October 2016- Volume 12, Issue 10

October 2016

In this Issue

Business & Government Policy

French connection

French connection

Advanced Analytical establishes office in Genopole, France

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

For your approval

For your approval

A collection of recent regulatory approvals and other actions globally

Determining cell death

Determining cell death

NIH-university collaboration advances potential Zika virus treatments

Patent Docs: The Trans-Pacific Partnership--What it may mean for the pharmaceutical industry

Patent Docs: The Trans-Pacific Partnership--What it may mean for the pharmaceutical industry

While the treaty’s principal provisions include lower tariffs and dispute resolution mechanisms, there are several sections related to patent law relevant to the U.S. pharmaceutical industry, and Kevin Noonan explains

Diagnostics

Breaking new ground with infectious disease

Breaking new ground with infectious disease

JAX-bioMérieux diagnostics partnership aims at better pathogen identification and countering antimicrobial resistance

A new ANGLE on biopsies

A new ANGLE on biopsies

MD Anderson Cancer Center research validates efficacy of Parsortix liquid biopsy system

A federal challenge

A federal challenge

NIH competition seeks diagnostic tools to combat antimicrobial resistance

More precision for personalized medicine

More precision for personalized medicine

Mount Sinai center aims to use computer vision technology for diagnosis and treatment

Contract Services

Calithera selects ProTrials for early-phase trial support

Calithera selects ProTrials for early-phase trial support

Agreement provides clinical development services for Calithera’s CB-839 oncology therapeutic

Crown Bioscience boosts oncology offerings

Crown Bioscience boosts oncology offerings

Company expands site and services at San Diego Center of Excellence for Oncology

Charles River acquires Agilux Laboratories

Charles River acquires Agilux Laboratories

M&A deal enhances Charles River’s early-stage capabilities in bioanalytical services

Cinven expands clinical services footprint

Cinven expands clinical services footprint

Bioclinica acquisition deal marks the first investment with the Sixth Cinven Fund

Discovery

New understanding of cocaine addiction

New understanding of cocaine addiction

Recent TSRI study findings suggest pharmacological remedies are possible

Warp speed ahead

Warp speed ahead

Company gets SMART Platform patent for identifying new therapeutic agents naturally

The promise of peroxiredoxin

The promise of peroxiredoxin

A protein that clears hydrogen peroxide from cells could offer new options for antibiotics

Stanford and twoXAR team up against liver cancer

Stanford and twoXAR team up against liver cancer

Researchers to validate computationally derived drug candidates targeting hepatocellular carcinoma

Research & Development

Junk DNA and genomic stability

Junk DNA and genomic stability

Duke researchers discover connection between junk DNA variations and increased risk of cancer or other diseases

Four months, four agreements

Four months, four agreements

Selexis inks cell license agreement with Pieris for immuno-oncology bispecific drug candidate

Of eggs and enzymes

Of eggs and enzymes

‘Egg unboiling’ technology could change the way enzymes are used in research

Getting to the heart of HCM

Getting to the heart of HCM

Stem-cell model of heart condition reveals how the fibrosis is perpetuated

InSphero launches 3D mitochondrial toxicity testing service

InSphero launches 3D mitochondrial toxicity testing service

InSight Mitochondrial Toxicity Testing provides for the identification of mitochondrial liabilities during drug development and safety testing

First proposal of strategies for validating antibody specificity

First proposal of strategies for validating antibody specificity

The International Working Group on Antibody Validation announced recently the publication of initial strategies developed to address a critical unmet need for antibody specificity, functionality and reproducibility

Delving into drug delivery

Delving into drug delivery

F-star and Denali to develop multispecific antibody platform for crossing blood-brain barrier

Preclinical

Abeta, pGlu-Abeta and Alzheimer’s

Abeta, pGlu-Abeta and Alzheimer’s

German biopharmaceutical Probiodrug’s preclinical trial takes giant step toward treating Alzheimer’s disease

DRGNET aims for less reliance on animals in pain research

DRGNET aims for less reliance on animals in pain research

Metrion is latest to join international consortium with aim to better support target discovery and drug testing with human DRG neurons

The amygdala and alcohol dependence

The amygdala and alcohol dependence

TSRI scientists find that targeting certain neurons can negate alcohol dependence

Treating NASH and AMN with fewer side effects

Treating NASH and AMN with fewer side effects

DeuteRx enters clinical-stage development with DRX-065 after promising preclinical work

Novel mechanism for a new generation

Novel mechanism for a new generation

Idera presents preclinical data demonstrating novel mechanism of action of its third-generation antisense technology

Plasticell and CellSpring seek to validate osteogenic cell therapy and 3D cell culture models

Plasticell and CellSpring seek to validate osteogenic cell therapy and 3D cell culture models

Plasticell, a biotechnology company using combinatorial technologies for stem cell research and optimization of cell and gene therapy manufacturing, has announced it is collaborating with CellSpring

Clinical Trials

Promising data for patients with Crohn’s disease

Promising data for patients with Crohn’s disease

Celgene announces promising top-line data from trial of oral mongersen for both endoscopic and clinical outcomes

Oh, Canada; oh, diabetes

Oh, Canada; oh, diabetes

Sernova seeks FDA approval for U.S. clinical trial on Cell Pouch System for diabetics

Illumina software supports cancer study

Illumina software supports cancer study

Company’s technology is being brought to bear on behalf of the TAPUR Molecular Tumor Board for precision medicine cancer study

Out of the starting gate

Out of the starting gate

A roundup of clinical trial startups and initial breakthroughs

Achillion announces 100-percent SVR in trial evaluating triple combination of odalasvir, AL-335 and simeprevir

Achillion announces 100-percent SVR in trial evaluating triple combination of odalasvir, AL-335 and simeprevir

Achillion Pharmaceuticals Inc. has announced that new interim results from a Phase 2a study being conducted by Alios BioPharma Inc., part of the Janssen Pharmaceutical Companies, were published as part of the abstracts released for the European Association for the Study of the Liver Special Conference held Sept. 23-24 in Paris

Sanofi shines in diabetes and dermatology

Sanofi shines in diabetes and dermatology

Recent study results for Toujeo and Dupixent mark two clinical trial successes this fall

Q&A

Q&A: Working to deal a critical blow to brain cancer in kids

Q&A: Working to deal a critical blow to brain cancer in kids

National Brain Tumor Society talks about its part in launching Project Impact and what that means to the landscape of pediatric brain tumor treatment

Feature

Show Preview: Explore the brain and nervous system at Neuroscience 2016

Show Preview: Explore the brain and nervous system at Neuroscience 2016

After visiting Chicago last year, the Society for Neuroscience brings its annual meeting to the warmer climes of Southern California

Editor's Focus

A different sort of animal magnetism

A different sort of animal magnetism

Where does the target market for drugs intersect with regard to humans and animals...and should it?

Commentary

Pediatric pharmacology, part 2

Pediatric pharmacology, part 2

Thanks to a lack of appropriate trials, pharma, healthcare professionals, government, educators, caring/hopeful parents and others are forced to wing it with drugs not fully vetted in the pediatric population

Guest Commentary: What if mice could be more like humans?

Guest Commentary: What if mice could be more like humans?

In efforts to improve upon the human relevance of mouse-based studies, investigators are increasingly turning to models with genetically introduced human components
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