November 2021- Volume 17, Issue 11

In this Issue

Editor's Focus

Bionaut Labs develops brain-probing microrobots to treat cancers like brain stem glioma.

Meet the microrobots primed to take down cancer

Meet the microrobots primed to take down cancer

Sperm, bacteria, bubbles, and shuttles are just some of the latest cancer-treating microrobots in development for human use in the next few years.
Maggots used therapeutically are the larvae of Lucilia sericata, or the common blowfly. They are only a few millimeters long.

Larva therapy makes a comeback

Larva therapy makes a comeback

A centuries-old wound-cleaning technique is finding its place in modern medicine.

Editors Insight

Pills Background

Ivermectin is a wonder drug, but not a cure-all

Ivermectin is a wonder drug, but not a cure-all

Before its COVID-19 era hype, ivermectin was already a wonder drug for parasitic infections. Its renewed interest underscores the need for effective COVID-19 treatments and communication on proper research study design and analysis.

Dermatology

Kerecis’ cod skin graft brings relief to patients suffering from chronic wounds.

Fish skin heals the toughest wounds

Fish skin heals the toughest wounds

Researchers from Iceland to Brazil investigate the healing powers of fish skin, providing a low-cost and improved solution for treating wounds.
Ointment on hand. Applying the ointment and emollient cream in the treatment and hydration of the skin

Neosporin may slow wound healing

Neosporin may slow wound healing

The commonly used ointment Neosporin may disrupt skin’s regenerative microbiome, delaying healing.

Cancer

SCLC cells have high levels of DNA damage.

New targets for lung cancer treatment

New targets for lung cancer treatment

A young cancer researcher made a big splash when she discovered that inhibiting DNA damage response proteins sensitizes treatment-resistant lung cancer cells to immunotherapy.
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A new AI tool identifies generic drugs with anticancer potential

A new AI tool identifies generic drugs with anticancer potential

Researchers use machine learning to identify generic drugs that are promising candidates for affordable and accessible cancer treatments.
A promising protein degrader trashed a key oncogenic protein

A promising protein degrader trashed a key oncogenic protein

A promising protein degrader trashed a key oncogenic protein

Targeting oncogenic transcription factors like MYC is challenging, but researchers found a way to target its regulator, WDR5, for degradation, exemplifying the capacity of protein degraders to target the “undruggable.”

Metabolism

Pharmacogenetics informs disease risk, risk of drug toxicity, and potential drug efficacy.

Genetic variation in metabolic genes affects drug responses

Genetic variation in metabolic genes affects drug responses

People metabolize drugs differently, changing the effectiveness and toxicity of drugs between individuals. Genetic testing to identify mutations in metabolic genes that may affect how someone processes a drug is an important step towards precision medicine that is becoming more common in the clinic.
Microscopic image of a cell stained for nuclei (blue), mitochondria (red), and microfilaments (green).

Connecting researchers and patients to cure mitochondrial diseases

Connecting researchers and patients to cure mitochondrial diseases

Philip Yeske was an organic chemist for more than 20 years, but when his daughter died from the rare mitochondrial disorder Leigh Syndrome, he turned to connecting researchers, patients, and law makers to speed the discovery of treatments.

Milestone

Old Syringe with a Box

100 years of insulin: from discovery to delivery

100 years of insulin: from discovery to delivery

The long history of insulin discovery and its development for treating diabetes is marked with determination and serendipity, collaboration and controversy.

Psychiatry

Mother kissing her crying baby

A neurosteroid hope for postpartum depression

A neurosteroid hope for postpartum depression

A pioneer in reproductive psychiatry, Samantha Meltzer-Brody investigates new therapeutics for depression during and after pregnancy.
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Drug safety during pregnancy

Drug safety during pregnancy

Pregnant people with mental health disorders such as depression or bipolar disorder often face an impossible decision: risk their health or their future child's health by discontinuing or continuing their medication.
Growing indoor psylocybin psychedelic mushroom

Psilocybin may effectively treat addiction

Psilocybin may effectively treat addiction

Psilocybin research was "outlawed" in the 70s, but it's back now. It may offer a powerful new tool for treating addictions to substances such as alcohol, cigarettes, and opioids.
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November 2021 Issue Front Cover

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• Volume 17 • Issue 11 • November 2021

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