October 2013 Volume 9, Issue 10

Volume 9, Issue 10 | October 2013

October 2013

In this Issue

Research & Development

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Waiting to inhale

Sweden’s Meda acquires Mass.-based Acton Pharmaceuticals, inhaler Aerospan, in deal worth up to $200 million
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Dollars and antisense

Biogen Idec and Isis Pharmaceuticals collaborate to advance treatment of neurological disorders
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A young man’s game

Stem cells from older donor patients may be less effective than their younger counterparts, according to Tulane University study
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Earning their stripes

Zebrafish continue to gain popularity as lab models for drug discovery
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Amgen’s big bang theory

Seeking to stave off generic competition, Amgen spends $10.4 billion to acquire Onyx and its FDA-approved cancer drug, Kyprolis

Global News

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A real steal?

Otsuka to acquire Astex for about $886 million, which several market-watchers claim undervalues the company
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China’s pharma boom

GlobalData predicts more than 650-percent revenue growth by 2020
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J&J joins amazing race

Johnson & Johnson joins academia and medical charity in Big Pharma’s hunt for Dengue fever vaccine
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Debiopharm eyes antibiotics market

Company teams up with TCG Lifesciences to develop novel class of antibiotics

Clinical Trials

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Heading for a merger

Update Pharma, Resolute Oncology ink binding term sheet
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Getting the numbers right

PhRMA Joins with National Minority Quality Forum and Microsoft to address diversity in clinical trials
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Indiana to advance with Covance

Alliance aims to bring more clinical research to Indiana and provide quicker access to patients in Phase I clinical trials
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GPS for stem cells

America Stem Cell receives FDA clearance for multicenter, dual-umbilical cord transplantation trial
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Tracking the trends

Thomson Reuters’ quarterly report on drugs to watch analyzes trends

Diagnostics

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Pay to play

With acquisition of BioFire, bioMérieux seeks to consolidate position as major player in infectious disease diagnostics
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Bringing flu testing closer to home

Novel testing method brings promise of inexpensive at-home flu test
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Nurturing the next generation

Enzymatics acquires ArcherDx and next-generation diagnostic technology
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Early infection detection

MIT team unveils work on microfluidic device for early-stage malaria detection

Omics & Systems Biology

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‘A clear mechanistic link’

Multi-institute collaboration discovers cascade mechanism underlying Alzheimer’s disease
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NIH launches second phase of Human Microbiome Project

Government earmarks $22.1 million to fund three research studies over three years
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Taking a user snapshot

OGT publishes survey results of researchers using next-generation sequencing
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Risk-takers at Vanderbilt drive drug discovery research

Researchers use Tecan Freedom EVO 200 to provide routine processing of three ADME assays

Tools & Technology

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South-of-the-border buyout

Agilent Technologies signs agreement to acquire assets from ABC Instrumentación Analítica
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Good things come in small packages

Nanomedicine can reduce cost and enhance safety of drug discovery
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Horizon Discovery licenses two gene-editing technologies

Company boosts rAAV gene-editing platforms with technologies from Sigma Life Science and Harvard
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Image is everything

Oncodesign, Banook Central Imaging to develop biomarkers for clinical imaging

Commentary

A guide for potency assay development of cell-based product candidates

The development of a potency assay for cellular therapy products entails many steps of innovations and discoveries, while keeping in mind the end user and the requirements of the regulatory authorities.
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A celebration of instrumentation

The Camille and Henry Dreyfus Foundation sponsors The Dreyfus Prize in the Chemical Sciences. The purpose of the foundation is to “to advance the science of chemistry, chemical engineering and related sciences as a means of improving human relations and circumstances.” This year, the $250,000 Dreyfus prize was, for the first time, focused on chemical instrumentation.

Special Reports

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PCR turns 30 (part one)

One of the most important and widely used processes in biotechnology is going strong as it marks the 30th anniversary of its invention
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PCR turns 30 (part two)

Continuing coverage of special report on PCR

Editor's Focus

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The gravity of the government shutdown’s impact on science

When we went to press with this issue, close to 1 million government workers were furloughed, some members of Congress gave up their salary pay and government agencies key to the welfare of the drugmaking industry went on a hiatus of undetermined length. The NIH in particular was already smacked down by the sequestration earlier this year, losing $1.5 billion out of its already stretched-thin operating budget. Now the bruised-up agency stands to lose an estimated $600 million more when the government reopens.

Products & Services

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High-throughput in-vivo CNS pharmacology screening

High-throughput in-vivo CNS pharmacology screening provides rapid, tailor-made lead validation service using selected in-vivo and ex-vivo assays.
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Hamilton Robotics delivers new high-tech liquid handling platform

The VANTAGE is for simple to complex lab requirements and applications. A single vertically integrated system can easily replace four to six other pipetting robots and provides more functionality than other platforms.
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Larger diameter Kinetex core-shell HPLC prep column enables higher loads for pharma lab-scale purification

Phenomenex announces a new 30 mm internal diameter (I.D.) Kinetex core-shell 5-micron column in Axia hardware for preparative HPLC and SFC in pharmaceutical lab-scale purification.
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MultiFlo FX combines bulk dispel-sing and washing for improved, automated workflows

MultiFlo FX is a fully modular, automat-d reagent dispenser for six- to 1,536-well plates offering BioTek’s unique Parallel Dispense technology—both peristaltic and syringe pump operation down to 500 nL.
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HTG launches two multiplexed gene expression assays for use on award-winning HTG Edge system

The new HTG Edge multiplexed assays for drug and oncology research are the DMPK and TOA Assays.
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Molecular Devices launches ImageXpress Micro XLS system for wide-field high-content screening

Molecular Devices announced today the launch of ImageXpress Micro XLS System, the latest improvement to its high-content screening portfolio.
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Bio-Rad’s ddPCR library quantification kit optimizes performance of Ion Torrent NGS systems

Bio-Rad Laboratories Inc. launched its ddPCR library quantification kit for Ion Torrent library preparation.
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Certara launches Cardiac Safety Simulator to determine arrhythmia risk for drug candidates

Based on an in-silico model of human ventricular heart cells, Certara’s Cardiac Safety Simulator (CSS) helps sponsors to assess arrhythmia risk before a new drug candidate enters clinical trials and determine safe drug doses for specific patient populations.
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96-well microplates with 3D epoxy surface for covalent binding of biomolecules

The 3D epoxy surface of the 96-well microplates is the ideal platform for covalent binding of proteins, peptides, DNA and oligonucleotides
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Th17, Treg, IFN, TLR, NF-B Reporter Cell Lines for drug discovery screening

IMGENEX’s proprietary Reporter Cell Lines provide the most advanced system available for screening Treg, Th17, TLR, STAT3 and inflammatory pathway mediators.
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Accelrys brings next-generation decision-making to scientific discovery with launch of Accelrys Insight

Accelrys Insight and Accelrys Insight for Excel offer research scientists an entirely new way of accessing, visualizing and analyzing data that is locked in disparate locations across internal discovery teams and networked external partners, helping to lower long-standing barriers to bringing innovative therapeutics to market faster and more cost effectively.
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Abcam launches SimpleStep ELISA kits

SimpleStep ELISA kits have a greatly simplified protocol when compared to standard multistep ELISAs, providing significant time savings and ease of use.
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ACD/Labs announces the release of ACD/ChemAnalytical Workbook

ACD/ChemAnalytical Workbook is an all-in-one experiment, workflow and data management tool that allows scientists to document analytical information and benefit from the knowledge gained in future projects.
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Cresset’s new Activity Miner for lead optimization highlights and explains key activity insights

Cresset announces the release of the Activity Miner module for Torch and Forge. Activity Miner is a new intuitive SAR interpretation tool that identifies the key 3D structural and electrostatic changes impacting biological activity.
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Optibrium and AstraZeneca sign agreement for global license of StarDrop

Optibrium, a developer of software for drug discovery, today announced that AstraZeneca has signed an agreement to license Optibrium’s StarDrop software.

Feature

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Eternal sunshine of the spotless mind (part one)

Sunny San Diego plays host to annual meeting of the Society for Neuroscience
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Eternal sunshine of the spotless mind (part two)

Additional pre-show coverage of Neuroscience 2013
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Driving gene therapy with nonviral vectors 

Learn why nonviral vectors are on the rise in gene therapy development.
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Milestone: Leapfrogging to quantitative, high throughput protein detection and analysis

Researchers continuously push the boundaries of what’s possible with protein analysis tools.
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Advancing immuno-oncology research with cellular assays

Explore critical insights into immunogenicity and immunotoxicity assays for cancer therapies.
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