September 2023- Volume 19, Issue 8

In this Issue

Editor's Focus

Top view of a breast tumor that might be treatable with the monoclonal antibody herceptin

Science Milestone: The rise of Herceptin

Science Milestone: The rise of Herceptin

Herceptin transformed breast cancer treatment and opened the door to targeted therapy. 
A hot spring showing concentric rings of different colors at Yellowstone National Park surrounded by forests.

Basic science: a key ingredient in innovation

Basic science: a key ingredient in innovation

From green fluorescent protein to polymerase chain reaction, many basic science discoveries fueled important advances in biomedicine.
An illustration of a person swallowing a pill as it descends through the esophagus, while a zoom-in view of the pill reveals a mixture of active ingredients and excipients

Explained: How does the body process oral medications?

Explained: How does the body process oral medications?

Upon ingesting drugs, a complex cascade of physiological events unfolds within the body. 

Metabolic Disease

A silhouette of a human torso shows the pancreas in red and a circular inset of a 3D illustration of insulin.

Biomaterials for better diabetes cell therapy

Biomaterials for better diabetes cell therapy

Aiming to restore insulin function in type 1 diabetes, Lonnie Shea develops scaffolds that support the growth and transplantation of pancreatic islet structures.

Hematology

A human heart dissolves into little square pieces against a grey background.

Targeting microbes to treat heart disease

Targeting microbes to treat heart disease

Inhibitors that target gut microbial enzymes are likely the key to treating a variety of cardiovascular diseases, some of which have no other cure.
A drawing of blue veins against a white background.

From the cancer research bench to the vascular disease bedside

From the cancer research bench to the vascular disease bedside

A search for a new cancer mouse model turned into the first ever treatment for a rare disease called venous malformations.
A photograph of Immunicom’s LW-02 cartridge.

Filtering out cancer’s invisibility cloak

Filtering out cancer’s invisibility cloak

By removing immunosuppressive factors from the blood, researchers hope to give the immune system a fighting chance against advanced tumors.

Cancer

A pole carrying a chemotherapy medicine bag stands in the foreground with a yellowish cloud representing mustard gas in the background.

Chemotherapy’s hidden origins

Chemotherapy’s hidden origins

From chemical warfare trenches, scientists glimpsed an opportunity to transform deadly mustard gas into a revolutionary cancer treatment.

Ophthamology

A side view of a human eye overlaid with a schematic of the internal eye structures.

Powering up cells to power down corneal disease

Powering up cells to power down corneal disease

Injecting healthy, exogenous mitochondria into the eye could combat mitochondrial dysfunction and cell death in Fuchs endothelial corneal dystrophy.
The surface of a retinal organoid showing many different cell types in different colors.

A vision of the future: Stem cells offer hope for retinal degeneration

A vision of the future: Stem cells offer hope for retinal degeneration

Cell therapies derived from stem cells could one day prevent vision loss or even restore sight in retinal degenerative disease.
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