November 2020- Volume 16, Issue 10

In this Issue

Discovery

A better targeting system

A better targeting system

A better targeting system

Genetic study of protein levels in diseases could help pinpoint optimal therapeutic targets
Game-changer

Game-changer

Game-changer

Druggable pocket in SARS-CoV-2 spike protein could stop virus

Getting the lowdown on GLO2

Getting the lowdown on GLO2

Researchers publish new data on the enzyme glyoxalase II and its role in cellular metabolism

Finding new drugs with fungi

Finding new drugs with fungi

NIH grant will help researchers learn ways to counter drug resistance via gene editing

Clinical Trials

Targeting beta amyloid oligomers

Targeting beta amyloid oligomers

Four compounds show promise against Alzheimer’s

Medable offers fully remote options

Medable offers fully remote options

Informed consent and re-consent made possible for trials without being physically present

Special delivery

Special delivery

Natural compound attacks Alzheimer’s disease early

Commentary: Adapting to a decentralized model during COVID-19 and beyond

Commentary: Adapting to a decentralized model during COVID-19 and beyond

Even after the coronavirus is tamed, changes being made now to clinical trial design and execution could benefit the clinical research industry moving forward

Editor's Focus

Science on fast-forward

Science on fast-forward

Science on fast-forward

Many don’t realize how little “settled science” we’ve got, and the last nine months have brought science out front on a new scale
Keeping tabs on infectious disease

Keeping tabs on infectious disease

Keeping tabs on infectious disease

A look at our new online venue for infectious diseases as well as upcoming coverage

Research & Development

Pressure to deliver

Pressure to deliver

Pressure to deliver

Researchers pave a way toward painless transdermal drug delivery

An antisense-ible arrangement

An antisense-ible arrangement

Evotec and Secarna partner on antisense-based therapeutics

Building a database around RNA and proteins

Building a database around RNA and proteins

eCLIP technology helps uncover how RNA binding proteins regulate gene expression

Developing a cell therapy control switch

Developing a cell therapy control switch

Nutrient-based safety switches can be applied to CAR-T, stem cell and TCR therapies

Preclinical

Preclinical pancreatic cancer partnership

Preclinical pancreatic cancer partnership

Relationship targets use of pipeline drug and AI platform

BioNTech and Pfizer report BNT162b2 data

BioNTech and Pfizer report BNT162b2 data

BNT162b2 immunization of rhesus macaques results in strong antiviral effects against SARS-CoV-2

New means for managing myotonic dystrophy

New means for managing myotonic dystrophy

RNA-targeting gene therapy reverses molecular and functional features of DM1 in mice

Hope for frontotemporal dementia patients

Hope for frontotemporal dementia patients

Passage Bio plans Phase 1/2 trial of gene therapy in humans based on preclinical results

Feature

Diagnostics

A promising biomarker for diagnosing liver disease

A promising biomarker for diagnosing liver disease

Owlstone study pinpoints limonene for early diagnosis of NASH and NAFLD

Keeping an eye on neurodegeneration

Keeping an eye on neurodegeneration

Potential biomarker for Alzheimer’s, Parkinson’s and other diseases can be found in the eye

Bionano Genomics acquires Lineagen

Bionano Genomics acquires Lineagen

Deal boosts capacity in digital cytogenetics and adds genetic diagnostics for neurodevelopmental disorders

Contract Services

An acquisition opportunity for CMOs?

An acquisition opportunity for CMOs?

Indian dose sites an untapped M&A opportunity for foreign contract manufacturers

Europital expands into a full-service CRO

Europital expands into a full-service CRO

New capabilities include project management, clinical monitoring and pharmacovigilance

Business & Government Policy

A seed fund to drive biopharma innovation

A seed fund to drive biopharma innovation

Pistoia Alliance looks to finance four projects annually from idea to proof of concept

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

Returning to the fold

Returning to the fold

Illumina acquires cancer-focused GRAIL for $8 billion

No more EUAs for COVID-19 tests

No more EUAs for COVID-19 tests

FDA makes a change in its policy of reviewing and granting tests related to the pandemic
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• Volume 16 • Issue 10 • November 2020

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