October 2023- Volume 19, Issue 9

In this Issue

Editor's Focus

A drawing of a purple hand with 4 pills in the open palm. One pill contains a syringe. In the background are DNA, antibodies, a cross-sectional diagram of a robotic capsule, and mathematic equations.

Robotic pills deliver gastrointestinal injections

Robotic pills deliver gastrointestinal injections

Researchers developed ingestible capsules that inject drugs into the stomach and small intestine, providing a novel oral delivery method for biologics.

Editors Insight

A side view of a man wearing a button-up shirt, dress pants, and loafers sitting in a box with his hand against the top of the box in a dark room.

Scientists, don’t stick to the status quo

Scientists, don’t stick to the status quo

We should expand our definition of what it means to be a scientist to include all of the important roles that stem from this identity.  

Human Genetics

An illustration of a blue double helix surrounded by red spiky viruses.

Human genetics influence susceptibility to infection

Human genetics influence susceptibility to infection

Scientists identified specific genes that confer protection or vulnerability to various infections, pointing the way to new treatments.
A characteristically doughnut-shaped red blood cell is in focus in the foreground, other red blood cells are out of focus in the background.

New weapons in the fight against sickle cell disease

New weapons in the fight against sickle cell disease

For decades, treatment options for sickle cell disease have been extremely limited. Soon, gene therapies and a host of pharmaceuticals could alleviate the immense burden of this disease.

Drug Formulation

A drawing of a scientist in a lab coat with a magnifying glass looks into the stomach.

No more daily pills: A new star in long-acting drug delivery

No more daily pills: A new star in long-acting drug delivery

With a star-shaped drug delivery platform that can stay in the stomach for a week or more, researchers hope to improve medication compliance and overall health.
An illustration of genetic engineering with CRISPR/Cas9, a powerful tool for gene editing that may cause off-target effects if used without molecular safety switches.

Safety buttons for CRISPR/Cas9

Safety buttons for CRISPR/Cas9

New technologies keep CRISPR/Cas9 in check and minimize off-target risks.

Microbiology

Mycobacterium tuberculosis glow fluorescent yellow in a microscope image of a patient sample.

Lighting up tuberculosis with point-of-care diagnostics

Lighting up tuberculosis with point-of-care diagnostics

Mireille Kamariza develops new chemistry-driven diagnostics for tuberculosis that can reduce the time to treatment from weeks to minutes.
A microscope image shows HIV in red budding from an immune cell in blue.

An mRNA twist to the HIV vaccine problem

An mRNA twist to the HIV vaccine problem

For decades, researchers have tried to craft a successful vaccine for HIV. mRNA vaccines may offer the answer.

Bioanalytics

A group of black and white striped adult zebrafish swim in dark water.

Fishing for safer nanomedicine

Fishing for safer nanomedicine

To pinpoint nanomaterials that show toxic effects in biological systems, researchers rely on the petite but powerful zebrafish.
Two microscopy images show a green cell resting on a pink horizontal membrane and breaking through the membrane.

A squirmy system for studying cancer’s spread

A squirmy system for studying cancer’s spread

Researchers use fluorescence-based imaging to visualize a cellular invasion event in worms, revealing candidates for gene knockdown strategies to block metastasis.
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