November 2020- Volume 16, Issue 10
In this Issue
Discovery
A better targeting system
A better targeting system
Genetic study of protein levels in diseases could help pinpoint optimal therapeutic targets
Game-changer
Game-changer
Druggable pocket in SARS-CoV-2 spike protein could stop virus
Getting the lowdown on GLO2
Getting the lowdown on GLO2
Researchers publish new data on the enzyme glyoxalase II and its role in cellular metabolism
Finding new drugs with fungi
Finding new drugs with fungi
NIH grant will help researchers learn ways to counter drug resistance via gene editing
Arctoris and Syntekabio form research partnership
Arctoris and Syntekabio form research partnership
First step is to assess potential therapeutics for COVID-19
Clinical Trials
Targeting beta amyloid oligomers
Targeting beta amyloid oligomers
Four compounds show promise against Alzheimer’s
Medable offers fully remote options
Medable offers fully remote options
Informed consent and re-consent made possible for trials without being physically present
Special delivery
Special delivery
Natural compound attacks Alzheimer’s disease early
Commentary: Adapting to a decentralized model during COVID-19 and beyond
Commentary: Adapting to a decentralized model during COVID-19 and beyond
Even after the coronavirus is tamed, changes being made now to clinical trial design and execution could benefit the clinical research industry moving forward
Editor's Focus
Science on fast-forward
Science on fast-forward
Many don’t realize how little “settled science” we’ve got, and the last nine months have brought science out front on a new scale
Keeping tabs on infectious disease
Keeping tabs on infectious disease
A look at our new online venue for infectious diseases as well as upcoming coverage
Research & Development
Pressure to deliver
Pressure to deliver
Researchers pave a way toward painless transdermal drug delivery
An antisense-ible arrangement
An antisense-ible arrangement
Evotec and Secarna partner on antisense-based therapeutics
Building a database around RNA and proteins
Building a database around RNA and proteins
eCLIP technology helps uncover how RNA binding proteins regulate gene expression
Developing a cell therapy control switch
Developing a cell therapy control switch
Nutrient-based safety switches can be applied to CAR-T, stem cell and TCR therapies
Preclinical
Preclinical pancreatic cancer partnership
Preclinical pancreatic cancer partnership
Relationship targets use of pipeline drug and AI platform
BioNTech and Pfizer report BNT162b2 data
BioNTech and Pfizer report BNT162b2 data
BNT162b2 immunization of rhesus macaques results in strong antiviral effects against SARS-CoV-2
New means for managing myotonic dystrophy
New means for managing myotonic dystrophy
RNA-targeting gene therapy reverses molecular and functional features of DM1 in mice
Hope for frontotemporal dementia patients
Hope for frontotemporal dementia patients
Passage Bio plans Phase 1/2 trial of gene therapy in humans based on preclinical results
Feature
Focus Feature on Cancer Research News: Cellular insights into cancer
Focus Feature on Cancer Research News: Cellular insights into cancer
Understanding behavior, responses and evolution of cells aids in oncology efforts
Spotlight on Cell Biology: Cell biology takes the stage
Spotlight on Cell Biology: Cell biology takes the stage
ASCB|EMBO annual meeting goes virtual this year with cellular research. Two of the most significant changes aside from the online format are that the meeting will feature seven scientific tracks plus an education and professional development track, in addition to member-organized Special Interest Subgroups being held on three days of the meeting.
Diagnostics
A promising biomarker for diagnosing liver disease
A promising biomarker for diagnosing liver disease
Owlstone study pinpoints limonene for early diagnosis of NASH and NAFLD
Keeping an eye on neurodegeneration
Keeping an eye on neurodegeneration
Potential biomarker for Alzheimer’s, Parkinson’s and other diseases can be found in the eye
Bionano Genomics acquires Lineagen
Bionano Genomics acquires Lineagen
Deal boosts capacity in digital cytogenetics and adds genetic diagnostics for neurodevelopmental disorders
Contract Services
An acquisition opportunity for CMOs?
An acquisition opportunity for CMOs?
Indian dose sites an untapped M&A opportunity for foreign contract manufacturers
Europital expands into a full-service CRO
Europital expands into a full-service CRO
New capabilities include project management, clinical monitoring and pharmacovigilance
Business & Government Policy
A seed fund to drive biopharma innovation
A seed fund to drive biopharma innovation
Pistoia Alliance looks to finance four projects annually from idea to proof of concept
On the cutting edge
On the cutting edge
A roundup of instrumentation, software and other tools and technology news
Returning to the fold
Returning to the fold
Illumina acquires cancer-focused GRAIL for $8 billion
No more EUAs for COVID-19 tests
No more EUAs for COVID-19 tests
FDA makes a change in its policy of reviewing and granting tests related to the pandemic
