September 2022 Volume 18, Issue 9

September 2022

Volume 18, Issue 9 | September 2022

September 2022

In this Issue

Genetic Disease

An image shows the nuclear envelope connecting to the rough endoplasmic reticulum.

A drug that protects against Alzheimer’s disease may help with Wolfram Syndrome

Wolfram Syndrome is a rare disease that causes a myriad of challenges, including deafness, diabetes, and depression. New research suggests that an agonist used to treat neurodegenerative disorders may help alleviate some of the symptoms.
Colorful bands of DNA are shown against a black background, representing a DNA sequencing gel.

Missing mutations solve a genetic mystery

In a journey that spanned the genomes of more than 150,000 Icelanders, archival samples, and a fetus in utero, researchers not only identified genetic variants missing from the population, but also proved that these missing mutations cause three rare genetic diseases.

Editor's Focus

Red curtains on a stage stand partially open, revealing blurred out people standing behind them. Newsletter categories: infectious disease, microbiology, immunology

Science comedy gets to the heart of science communication

Using comedy to talk about technical topics makes science more accessible.
A 3D rendering of orange cancer cells, based on an electron micrograph, depicts spreading cancer filopodia and metastasis.

Explained: How does cancer spread?

Cancer cells acquire new skills to break free of their environmental constraints and  spread to new locations in the body.

Cancer

Colorful cancer ribbons arranged in a semi circle

Electric fields disrupt cancer cell division

A novel, non-invasive treatment using electrical currents exploits physiological properties of dividing cancer cells to prolong survival and augment current therapies.

Precision Medicine

A diverse group of people fill a SARS-CoV-2 shaped outline on a blue background.

A worldwide effort to bank patient DNA

Researchers around the world are on a mission to bank biological samples from millions of people. So far, these efforts have disclosed the effects of arsenic exposure on the genome, supported development of early cancer diagnostics, and even revealed the ideal timing for COVID-19 boosters.

Infectious Disease

Borrelia burgdorferi, the bacteria that cause Lyme disease, are shown surrounded by red blood cells against a light green background.

Lipoproteins hide Lyme bacteria from the immune system

Scientists identified two proteins that help Lyme bacteria evade detection by the human complement system, paving the way for new therapeutics and vaccine targets.
A field of tobacco plants in the sunlight may be used for plant-based vaccine production.

Understanding plant-based vaccines

Plants offer several unique advantages for accelerated vaccine production.
Grey monkeypox viruses with a dense filamentous outer layer and a black nuclear region.

What the Pox is Going On? 

Monkeypox virus is a close relative of the smallpox virus and the latest zoonotic pathogen to infect human beings.
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A black mosquito is shown on pink human skin against a blurred green backdrop.

Discovering deeper insights into malaria research

Malaria continues to drive urgent research worldwide, with new therapies and tools emerging to combat the parasite’s complex lifecycle and global burden.
Three burgundy round and linear conformations of oligonucleotides are shown against a black background.

Accelerating RNA therapeutic testing with liver microphysiological platforms

Researchers can now study oligonucleotide delivery and efficacy in a system that models a real human liver.
A 3D-rendered illustration of a eukaryotic cell highlighting organelles such as the nucleus, endoplasmic reticulum, mitochondria, and cytoskeletal structures in pink and purple tones.

Shining light on the subcellular proteome

Discover how innovative proteomics tools help researchers peer into once inaccessible organelles, allowing for new targets for drug discovery and development.
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