November 2022- Volume 18, Issue 11

In this Issue

Editor's Focus

A microscope image of a heart muscle cell stained in yellow and magenta against a black background.

Heart cells grow to their own beats

Heart cells grow to their own beats

Armed with beautiful microscope images and new translational assays, Dylan Burnette hopes to discover novel and affordable treatments for heart disease.
A Peruvian green velvet tarantula, a large hairy brown spider, sits on a green leaf with one of its legs dangling off the edge.

A prescription for venom

A prescription for venom

Nature’s most lethal chemicals offer a new road to pain relief.

Neuroscience

A photo of bottles of frozen breast milk standing in a freezer.

For neurological disorders, milk-based therapies are on the way

For neurological disorders, milk-based therapies are on the way

From peptides to sugars to lipids, researchers investigate milk as an untapped source of therapeutics for conditions as diverse as anxiety and infant brain injury.
A 3D-rendered image of neurons firing.

Manipulating nerves to relieve pain without drugs

Manipulating nerves to relieve pain without drugs

Seeking alternatives to pharmacological approaches, researchers apply thermal, electrical, and mechanical stimuli to change nerve signaling and treat pain.
Illustration of a human brain and a red electroencephalography arising from one region of the brain.

Stopping Power Surges in the Brain

Stopping Power Surges in the Brain

Anti-seizure medications act on different neural targets to prevent epilepsy.

Cell Biology

A computer-generated image of dendritic cells in blue activating a T cell in pink and purple.

Viral reactivation may cause CAR T cell-induced neurotoxicity

Viral reactivation may cause CAR T cell-induced neurotoxicity

CAR T cell therapies use engineered T cells to fight cancer, but they can sometimes cause neurotoxic side effects. Herpes virus reactivation in donor CAR T cells may be to blame.

Autoimmune Disease

Cartilage cells shown in green and blue are overlayed on an image of a grey, woven scaffold.

Delivering smart solutions for osteoarthritis

Delivering smart solutions for osteoarthritis

Transporting osteoarthritis drugs to the joints is challenging. Innovations in nanoparticle delivery, therapeutic gels, and “smart cells” may be the answer.
People with vitiligo lose pigment cells and develop discolored patches of skin.

A drug that effectively treats vitiligo

A drug that effectively treats vitiligo

There are currently no FDA-approved drugs to treat vitiligo, an autoimmune disease that kills skin pigment cells. But a phase III study of a drug used to treat atopic dermatitis may be the first to get the FDA seal of approval.
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• Volume 18 • Issue 11 • November 2022

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