September 2022- Volume 18, Issue 9

In this Issue

Editor's Focus

Red curtains on a stage stand partially open, revealing blurred out people standing behind them. Newsletter categories: infectious disease, microbiology, immunology
A 3D rendering of orange cancer cells, based on an electron micrograph, depicts spreading cancer filopodia and metastasis.

Explained: How does cancer spread?

Explained: How does cancer spread?

Cancer cells acquire new skills to break free of their environmental constraints and  spread to new locations in the body.

Genetic Disease

Colorful bands of DNA are shown against a black background, representing a DNA sequencing gel.

Missing mutations solve a genetic mystery

Missing mutations solve a genetic mystery

In a journey that spanned the genomes of more than 150,000 Icelanders, archival samples, and a fetus in utero, researchers not only identified genetic variants missing from the population, but also proved that these missing mutations cause three rare genetic diseases.
An image shows the nuclear envelope connecting to the rough endoplasmic reticulum.

A drug that protects against Alzheimer’s disease may help with Wolfram Syndrome

A drug that protects against Alzheimer’s disease may help with Wolfram Syndrome

Wolfram Syndrome is a rare disease that causes a myriad of challenges, including deafness, diabetes, and depression. New research suggests that an agonist used to treat neurodegenerative disorders may help alleviate some of the symptoms.

Cancer

Colorful cancer ribbons arranged in a semi circle

Electric fields disrupt cancer cell division

Electric fields disrupt cancer cell division

A novel, non-invasive treatment using electrical currents exploits physiological properties of dividing cancer cells to prolong survival and augment current therapies.

Precision Medicine

A diverse group of people fill a SARS-CoV-2 shaped outline on a blue background.

A worldwide effort to bank patient DNA

A worldwide effort to bank patient DNA

Researchers around the world are on a mission to bank biological samples from millions of people. So far, these efforts have disclosed the effects of arsenic exposure on the genome, supported development of early cancer diagnostics, and even revealed the ideal timing for COVID-19 boosters.

Infectious Disease

Borrelia burgdorferi, the bacteria that cause Lyme disease, are shown surrounded by red blood cells against a light green background.

Lipoproteins hide Lyme bacteria from the immune system

Lipoproteins hide Lyme bacteria from the immune system

Scientists identified two proteins that help Lyme bacteria evade detection by the human complement system, paving the way for new therapeutics and vaccine targets.
Grey monkeypox viruses with a dense filamentous outer layer and a black nuclear region.

What the Pox is Going On? 

What the Pox is Going On? 

Monkeypox virus is a close relative of the smallpox virus and the latest zoonotic pathogen to infect human beings.
A field of tobacco plants in the sunlight may be used for plant-based vaccine production.

Understanding plant-based vaccines

Understanding plant-based vaccines

Plants offer several unique advantages for accelerated vaccine production.
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