September 2016- Volume 12, Issue 9

September 2016

In this Issue

Contract Services

If you build it, they will come

If you build it, they will come

Vetter to invest $320 million in manufacturing plant

Promising opportunities

Promising opportunities

Private equity fund targets life-sciences and healthcare services, starting with CRO

Recent recognition

Recent recognition

A collection of some CROs lauded within the industry

Research & Development

New nanoscale tech could revolutionize microscopes and study of disease

New nanoscale tech could revolutionize microscopes and study of disease

University of Missouri researchers recently published a study outlining a new, relatively inexpensive imaging platform that enables single-molecule imaging

Biological circuit design gets complex

Biological circuit design gets complex

New approach in cell programming enables scientists to track cell histories

JTX-2011, the driving force

JTX-2011, the driving force

Jounce join hands with Celgene to develop next-generation immuno-oncology therapies

HCV vaccine potential?

HCV vaccine potential?

Stem cell research reveals umbilical cord stem cells can block HCV infection

BC Platforms to partner with Codigo46

BC Platforms to partner with Codigo46

Deal will support the creation of the largest biobank in Latin America

Keeping genetics straight in cancer cells

Keeping genetics straight in cancer cells

Agilent CGH platform helps assure quality of cancer cell lines

Diagnostics

TTP unveils new instrument development service

TTP unveils new instrument development service

Service aimed at moving assays to market-ready products for rapidly delivering ‘sample to answer’

Better outcomes through liquid biopsy

Better outcomes through liquid biopsy

Genomic Health and Epic collaborate to deliver prognostic biomarker for metastatic prostate cancer

Lab-on-a-chip advancement

Lab-on-a-chip advancement

IBM unveils new technology that allows for the sorting of smaller particles than ever

Tox prognostication

Tox prognostication

Crowdsourced scientific challenge supports predictive power of computational biology for toxicology
Boosting breast cancer diagnostics

Boosting breast cancer diagnostics

Boosting breast cancer diagnostics

Study teams up protein biomarkers to increase accuracy of early breast cancer detection

Clinical Trials

Skin disease solution

Skin disease solution

Abeona engages in partnership for EB gene therapy treatments

Wearable tech for trials

Wearable tech for trials

Medidata, Memorial Sloan Kettering Cancer Center to use mHealth wearable activity trackers in clinical trials

On to Phase 3 for PLX-PAD

On to Phase 3 for PLX-PAD

Pluristem will be using a recent $8M grant for a pivotal trial in critical limb ischemia

An eye on white blood cells in black patients

An eye on white blood cells in black patients

Georgetown Lombardi begins first clinical trial to test palbociclib on African-American patients

Endpoint met for rare lung disease agent

Endpoint met for rare lung disease agent

Phase 2 results promising for Kamada’s inhaled alpha-1 antitrypsin for treatment of AATD

Preclinical

FibroStatin’s T12 ready to deliver TKO?

FibroStatin’s T12 ready to deliver TKO?

Lead candidate proves effective in fight vs. drug-resistant invasive cancer, organ fibrosis

ArQule presents preclinical data for ARQ 531

ArQule presents preclinical data for ARQ 531

Data supports further preclinical and clinical research in BTK-sensitive and ibrutinib-resistant malignancies

Transformative transaction

Transformative transaction

Chronos acquires preclinical programs from Shire to expand pipeline

Getting into the liver with CRISPR

Getting into the liver with CRISPR

Data from Intellia show continued progress in in-vivo gene editing with systemic lipid nanoparticle delivery

Anti-malaria drug could make tumors easier to treat

Anti-malaria drug could make tumors easier to treat

A recent study looked at the effect of atovaquone on tumors with low oxygen levels in mice

MR Solutions offers choice of two preclinical cryogen- free MRI scanner ranges

MR Solutions offers choice of two preclinical cryogen- free MRI scanner ranges

MR Solutions is now offering a choice of two cryogen-free preclinical scanner ranges: the Flexiscan and Powerscan

Business & Government Policy

Going after growth

Going after growth

Agile aiming to expand contraceptive pipeline with new regimen

Mylan draws heat around EpiPen cost

Mylan draws heat around EpiPen cost

Controversy is bringing about a call for potential regulatory changes

Preventing disparities in gene-based therapeutics and diagnostics

Preventing disparities in gene-based therapeutics and diagnostics

For all their promise, genetically based therapeutics and diagnostics still fall short of being representative of—and applicable to—the population as a whole

A first for Fast Track designation

A first for Fast Track designation

Caladrius’ CLBS03 is first experimental therapeutic for type 1 diabetes to get such designation

Q&A

Q&A: Checking in with the new MilliporeSigma

Q&A: Checking in with the new MilliporeSigma

DDNews discusses with Klaus-Reinhard Bischoff how things are going since Merck KGaA acquired Sigma-Aldrich in 2015 and combined it with EMD Millipore

Discovery

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

Cross-country collaboration

Cross-country collaboration

Regeneron links up with Adicet for next-gen immune cell therapeutics

Crowdsourcing lung biology

Crowdsourcing lung biology

A group effort on lung disease leads to new biological network model

A new target for NASH treatment

A new target for NASH treatment

BioLineRx inks deal with Hadasit for immune system approach to treating liver disease

Seres models the gut

Seres models the gut

Company teams with Emulate Inc. on microbiome therapeutics for IBD and other serious conditions

Feature

Show Preview: CPhI Worldwide--What to expect from CPhI Worldwide this fall

Show Preview: CPhI Worldwide--What to expect from CPhI Worldwide this fall

The pharma community will gather to showcase services, latest research and debate key industry issues in Barcelona, Spain

Show Preview: ASHG 2016--Digging into the genome in Canada

Show Preview: ASHG 2016--Digging into the genome in Canada

The American Society of Human Genetics brings its annual meeting to Vancouver, with plenty new to offer, as well as the familiar and traditional

Editor's Focus

Knowledge gaps and mistakes, and how both can lead to better things

Knowledge gaps and mistakes, and how both can lead to better things

Let's try to cut down on the hyperbole, learn better from our mistakes and accidents and find where we can cut down on unnecessary gaps in our knowledge

Commentary

Out of order: I am not an animal

Out of order: I am not an animal

Companies may need to share preclinical data with investors, the trade press and the like, but perhaps sharing a lot less of that early-stage data with the general public would be a good idea

Guest commentary: Direct-to-consumer genetic testing--Helpful or harmful?

Guest commentary: Direct-to-consumer genetic testing--Helpful or harmful?

Personalized or precision medicine is the future for many complex diseases, but simply giving a patient knowledge of their genetic predisposition to a disease is not enough
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