September 2016 Volume 12, Issue 9

Volume 12, Issue 9 | September 2016

September 2016

In this Issue

Q&A

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Q&A: Checking in with the new MilliporeSigma

DDNews discusses with Klaus-Reinhard Bischoff how things are going since Merck KGaA acquired Sigma-Aldrich in 2015 and combined it with EMD Millipore

Feature

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Show Preview: CPhI Worldwide--What to expect from CPhI Worldwide this fall

The pharma community will gather to showcase services, latest research and debate key industry issues in Barcelona, Spain
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Show Preview: ASHG 2016--Digging into the genome in Canada

The American Society of Human Genetics brings its annual meeting to Vancouver, with plenty new to offer, as well as the familiar and traditional
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Special Focus: Recruiting the body in the war against cancer

DDNews checks in on the growing and promising activity around immuno-oncology

Editor's Focus

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Knowledge gaps and mistakes, and how both can lead to better things

Let's try to cut down on the hyperbole, learn better from our mistakes and accidents and find where we can cut down on unnecessary gaps in our knowledge

Commentary

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Out of order: I am not an animal

Companies may need to share preclinical data with investors, the trade press and the like, but perhaps sharing a lot less of that early-stage data with the general public would be a good idea
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Guest commentary: Direct-to-consumer genetic testing--Helpful or harmful?

Personalized or precision medicine is the future for many complex diseases, but simply giving a patient knowledge of their genetic predisposition to a disease is not enough

Research & Development

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Keeping genetics straight in cancer cells

Agilent CGH platform helps assure quality of cancer cell lines
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Biological circuit design gets complex

New approach in cell programming enables scientists to track cell histories
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JTX-2011, the driving force

Jounce join hands with Celgene to develop next-generation immuno-oncology therapies
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HCV vaccine potential?

Stem cell research reveals umbilical cord stem cells can block HCV infection
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New nanoscale tech could revolutionize microscopes and study of disease

University of Missouri researchers recently published a study outlining a new, relatively inexpensive imaging platform that enables single-molecule imaging
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BC Platforms to partner with Codigo46

Deal will support the creation of the largest biobank in Latin America

Diagnostics

Boosting breast cancer diagnostics

Study teams up protein biomarkers to increase accuracy of early breast cancer detection
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TTP unveils new instrument development service

Service aimed at moving assays to market-ready products for rapidly delivering ‘sample to answer’
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Better outcomes through liquid biopsy

Genomic Health and Epic collaborate to deliver prognostic biomarker for metastatic prostate cancer
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Lab-on-a-chip advancement

IBM unveils new technology that allows for the sorting of smaller particles than ever
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Tox prognostication

Crowdsourced scientific challenge supports predictive power of computational biology for toxicology

Clinical Trials

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Endpoint met for rare lung disease agent

Phase 2 results promising for Kamada’s inhaled alpha-1 antitrypsin for treatment of AATD
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Skin disease solution

Abeona engages in partnership for EB gene therapy treatments
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Wearable tech for trials

Medidata, Memorial Sloan Kettering Cancer Center to use mHealth wearable activity trackers in clinical trials
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On to Phase 3 for PLX-PAD

Pluristem will be using a recent $8M grant for a pivotal trial in critical limb ischemia
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An eye on white blood cells in black patients

Georgetown Lombardi begins first clinical trial to test palbociclib on African-American patients

Discovery

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Cross-country collaboration

Regeneron links up with Adicet for next-gen immune cell therapeutics
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Crowdsourcing lung biology

A group effort on lung disease leads to new biological network model
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A new target for NASH treatment

BioLineRx inks deal with Hadasit for immune system approach to treating liver disease
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Seres models the gut

Company teams with Emulate Inc. on microbiome therapeutics for IBD and other serious conditions
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On the cutting edge

A roundup of instrumentation, software and other tools and technology news

Business & Government Policy

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A first for Fast Track designation

Caladrius’ CLBS03 is first experimental therapeutic for type 1 diabetes to get such designation
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Going after growth

Agile aiming to expand contraceptive pipeline with new regimen
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Mylan draws heat around EpiPen cost

Controversy is bringing about a call for potential regulatory changes
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Preventing disparities in gene-based therapeutics and diagnostics

For all their promise, genetically based therapeutics and diagnostics still fall short of being representative of—and applicable to—the population as a whole

Preclinical

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FibroStatin’s T12 ready to deliver TKO?

Lead candidate proves effective in fight vs. drug-resistant invasive cancer, organ fibrosis
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ArQule presents preclinical data for ARQ 531

Data supports further preclinical and clinical research in BTK-sensitive and ibrutinib-resistant malignancies
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Transformative transaction

Chronos acquires preclinical programs from Shire to expand pipeline
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Getting into the liver with CRISPR

Data from Intellia show continued progress in in-vivo gene editing with systemic lipid nanoparticle delivery
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Anti-malaria drug could make tumors easier to treat

A recent study looked at the effect of atovaquone on tumors with low oxygen levels in mice
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MR Solutions offers choice of two preclinical cryogen- free MRI scanner ranges

MR Solutions is now offering a choice of two cryogen-free preclinical scanner ranges: the Flexiscan and Powerscan

Contract Services

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Promising opportunities

Private equity fund targets life-sciences and healthcare services, starting with CRO
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If you build it, they will come

Vetter to invest $320 million in manufacturing plant
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Recent recognition

A collection of some CROs lauded within the industry
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Driving gene therapy with nonviral vectors 

Learn why nonviral vectors are on the rise in gene therapy development.
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Milestone: Leapfrogging to quantitative, high throughput protein detection and analysis

Researchers continuously push the boundaries of what’s possible with protein analysis tools.
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Advancing immuno-oncology research with cellular assays

Explore critical insights into immunogenicity and immunotoxicity assays for cancer therapies.
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