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November 2023

A scientist wears blue gloves and holds up a bacteria plate with a lawn of red and yellow bacteria on it.

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No one ever hopes to mess up an experiment, but sometimes what seems like a frustrating misstep actually sparks a discovery.

When happy accidents lead to new discoveries

An illustration of a human body with curved dotted lines demonstrating the path of cell migration in a background of various cells

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An illustration of a human body with curved dotted lines demonstrating the path of cell migration in a background of various cells.

Cells travel throughout the body, enabling diverse biological phenomena in health and disease.

Explained: How do cells migrate?&nbsp;

Eric Minikel and Sonia Vallabh wear lab coats and safety glasses in their lab at the Broad Institute.

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A pocket watch with a drawing of a brain in the middle. 

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Julie Moreno wears a dark green shirt and a white lab coat while working in her lab.

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Sabine Gilch and Irina Zemlyankina wear gloves and lab coats while working in the lab. 

From reducing prion protein to fighting neuroinflammation, researchers try different techniques to combat deadly prion diseases.

Hope for prion diseases

Editor's Focus

Different colored lines ranging from red to blue indicate the trajectories of Fyn proteins within a neuron. 

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A dementia-associated tau mutation promotes unusual clustering of Fyn, a protein important for learning and memory.

Tracking the movement of individual proteins in dementia

flamenco dancer’s hands lift up in the air playing castanets.

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Isabelle Buard sits in front of two computer monitors with brain imaging data on them. To her left, is a piano keyboard.

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A photograph of an old woman’s hands playing the piano.

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By measuring neural oscillations in the brain, Isabelle Buard studies the effect of music therapy on improving fine motor movements in neurological disorders.

Musical medicine for Parkinson&rsquo;s disease

A microscopy image of dopamine-producing neurons in the fly brain.

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A hand with a red string tied in a bow around the index finger.

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Whitish brain slices are place on a glass microscope slide using a paintbrush. 

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A microscopy image of neurons in the hippocampus.

Researchers explore the role of forgetting in normal brain function and as a therapeutic target for fear-related disorders.

The science of forgetting

Neuroscience

A line of alcoholic drinks in differently-shaped glasses sit on top of a bar.

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An illustration of a healthy liver on the left and a liver with cirrhosis on the right.

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 backlit photo of a young man sniffing a wine glass filled with rosé.

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James Brown, the CEO and President of DURECT, wears a brown blazer and blue striped shirt while standing in front of a brick wall.

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With a high mortality rate and no treatment, alcoholic hepatitis is a tragic diagnosis. But a new molecule that alters patient epigenetics may become the first effective therapy for the disease.

Deadly alcoholic hepatitis finds hope in epigenetics

A mouse mother stands next to her litter of small, furless mouse pups.

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Subhash Pandey wears a white coat and blue gloves while working in the lab.

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An image showing how DNA is wrapped around four histone proteins and then organized into chromosomes.

Angélica Torres-Berrío wears a white lab coat and green gloves while pipetting in the lab.

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Eric Nestler wears a black blazer and smiles in front of a bookcase.

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Negative childhood experiences can leave epigenetic scars that haunt organisms for life.

Early life adversity leaves marks in the brain

A black mouse walks along a white surface against a red background.

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Isabelle Mansuy explores how life experiences alter the epigenome of an organism and its descendants.

How heritable is the epigenome?

Epigenetics

An electrocardiogram of a person’s heartbeat is drawn in a black line over a grid drawn in grey lines.

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An older woman points to five different pills in the palm of her hand as she stands next to a doctor wearing a stethoscope holding a pill bottle.

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Sarah Teichman, Kazumasa Kanemaru, and James Cranley stand left to right in a row on the grass outside of the Wellcome Sanger Institute.

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Scientists developed a way to probe single cell transcriptomic data to find drugs that target cells of interest and to identify cells targeted by specific drugs.

A new computational tool predicts drug targets and side effects

Tools & Techniques

Tackling mycoplasma contamination in biotherapeutic production

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Thermo Fisher Scientific

DNA-based testing is emerging as a sensitive way to uncover and control a hidden threat in biomanufacturing.

Webinars

Surface rendering of two interacting proteins (green and peach) bound together by a small molecule ligand at their interface, illustrating a protein-ligand binding event.

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Salad Technologies

Learn how molecular dynamics, AI-aided design, and structural insights combine to reshape how therapeutic proteins are created, validated, and optimized.

Computational approaches to drug design

Compendium

Stem cells are shown as clear, purple, and blue spheres against a dark blue and black background.

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Diagram showing how patient-derived somatic cells are reprogrammed into iPSCs using Yamanaka factors and then differentiated into specialized cell types such as neurons, cardiomyocytes, and hepatocytes.

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BPS Bioscience

Human-relevant, ready-to-use stem cell models are reshaping drug discovery, toxicity testing, and personalized medicine.

November 2023 Volume 19, Issue 11