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September 2023

A drawing of blue veins against a white background.

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Pau Castel leans against a bright orange wall in a hallway.

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A search for a new cancer mouse model turned into the first ever treatment for a rare disease called venous malformations.

From the cancer research bench to the vascular disease bedside

Phillip Owens stands next to a student in his lab, who is looking at a sample under the microscope.

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A human heart dissolves into little square pieces against a grey background.

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Members of the Owens and Tranter labs at the University of Cincinnati wear red and make hearts with their hands in celebration of “Go Red for Women Day.”

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Stanley Hazen wears a white lab coat and stands in a lightly colored room.

Inhibitors that target gut microbial enzymes are likely the key to treating a variety of cardiovascular diseases, some of which have no other cure.

Targeting microbes to treat heart disease

A photograph of Immunicom’s LW-02 cartridge.

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Amir Jafri holds up Immunicom’s LW-02 column, which binds blood circulating sTNFRs from solid tumors.

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A photograph of Termumo Blood and Cell Technologies 

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By removing immunosuppressive factors from the blood, researchers hope to give the immune system a fighting chance against advanced tumors.

Filtering out cancer&rsquo;s invisibility cloak

Hematology

A headshot of Lonnie Shea wearing a blue shirt and navy blazer.

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A microscopy image of a porous material (left). A circular cell culture dish packed with white cells (right). 

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A silhouette of a human torso shows the pancreas in red and a circular inset of a 3D illustration of insulin. 

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Aiming to restore insulin function in type 1 diabetes, Lonnie Shea develops scaffolds that support the growth and transplantation of pancreatic islet structures.

Biomaterials for better diabetes cell therapy

Metabolic Disease

A headshot of Ste?phanie Proulx wearing a red sweater. 

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A side view of a human eye overlaid with a schematic of the internal eye structures. 

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A headshot of Patrick Rochette wearing a blue button-up shirt. 

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A 3D rendering of blue and purple mitochondria against a black background. 

Injecting healthy, exogenous mitochondria into the eye could combat mitochondrial dysfunction and cell death in Fuchs endothelial corneal dystrophy.

Powering up cells to power down corneal disease

David Gamm wears a collared shirt and smiles at the camera.

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Kapil Bharti wears glasses and a lab coat while looking at a six well cell culture plate. 

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The surface of a retinal organoid showing many different cell types in different colors.

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Magdalene Seiler holds flowers and poses with several lab members outdoors.

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On the left is a cross section of an eye, on the right is a cross section of the cells in the retina, including the ganglion cells, amacrine cells, Müller glia, horizontal cells, rods, cones, and retinal pigment epithelium. 

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Cell therapies derived from stem cells could one day prevent vision loss or even restore sight in retinal degenerative disease.

A vision of the future: Stem cells offer hope for retinal degeneration

Ophthamology

An illustration of a person swallowing a pill as it descends through the esophagus, while a zoom-in view of the pill reveals a mixture of active ingredients and excipients 

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Upon ingesting drugs, a complex cascade of physiological events unfolds within the body.&nbsp;

Explained: How does the body process oral medications?

Top view of a breast tumor that might be treatable with the monoclonal antibody herceptin

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Herceptin transformed breast cancer treatment and opened the door to targeted therapy.&nbsp;

Science Milestone: The rise of Herceptin

A hot spring showing concentric rings of different colors at Yellowstone National Park surrounded by forests.

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From green fluorescent protein to polymerase chain reaction, many basic science discoveries fueled important advances in biomedicine.

Basic science: a key ingredient in innovation

Editor's Focus

A pole carrying a chemotherapy medicine bag stands in the foreground with a yellowish cloud representing mustard gas in the background.

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A historical photograph depicting the air attack on the Allied port in Bari, Italy on December 2, 1943, showing billowing smoke from burning ships and exploding ammunition. 

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Photographs of pharmacologists Alfred Gilman (left) and Louis Goodman (middle), and surgeon Gustaf Lindskog (right), who conducted the first human trial of nitrogen mustard to treat lymphosarcoma.

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Photographs of chemists Albert Niemann (left) and Viktor Meyer (right), pioneers of mustard gas synthesis. 

A photograph showing a Canadian soldier suffering burn injuries due to mustard gas exposure during World War I.

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Photograph of Cornelius Rhoads, who led research on using mustard gas for cancer treatment during and after World War II.

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From chemical warfare trenches, scientists glimpsed an opportunity to transform deadly mustard gas into a revolutionary cancer treatment.

Chemotherapy&rsquo;s hidden origins

Cancer

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Reliable fluid biomarkers strategies for clinical neuroscience research

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Bio-Techne

Explore how validated fluid biomarker assays advance clinical research for neurological diseases.

Webinars

Laboratorian with a white coat and blue gloves pipettes green liquid into a beaker with multicolored liquids in beakers and tubes in the blue-tinged, sterile laboratory background.  

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Shimadzu Corporation

New tools help researchers detect and manage harmful nitrosamine impurities in drugs such as monoclonal antibodies.

Discovering cutting-edge nitrosamine analysis in pharmaceuticals

Compendium

A starry night sky reflected over calm water, symbolizing the discovery of hidden patterns in complex systems.

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10x Genomics

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RareCyte

DeNovix

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Syncell

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Fortis Life Sciences

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Bruker Spatial Biology

Discover essential strategies and expert insights to navigate the expanding world of spatial biology.

September 2023 Volume 19, Issue 8