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March 2025

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November 2022

A computer-generated image of dendritic cells in blue activating a T cell in pink and purple.

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A photo of Caleb Lareau standing in a laboratory at Stanford University smiling and wearing a multi-colored shirt.

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CAR T cell therapies use engineered T cells to fight cancer, but they can sometimes cause neurotoxic side effects. Herpes virus reactivation in donor CAR T cells may be to blame.

Viral reactivation may cause CAR T cell-induced neurotoxicity

Cell Biology

People with vitiligo lose pigment cells and develop discolored patches of skin.

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There are currently no FDA-approved drugs to treat vitiligo, an autoimmune disease that kills skin pigment cells. But a phase III study of a drug used to treat atopic dermatitis may be the first to get the FDA seal of approval.

A drug that effectively treats vitiligo

Farshid Guilak stands in his laboratory wearing a white lab coat.

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Jin Montclare wears a white lab coat and green gloves as she holds a test tube of her protein-based gel that efficiently delivers osteoarthritis drugs when injected into joints.

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Cartilage cells shown in green and blue are overlayed on an image of a grey, woven scaffold.

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Donagh O'Shea sits at a biosafety cabinet making scaffolds.

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A yellow-colored sphere-shaped gel, which is CytexOrtho's hip-shaped scaffold, sits on top of a white mesh structure.

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Transporting osteoarthritis drugs to the joints is challenging. Innovations in nanoparticle delivery, therapeutic gels, and &ldquo;smart cells&rdquo; may be the answer.

Delivering smart solutions for osteoarthritis

Autoimmune Disease

A cone snail sits in a tank behind a dirty glass. 

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A researcher wearing a black mask and wearing an earring looks at a structure of a protein on a computer monitor.

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Bea Ramiro worked with fishermen to collect cone snails in the central Philippines.

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A Peruvian green velvet tarantula, a large hairy brown spider, sits on a green leaf with one of its legs dangling off the edge.

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Nature&rsquo;s most lethal chemicals offer a new road to pain relief. 

A prescription for venom

Dylan Burnette smiles in a bright blue jacket outside of a white-colored building.

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A microscope image of a heart muscle cell stained in yellow and magenta against a black background.

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Blobs of pink-colored mitochondria are shown next to the Golgi apparatus in blue and actin filaments in orange against a black background.

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Three mouse heart cells are shown with their sarcomeres stained in colors ranging from red to purple on a black background.

A microscope image of two cancer cells against a black background. The DNA of the cells is stained yellow, the endoplasmic reticulum is cyan, and the actin filaments are purple and red.

Armed with beautiful microscope images and new translational assays, Dylan Burnette hopes to discover novel and affordable treatments for heart disease.

Heart cells grow to their own beats

Editor's Focus

Bin He wears a suit and tie and stands in a laboratory. 

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A graphic of an arm with the cooling device implanted and connected to an external pump and control system. A zoomed-in box shows squiggly lines depicting nerve signals that flatten, illustrating the nerve block due to local cooling. 

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Seeking alternatives to pharmacological approaches, researchers apply thermal, electrical, and mechanical stimuli to change nerve signaling and treat pain.

Manipulating nerves to relieve pain without drugs

A photo of bottles of frozen breast milk standing in a freezer.

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A photo of Alex Martinez sitting outside in a dark jacket and a collared shirt.

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A photo of Jason Kralic wearing a dark jacket and a collared shirt smiling.

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A photo of Eric Benner in a white lab coat, tie, and collared shirt against a dark background.

From peptides to sugars to lipids, researchers investigate milk as an untapped source of therapeutics for conditions as diverse as anxiety and infant brain injury.

For neurological disorders, milk-based therapies are on the way

Illustration of electricians fixing electrical outlets connected to a human brain.

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Anti-seizure medications act on different neural targets to prevent epilepsy.

Stopping power surges in the brain

Neuroscience

A drawing of people trapped inside pill bottles. 

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In writing about new pain treatments that could benefit a family member, I was reminded of the real people behind every study and story.

Opioid alternatives

Editors Insight

A black mosquito is shown on pink human skin against a blurred green backdrop. 

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Embrient

Malaria continues to drive urgent research worldwide, with new therapies and tools emerging to combat the parasite&rsquo;s complex lifecycle and global burden.

Discovering deeper insights into malaria research

Posters

Three burgundy round and linear conformations of oligonucleotides are shown against a black background. 

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CN Bio

Researchers can now study oligonucleotide delivery and efficacy in a system that models a real human liver.

Accelerating RNA therapeutic testing with liver microphysiological platforms

Application Note

A 3D-rendered illustration of a eukaryotic cell highlighting organelles such as the nucleus, endoplasmic reticulum, mitochondria, and cytoskeletal structures in pink and purple tones.

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Syncell

Discover how innovative proteomics tools help researchers peer into once inaccessible organelles, allowing for new targets for drug discovery and development.

November 2022 Volume 18, Issue 11