October 2016 Volume 12, Issue 10
Volume 12, Issue 10 | October 2016
October 2016
In this Issue
Q&A

Q&A: Working to deal a critical blow to brain cancer in kids
National Brain Tumor Society talks about its part in launching Project Impact and what that means to the landscape of pediatric brain tumor treatmentBusiness & Government Policy

Patent Docs: The Trans-Pacific Partnership--What it may mean for the pharmaceutical industry
While the treaty’s principal provisions include lower tariffs and dispute resolution mechanisms, there are several sections related to patent law relevant to the U.S. pharmaceutical industry, and Kevin Noonan explains
Determining cell death
NIH-university collaboration advances potential Zika virus treatments
French connection
Advanced Analytical establishes office in Genopole, France
On the cutting edge
A roundup of instrumentation, software and other tools and technology news
For your approval
A collection of recent regulatory approvals and other actions globallyFeature

Show Preview: Explore the brain and nervous system at Neuroscience 2016
After visiting Chicago last year, the Society for Neuroscience brings its annual meeting to the warmer climes of Southern CaliforniaSpecial Reports

Special Report on Drug Metabolism: Identifying toxicity
Will embracing complexity lead to safer drugs?Editor's Focus

A different sort of animal magnetism
Where does the target market for drugs intersect with regard to humans and animals...and should it?Commentary

Pediatric pharmacology, part 2
Thanks to a lack of appropriate trials, pharma, healthcare professionals, government, educators, caring/hopeful parents and others are forced to wing it with drugs not fully vetted in the pediatric population
Guest Commentary: What if mice could be more like humans?
In efforts to improve upon the human relevance of mouse-based studies, investigators are increasingly turning to models with genetically introduced human componentsResearch & Development

Delving into drug delivery
F-star and Denali to develop multispecific antibody platform for crossing blood-brain barrier
Junk DNA and genomic stability
Duke researchers discover connection between junk DNA variations and increased risk of cancer or other diseases
Four months, four agreements
Selexis inks cell license agreement with Pieris for immuno-oncology bispecific drug candidate
Of eggs and enzymes
‘Egg unboiling’ technology could change the way enzymes are used in research
Getting to the heart of HCM
Stem-cell model of heart condition reveals how the fibrosis is perpetuated
InSphero launches 3D mitochondrial toxicity testing service
InSight Mitochondrial Toxicity Testing provides for the identification of mitochondrial liabilities during drug development and safety testing
First proposal of strategies for validating antibody specificity
The International Working Group on Antibody Validation announced recently the publication of initial strategies developed to address a critical unmet need for antibody specificity, functionality and reproducibilityContract Services

Cinven expands clinical services footprint
Bioclinica acquisition deal marks the first investment with the Sixth Cinven Fund
Calithera selects ProTrials for early-phase trial support
Agreement provides clinical development services for Calithera’s CB-839 oncology therapeutic
Crown Bioscience boosts oncology offerings
Company expands site and services at San Diego Center of Excellence for Oncology
Charles River acquires Agilux Laboratories
M&A deal enhances Charles River’s early-stage capabilities in bioanalytical servicesClinical Trials

Sanofi shines in diabetes and dermatology
Recent study results for Toujeo and Dupixent mark two clinical trial successes this fall
Promising data for patients with Crohn’s disease
Celgene announces promising top-line data from trial of oral mongersen for both endoscopic and clinical outcomes
Oh, Canada; oh, diabetes
Sernova seeks FDA approval for U.S. clinical trial on Cell Pouch System for diabetics
Illumina software supports cancer study
Company’s technology is being brought to bear on behalf of the TAPUR Molecular Tumor Board for precision medicine cancer study
Out of the starting gate
A roundup of clinical trial startups and initial breakthroughs
Achillion announces 100-percent SVR in trial evaluating triple combination of odalasvir, AL-335 and simeprevir
Achillion Pharmaceuticals Inc. has announced that new interim results from a Phase 2a study being conducted by Alios BioPharma Inc., part of the Janssen Pharmaceutical Companies, were published as part of the abstracts released for the European Association for the Study of the Liver Special Conference held Sept. 23-24 in ParisDiscovery

New understanding of cocaine addiction
Recent TSRI study findings suggest pharmacological remedies are possible
Warp speed ahead
Company gets SMART Platform patent for identifying new therapeutic agents naturally
The promise of peroxiredoxin
A protein that clears hydrogen peroxide from cells could offer new options for antibiotics
Stanford and twoXAR team up against liver cancer
Researchers to validate computationally derived drug candidates targeting hepatocellular carcinomaPreclinical

Abeta, pGlu-Abeta and Alzheimer’s
German biopharmaceutical Probiodrug’s preclinical trial takes giant step toward treating Alzheimer’s disease
DRGNET aims for less reliance on animals in pain research
Metrion is latest to join international consortium with aim to better support target discovery and drug testing with human DRG neurons
The amygdala and alcohol dependence
TSRI scientists find that targeting certain neurons can negate alcohol dependence
Treating NASH and AMN with fewer side effects
DeuteRx enters clinical-stage development with DRX-065 after promising preclinical work
Novel mechanism for a new generation
Idera presents preclinical data demonstrating novel mechanism of action of its third-generation antisense technology
Plasticell and CellSpring seek to validate osteogenic cell therapy and 3D cell culture models
Plasticell, a biotechnology company using combinatorial technologies for stem cell research and optimization of cell and gene therapy manufacturing, has announced it is collaborating with CellSpringDiagnostics

A new ANGLE on biopsies
MD Anderson Cancer Center research validates efficacy of Parsortix liquid biopsy system
A federal challenge
NIH competition seeks diagnostic tools to combat antimicrobial resistance
More precision for personalized medicine
Mount Sinai center aims to use computer vision technology for diagnosis and treatment
Breaking new ground with infectious disease
JAX-bioMérieux diagnostics partnership aims at better pathogen identification and countering antimicrobial resistance

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