September 2019- Volume 15, Issue 9

In this Issue

Business & Government Policy

CRISPR ownership fight gets complicated

CRISPR ownership fight gets complicated

Kevin Noonan discusses recent developments around researchers vying for ownership of aspects of the gene-editing technology directed to eukaryotic cells

Illumina expands genomics accelerator to Cambridge

Illumina expands genomics accelerator to Cambridge

Company partners with leading European venture capital firms to build genomics startups

New DNA/RNA therapeutics company goes public

New DNA/RNA therapeutics company goes public

NeuBase Therapeutics closes merger transaction with Ohr Pharmaceutical

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

Feature

Guest Commentary: From Prop. 71 to CAR-T and beyond: Enabling another 15 years of patient-centric innovation

Guest Commentary: From Prop. 71 to CAR-T and beyond: Enabling another 15 years of patient-centric innovation

In 2004, California voters passed the California Stem Cell Research and Cures Act to create a foundation for regenerative medicine in the United States at a time when federal funding support declined. No one could have predicted the myriad scientific and medical innovations that have arisen since. This commentary takes a look back at what has happened in those 15 years, as well as to the future of the field

Neuroscience 2019 Show Preview: The newest in the neurological

Neuroscience 2019 Show Preview: The newest in the neurological

From neurodegenerative disorders to neurogenesis, Neuroscience 2019 showcases cutting-edge research

Commentary

Out of order: Check your ego

Out of order: Check your ego

Science can continue to humble even the best among us, even when something interesting and practical is discovered

Guest Commentary: How humanized machine learning is giving the life-sciences industry a shot in the arm

Guest Commentary: How humanized machine learning is giving the life-sciences industry a shot in the arm

Some thoughts on how the life-sciences sector as a whole can boost productivity, reduce the time to market and unlock the full value of data with AI and machine learning

Contract Services

The fruit of a long relationship

The fruit of a long relationship

Deal takes combined company one step closer toward expanding geographic footprint

Furthering formulations

Furthering formulations

MedPharm expands relationship with Novan on formulation science

European CMOs invest heavily in containment

European CMOs invest heavily in containment

Almost 70 percent of CMO high-containment facilities in Europe found in six nations

Clinical Trials

Taking aim at AML

Taking aim at AML

Chimerix secures license to AML candidate with unique mechanism of action

Genes may regulate immunotherapy

Genes may regulate immunotherapy

Ziopharm’s Controlled interleukin 12 seems to improve T cell recruitment with less toxicity than past IL-12 therapies

Heart healthy

Heart healthy

Combo drug manages cholesterol and CRP in study

Going up against Prader-Willi

Going up against Prader-Willi

Soleno provides update on ongoing DESTINY PWS Phase 3 trial

Weaving a Tapestri in oncology

Weaving a Tapestri in oncology

New alliance will use Mission Bio’s Tapestri Platform to investigate Onconova’s rigosertib

Diagnostics

TARDIS: A ‘game-changer’

TARDIS: A ‘game-changer’

Mayo and TGen join hands with Cambridge on test to improve, personalize breast cancer treatment

A new Alzheimer’s application for LymPro

A new Alzheimer’s application for LymPro

Todos Medical announces positive Alzheimer’s biomarker clinical data from LymPro Test

Revenue on the horizon

Revenue on the horizon

CytoDyn inks licensing agreement for PA-14 and PRO 140 for diagnostic use

Targeted RNA NGS for breast cancer

Targeted RNA NGS for breast cancer

Agendia announces publication of study validating use of MammaPrint and BluePrint

Research & Development

Three dimensions of the human genome

Three dimensions of the human genome

New algorithm could enable a closer, more accurate way to model genes

My stars and gar-ters

My stars and gar-ters

Genes responsible for regenerating fins in garfish are found to also be present in humans

Deepening diversity

Deepening diversity

NIH-funded research highlights the need for diversity in study populations

American BriVision teams up with BioLite Japan

American BriVision teams up with BioLite Japan

Collaboration combines early-stage discovery capabilities with clinical trial expertise

TARA’s heart-on-a-chip sees success

TARA’s heart-on-a-chip sees success

Heart-on-a-chip system mimics drug response seen in humans

Virtual R&D vs. cancer

Virtual R&D vs. cancer

Boehringer Ingelheim and MD Anderson form unique R&D center to rapidly advance new cancer treatments

Discovery

From the uterus to the spine

From the uterus to the spine

Amniotic fluid stem cells show promise in models of spina bifida

A break in the case

A break in the case

Two enzymes indicted in inflammation and tumor growth in non-small cell lung carcinomas

Insight for research

Insight for research

Company launches first automation-compatible 3D human liver disease platform for NASH drug discovery

Proteins and cancer

Proteins and cancer

Eisai enters into collaboration research agreement with University of Dundee

New hope for sepsis treatment

New hope for sepsis treatment

UCSD scientists explore the role of PHLPP1 and how its absence can boost survival in mice

Preclinical

Cancer model metadata

Cancer model metadata

Repositive makes cancer models publicly browsable

New breakthroughs for viral HIV vaccine

New breakthroughs for viral HIV vaccine

HIV-like ‘death star’ strain defeated with gene therapy-inspired approach

High hopes for HERA

High hopes for HERA

HERA-GITRL shows potent, specific targeting in cancer animal models

Adjusting alcohol-seeking behavior

Adjusting alcohol-seeking behavior

Aptinyx presents data demonstrating robust activity of NYX-783 in multiple models

Special Reports

Stem Cells Special Report: Hope over hype

Stem Cells Special Report: Hope over hype

Unveiling the true promise of stem cell therapy, not the empty promises

Editor's Focus

Editor’s Focus: Artificial and essential, but still just a tool

Editor’s Focus: Artificial and essential, but still just a tool

Artificial intelligence is an increasingly important component of the life sciences and pharma/biotech, but let's not lose sight of the fact that it should help, not be designed to lead
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