA constructs to purified, functional proteins.

September 2025 Volume 21, Issue 3

September 2025

In this Issue

Cell Therapy

New clinical trial puts in vivo CAR T cells to the test

CAR T cells: The last line of defense against childhood leukemia

Spatial Biology

Kidney disease research grows in a dish

T cells may drive transition to cancer in colorectal tumors

Drug Formulation

Uncovering new approaches to prevent malaria

New vaccine pills could replace intramuscular shots

Diagnostics

Keyboard typing test could help diagnose Parkinson’s disease early

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September 2025