November 2024 Volume 20, Issue 6

Drug Discovery News November 2024 Issue

Volume 20, Issue 6 | November 2024

November 2024

In this Issue

Stem Cells

A fluorescent microscopy image of a mouse pancreatic tumor.

A protein that makes pancreatic stem cells invisible

Researchers showed that pancreatic cancer stem cells produce a protein usually made by neutrophils to evade the immune system and keep growing.

Hematology

A woman rubs her hands.

On the cusp of a CAR T cell cure for lupus

Exhilarated but cautious, researchers are eager to see if CAR T cell therapy offers a one-time treatment for lupus.
A woman with ichthyosis sits at a table working on a laptop.

Old drugs shed new light on a rare skin disease

Drug repurposing trials for ichthyosis reveal complexity in the long-untreated disease.
A doctor attends to a baby in an incubator.

Targeting a clotting protein to treat neonatal brain bleeds

Researchers discovered that a blood clotting protein, fibrinogen, harms brain development during bleeds in preterm infants.

Diagnostics

The human brain, viewed from the side, is shown with pieces disappearing.

Detecting Parkinson’s disease earlier could prevent brain damage

Scores of neurons are already dead by the time Parkinson’s disease is usually diagnosed. Scientists aim to identify patients earlier and intervene before it’s too late.
Electron microscopy images show the system used to measure force.

Playing tug-of-war with platelets 

With new tools, researchers hope to improve diagnosis of platelet dysfunction by measuring their forces.
An illustration of a woman sleeping and surrounded by three floating sheep.

The metabolites that define a bad night’s sleep

The link between metabolism and sleep is helping scientists find new biomarkers to detect sleepless nights and diagnose chronic sleep disorders.

Stem Cells

A cutout of lungs in blue with purple flowers as blooming alveoli.

Rejuvenating lung stem cells for idiopathic pulmonary fibrosis

Michael Bollong and his team discovered a way to restore lung stem cells’ regenerative capacity and a potential drug for idiopathic pulmonary fibrosis.

Editor's Focus

An illustration of bone marrow containing immune and hematopoietic stem cells

Milestone: The history of bone marrow transplantation

In a journey fraught with heartache and persistence, medical research giants paved the way for successful bone marrow transplantation. 
An illustration of cells with orange nuclei and transparent cytoplasm

Explained: What is mesenchymal stem cell therapy?

Born to differentiate and heal, mesenchymal stem cells carry great potential for treating a wide spectrum of diseases.

Editors Insight

Rows of old medicine bottles sit in rows on top of a wooden pharmacy shelf.

Rediscovering forgotten drugs with new AI tools

As scientific output grows, the risk of a promising drug getting lost increases, but advances in artificial intelligence and machine learning may prevent that.

Gene Therapy

A toddler holds an adult’s hands as she walks outside during an autumn afternoon.

Targeting Rett syndrome at the source

Rett syndrome currently has no cure. Now, innovations in gene therapy bring the possibility of treating the root cause of the disease closer than ever before.
An old man sits on a rock that looks like a brain in the middle of the sea. A DNA coil that represents a gene therapy is in the sky.

Gene therapy could treat Alzheimer’s disease

New gene therapies in clinical trials seek to treat Alzheimer’s disease and heal the brain with a dose of helpful genetic material.
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Gold circles with attached purple corkscrew shapes represent gold nanoparticles against a black background.

Driving gene therapy with nonviral vectors 

Learn why nonviral vectors are on the rise in gene therapy development.
A 3D digital illustration of a viral spike protein on a cell surface, surrounded by colorful, floating antibodies in the background

Milestone: Leapfrogging to quantitative, high throughput protein detection and analysis

Researchers continuously push the boundaries of what’s possible with protein analysis tools.
Blue cancer cells attached to a cellular surface against a bright blue background in a 3D rendering of a cancer infection.

Advancing immuno-oncology research with cellular assays

Explore critical insights into immunogenicity and immunotoxicity assays for cancer therapies.
Drug Discovery News November 2024 Issue
Latest IssueVolume 20 • Issue 6 • November 2024

November 2024

November 2024 Issue

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