October 2020- Volume 16, Issue 9

In this Issue

Discovery

Lodo Therapeutics acquires Conifer Point

Lodo Therapeutics acquires Conifer Point

Lodo expands AI/ML capabilities and gains exclusive rights to suite of cheminformatics technologies
RNA to repair a heart

RNA to repair a heart

RNA to repair a heart

Scripps team identifies molecule that can bind to RNA to increase VEGF-A production

Jnana and Roche investigate SLCs

Jnana and Roche investigate SLCs

Innovative approach for modulating cellular metabolism could treat a variety of diseases

Understanding lupus one cell at a time

Understanding lupus one cell at a time

JAX team finds distinctive interferon gene expression signature across wide variety of blood cells

Preclinical

Video: Riding the Wave

Video: Riding the Wave

Video: Riding the Wave

Wave Life Sciences releases preclinical data for ADAR editing and C9orf72 program

Down-regulating PTB

Down-regulating PTB

One-time Parkinson’s treatment generates new neurons

Second-gen COVID vaccine in development

Second-gen COVID vaccine in development

OSE Immunotherapeutics leverages cancer vaccine to develop CoVepiT

Diagnostics

Advancing a SARS-CoV-2 antigen test

Advancing a SARS-CoV-2 antigen test

Avacta and LSTM collaborate to clinically validate saliva-based rapid coronavirus test

Wellcome Sanger updates DECIPHER

Wellcome Sanger updates DECIPHER

Institute also working on genetic prediction of blood diseases and ramping up COVID-19 research

Discovering pancreatic cancer earlier

Discovering pancreatic cancer earlier

Collaborative studies at University of Missouri show promise

A 10-minute test for COVID

A 10-minute test for COVID

Todos announces positive data for new point-of-care saliva-based test

Business & Government Policy

J&J seeks immune momentum with Momenta

J&J seeks immune momentum with Momenta

Pharma giant acquires Momenta for $6.5B, setting sights on autoantibody-driven disease market

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

Q&A: Tackling developmental disorders through the ERK pathway

Q&A: Tackling developmental disorders through the ERK pathway

DDN spoke with Dr. Michael Snape, chief scientific officer of AMO Pharma, to discuss drugs that target the ERK signaling cascade, and how these drugs might be able to treat a range of developmental disorders

Commentary

Out of Order: Sausage-making

Out of Order: Sausage-making

Science is knowing you never have a complete answer and challenging any answer that arises. To the general public, however, this uncertainty rankles at a minimum and terrifies in its extreme.

Guest Commentary: RNA-seq in preclinical research and drug discovery--digging deep for insights

Guest Commentary: RNA-seq in preclinical research and drug discovery--digging deep for insights

RNA-seq offers a comprehensive method for studying differential gene expression and changing levels of noncoding RNAs at both the single-cell and bulk sequencing levels, thus offering a powerful arsenal of investigative tools for understanding the molecular basis of disease and for the discovery and testing of new treatment options
Editor’s Focus: Nearing year’s end and looking forward

Editor’s Focus: Nearing year’s end and looking forward

Editor’s Focus: Nearing year’s end and looking forward

DDN is evolving in all its forms, from print to online, and we look forward to unveiling it all soon

Special Reports

Special Report on Metabolic Disease: Intercepting diabetes

Special Report on Metabolic Disease: Intercepting diabetes

Researchers are increasingly targeting autoimmunity rather than hyperglycemia as they search for better ways to treat type 1 diabetes

Clinical Trials

One and done for HIV?

One and done for HIV?

AGT begins Phase 1 clinical trial on potential cure for HIV/AIDS

Adjunctive achievement

Adjunctive achievement

OCD drug candidate posts good Phase 2/3 study results

Research & Development

Better health with humanin?

Better health with humanin?

USC-led study says humanin could lower risk for Alzheimer’s

Utrecht and Bruker team up on mass spec methods

Utrecht and Bruker team up on mass spec methods

Crosslinking mass spectrometry can now use PhoX Crosslinker and TIMS/PASEF methods

Going after glioblastoma

Going after glioblastoma

Purdue team looks to harness natural killer cells to fight cancer

Contract Services

A bottleneck to hold up ATMP progress?

A bottleneck to hold up ATMP progress?

GlobalData says few CMOs are equipped to manufacture cell and gene therapies

Maravai expands again to meet mRNA therapy and vaccine demand

Maravai expands again to meet mRNA therapy and vaccine demand

Company expands TriLink BioTechnologies CleanCap capacity and adds new plasmid DNA manufacturing
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