October 2014 Volume 10, Issue 10

Volume 10, Issue 10 | October 2014

October 2014

In this Issue

Q&A

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Q&A: ‘Making cancer history’

DDNews speaks with Dr. Philip Lorenzi about how MD Anderson Cancer Center guides drug discovery and development via enhanced targets and biomarkers

Feature

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A Capitol affair

Society for Neuroscience stays in its own backyard for this year’s annual meeting, looking to host more than 30,000 attendees

Editor's Focus

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The business of reducing obesity

The effort to reduce obesity (and to profit from that effort) isn’t anything new, but based on my email inbox recently, perhaps we’re about to enter into an era of blockbuster weight-management medications. For the moment, however, we’re at the early stages of any such race, and it looks like Novo Nordisk and Orexigen are fighting for the strong start out of the gate.

Commentary

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Peer review and the life sciences

In an era of "publish or perish," combined with "fund or perish," we may be moving toward an era in which peer review is no longer up to the task, and we end up with too many journals and too little rigor
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Guest Commentary: Factors impacting genome editing success and failure--A focus on cell lines

The ability to create isogenic cell lines in which the genome editing event is the sole differentiator between the phenotypes of two cells is a powerful tool. Despite all the recent developments and improvements in targeting platforms, certain challenges remain, and the role played by the choice of cell line in order to achieve success cannot be overstated.

Business & Government Policy

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Sitting pretty for $17 billion?

Merck KGaA acquiring Sigma-Aldrich to enhance position in increasingly attractive life-sciences market
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Delving into duvelisib

Infinity, AbbVie link up to develop Infinity’s PI3K-delta/gamma inhibitor in oncology
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Lysosomal storage disease could be an attractive market

According to Thomson Reuters, there is economic power in ultra-orphan disease therapies
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Attaching the umbilical cord

Novartis invests $35M in Gamida Cell with eye on stem cell therapies
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On the cutting edge

A roundup of instrumentation, software and other tools and technology news

Clinical Trials

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Cognitive computing in the clinic

Mayo Clinic and IBM to apply Watson to clinical trial enrollment
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Nymox’s prostate cancer candidate progressing apace

NX-1207 continues to show an encouraging safety profile in prostate cancer and BPH
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A new way to go after breast cancer

Spanish lab finds promise in fighting breast cancer with experimental drug nintedanib
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Two is better than one

Bristol-Myers Squibb, Celgene deliver one-two punch to beat breast cancer
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Looking good

Clinical trial shows potential for Auxilium’s CCH for treating cellulite

Discovery

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Carving out new cancer territory

Blueprint Medicines announces discovery of novel oncology drug targets
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Brain cells from skin

Researcher awarded £900,000 to develop an innovative new way to screen potential new treatments for diseases such as Alzheimer’s
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New agreement with Schrödinger a ‘game-changer’

Schrödinger and Tri-I TDI launch a joint agreement to boost early-stage research by young researchers
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Welcome to Discovery Park

New facilities will house drug discovery and bioscience centers
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Aphios scores grant for green drug discovery technology

SBIR grant will fund development of prototype tech to unearth potential therapeutic chemicals in biomass

Diagnostics

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CGI diagnostics added to online test database

Genetic Testing Registry now contains 40 of Cancer Genetics’ proprietary tests
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PDI enters molecular diagnostics market

Acquires thyroid and pancreatic cancer tests as first step toward creation of a molecular diagnostics force in Interpace Diagnostics
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Collaboration to combat cancer

Team develops molecular diagnostic tests in tandem with targeted therapeutics
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Moving to a multiplayer game

Illumina strikes several partnerships to advance oncology diagnostics to panel-based assays

Preclinical

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Reaching for results

Seattle Genetics and Genmab create new ADC collaboration, adding to Genmab’s preclinical pipeline
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Wiping out C. difficile

Synthetic Biologics soon to initiate clinical trials of SYN-004 for deadly C. diff. infections
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Sage presents new preclinical data on antiepileptic drug

Data highlighted at Eilat Conference underscore potential of SAGE-217 to address acute and chronic forms of epilepsy and other seizure disorders
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A printable model for liver disease

Organovo designs and creates functional, 3D human tissues for medical research and therapeutic applications

Research & Development

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Neighbor helping neighbor

Janssen, J&J Innovation serve as catalysts for neuroscience research with University of Toronto on Alzheimer’s disease study
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Enter the zebrafish

CQDM and OCE co-fund neuroscience research collaboration
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Two against endometriosis

SRI International and Nobelpharma partner on endometriosis drug development
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Getting social to report adverse drug reactions

U.K. agency leads EU project on the use of smartphones and social media for drug safety information
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Lucigen and Thermo Fisher team up on next-gen sequencing

Lucigen Corp. and Thermo Fisher Scientific announced in late August that they would partner to release new mate pair library technology for Ion Torrent sequencing
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Driving gene therapy with nonviral vectors 

Learn why nonviral vectors are on the rise in gene therapy development.
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Milestone: Leapfrogging to quantitative, high throughput protein detection and analysis

Researchers continuously push the boundaries of what’s possible with protein analysis tools.
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Advancing immuno-oncology research with cellular assays

Explore critical insights into immunogenicity and immunotoxicity assays for cancer therapies.
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