November 2022 Volume 18, Issue 11

November 2022 Issue Front Cover

Volume 18, Issue 11 | November 2022

November 2022

In this Issue

Cell Biology

A computer-generated image of dendritic cells in blue activating a T cell in pink and purple.

Viral reactivation may cause CAR T cell-induced neurotoxicity

CAR T cell therapies use engineered T cells to fight cancer, but they can sometimes cause neurotoxic side effects. Herpes virus reactivation in donor CAR T cells may be to blame.

Autoimmune Disease

People with vitiligo lose pigment cells and develop discolored patches of skin.

A drug that effectively treats vitiligo

There are currently no FDA-approved drugs to treat vitiligo, an autoimmune disease that kills skin pigment cells. But a phase III study of a drug used to treat atopic dermatitis may be the first to get the FDA seal of approval.
Cartilage cells shown in green and blue are overlayed on an image of a grey, woven scaffold.

Delivering smart solutions for osteoarthritis

Transporting osteoarthritis drugs to the joints is challenging. Innovations in nanoparticle delivery, therapeutic gels, and “smart cells” may be the answer.

Editor's Focus

A Peruvian green velvet tarantula, a large hairy brown spider, sits on a green leaf with one of its legs dangling off the edge.

A prescription for venom

Nature’s most lethal chemicals offer a new road to pain relief.
A microscope image of a heart muscle cell stained in yellow and magenta against a black background.

Heart cells grow to their own beats

Armed with beautiful microscope images and new translational assays, Dylan Burnette hopes to discover novel and affordable treatments for heart disease.

Neuroscience

A 3D-rendered image of neurons firing.

Manipulating nerves to relieve pain without drugs

Seeking alternatives to pharmacological approaches, researchers apply thermal, electrical, and mechanical stimuli to change nerve signaling and treat pain.
A photo of bottles of frozen breast milk standing in a freezer.

For neurological disorders, milk-based therapies are on the way

From peptides to sugars to lipids, researchers investigate milk as an untapped source of therapeutics for conditions as diverse as anxiety and infant brain injury.
Illustration of electricians fixing electrical outlets connected to a human brain.

Stopping power surges in the brain

Anti-seizure medications act on different neural targets to prevent epilepsy.

Editors Insight

A drawing of people trapped inside pill bottles.

Opioid alternatives

In writing about new pain treatments that could benefit a family member, I was reminded of the real people behind every study and story.
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A black mosquito is shown on pink human skin against a blurred green backdrop.

Discovering deeper insights into malaria research

Malaria continues to drive urgent research worldwide, with new therapies and tools emerging to combat the parasite’s complex lifecycle and global burden.
Three burgundy round and linear conformations of oligonucleotides are shown against a black background.

Accelerating RNA therapeutic testing with liver microphysiological platforms

Researchers can now study oligonucleotide delivery and efficacy in a system that models a real human liver.
A 3D-rendered illustration of a eukaryotic cell highlighting organelles such as the nucleus, endoplasmic reticulum, mitochondria, and cytoskeletal structures in pink and purple tones.

Shining light on the subcellular proteome

Discover how innovative proteomics tools help researchers peer into once inaccessible organelles, allowing for new targets for drug discovery and development.
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