October 2021 Volume 17, Issue 10

October 2021 Issue, Drug Discovery News

Volume 17, Issue 10 | October 2021

October 2021

In this Issue

Microbiology

EHEC grown on an agar plate.

E. coli may hold the key to manufacturing hard-to-make drugs

Scientists combined engineered E. coli with artificial intelligence to produce effective, high-quality protein and antibody-based drugs at a large scale.
child in orange shirt is looking out a window

Targeting gut bacteria to treat autism

Scientists leverage the gut microbiome-brain connection to develop new treatments for autism spectrum disorders.
Veterinarian with syringe ready to give vaccine shot to pigs at cattle farm

Antimicrobial resistance: The silent pandemic

Scientists continue to ring alarm bells about the risks associated with the continued misuse of antimicrobials and advocate for innovative treatments, improved surveillance, and greater public health education.

Rare Diseases

ACOX1-driven neurodegeneration is one of the diseases that Bellen’s team has modeled in flies to find drug treatments. In a fly without ACOX1, the immune system attacks the fly’s own tissue.

Genetic studies of rare undiagnosed diseases take flight with model organisms

Researchers use fruit flies to figure out how genetic mutations disrupt biology and how drugs might reverse these effects.
Disabled boy in wheelchair holding mother's hand on path

CRISPR-based muscular dystrophy therapy

An engineer turned biology researcher co-founded a bio-pharma start-up with the goal of using CRISPR to reverse the mutation causing the degenerative muscle disorder Duchenne muscular dystrophy.
A drawing of a person with a healthy arm muscle is shown on the left. An arrow points to a drawing of a person with a dystrophied muscle in a circle on the right.

Infographic: CRISPR editing for treating Duchenne muscular dystrophy

Researchers are using CRISPR gene editing to restore function of the mutant protein that causes Duchenne muscular dystrophy, a genetic disease that causes muscle degeneration.

Cell Biology

Big Data futuristic background

Decoding cell behavior and disease with AI and single-cell transcriptomics

Machine learning paired with single-cell analysis helps scientists identify pathways that cause disease and potential therapeutics.
A DNA molecule is shown in blue with one edited piece of a strand in red.

Harnessing cells' own RNA editing tools for new therapeutics 

By redirecting cells’ endogenous RNA editing machinery, scientists can correct disease-causing mutations, bringing a new kind of gene therapy to the clinic.
Grim Reaper

Special report: Live and let die

Researchers redefine cell death in disease and drug discovery.

Editor's Insight

Black swan

The black swan

How can scientists bridge the communication gap between themselves and the public?
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Close-up illustration of clustered, irregularly shaped 3D cell structures resembling organoids, displayed in a blue-toned background.
Machine learning-powered image analysis makes it possible to automatically and reliably quantify complex 3D cell structures.
Illustration of a glowing human brain with interconnected neural networks and bright data points, set against a dark, digital background.
Take a closer look at modern techniques that reveal when, where, and how neurons communicate in real time.
Gloved hand holding a petri dish containing red liquid culture medium against a light blue background.
As global regulations shift toward animal-free testing, how can researchers develop more biologically relevant in vitro models to advance drug discovery?
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