November 2023- Volume 19, Issue 11

In this Issue

Editor's Focus

A pocket watch with a drawing of a brain in the middle.

Hope for prion diseases

Hope for prion diseases

From reducing prion protein to fighting neuroinflammation, researchers try different techniques to combat deadly prion diseases.
An illustration of a human body with curved dotted lines demonstrating the path of cell migration in a background of various cells

Explained: How do cells migrate? 

Explained: How do cells migrate? 

Cells travel throughout the body, enabling diverse biological phenomena in health and disease.
A scientist wears blue gloves and holds up a bacteria plate with a lawn of red and yellow bacteria on it.

When happy accidents lead to new discoveries

When happy accidents lead to new discoveries

No one ever hopes to mess up an experiment, but sometimes what seems like a frustrating misstep actually sparks a discovery.

Neuroscience

A hand with a red string tied in a bow around the index finger.

The science of forgetting

The science of forgetting

Researchers explore the role of forgetting in normal brain function and as a therapeutic target for fear-related disorders.
A photograph of an old woman’s hands playing the piano.

Musical medicine for Parkinson’s disease

Musical medicine for Parkinson’s disease

By measuring neural oscillations in the brain, Isabelle Buard studies the effect of music therapy on improving fine motor movements in neurological disorders.
Different colored lines ranging from red to blue indicate the trajectories of Fyn proteins within a neuron.

Tracking the movement of individual proteins in dementia

Tracking the movement of individual proteins in dementia

A dementia-associated tau mutation promotes unusual clustering of Fyn, a protein important for learning and memory.

Epigenetics

A mouse mother stands next to her litter of small, furless mouse pups.

Early life adversity leaves marks in the brain

Early life adversity leaves marks in the brain

Negative childhood experiences can leave epigenetic scars that haunt organisms for life.
A black mouse walks along a white surface against a red background.

How heritable is the epigenome?

How heritable is the epigenome?

Isabelle Mansuy explores how life experiences alter the epigenome of an organism and its descendants.
A line of alcoholic drinks in differently-shaped glasses sit on top of a bar.

Deadly alcoholic hepatitis finds hope in epigenetics

Deadly alcoholic hepatitis finds hope in epigenetics

With a high mortality rate and no treatment, alcoholic hepatitis is a tragic diagnosis. But a new molecule that alters patient epigenetics may become the first effective therapy for the disease.

Tools & Techniques

An older woman points to five different pills in the palm of her hand as she stands next to a doctor wearing a stethoscope holding a pill bottle.

A new computational tool predicts drug targets and side effects

A new computational tool predicts drug targets and side effects

Scientists developed a way to probe single cell transcriptomic data to find drugs that target cells of interest and to identify cells targeted by specific drugs.
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