November 2018- Volume 14, Issue 11

In this Issue

Business & Government Policy

Patent Docs: Obviousness remains uncertain patentability standard

Patent Docs: Obviousness remains uncertain patentability standard

Public policy regarding innovator drug products need regulatory exclusivities outside mere patent protection in order to provide necessary incentive for further pharmaceutical innovation

Targets acquired

Targets acquired

A look at some recent M&A and licensing deals in the pharma/biotech world

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

Phase II SBIR grant awarded to Celldom

Phase II SBIR grant awarded to Celldom

Money supports advancing tech to process phenotypic and genotypic cell data at massive scale

Editor's Focus

Editor’s focus: The balance between ROI and R&D

Editor’s focus: The balance between ROI and R&D

Are price controls the best way to rein in drug costs, or do we perhaps need to dig deeper into the issue of what is required to bring drugs to market to begin with?

Commentary

Out of order: Beyond the bubble

Out of order: Beyond the bubble

There is an increasing shift with pharma/biotech researchers and execs not just speaking about platforms and performance but also focusing more intently on people and impacts on daily lives

Guest Commentary: The right way to use genetic information in clinical trials

Guest Commentary: The right way to use genetic information in clinical trials

When differences in genetic variants are accounted for in clinical trial design, interventional trials can become much more successful for particular patient groups

Discovery

Repurposing for neglected diseases

Repurposing for neglected diseases

Data collection of existing small-molecule drugs could expedite potential therapies

The promise of retinoic acid signaling

The promise of retinoic acid signaling

Research team publishes research on the anticancer effects of retinoic acid on cancer stem cells

Biological engineers discover new antibiotic candidates

Biological engineers discover new antibiotic candidates

Screen of human proteins by MIT researchers reveals some with antimicrobial power

An ion channel drug discovery

An ion channel drug discovery

Metrion Biosciences awarded funding under Innovate UK Biomedical Catalyst Primer Award

ProMIS tackles Parkinson's and Alzheimer’s diseases

ProMIS tackles Parkinson's and Alzheimer’s diseases

Company has high hopes for antibody candidates targeting toxic oligomers

Feature

Focus Feature on CRISPR: Deals advance CRISPR technology

Focus Feature on CRISPR: Deals advance CRISPR technology

Companies and academic institutions work together to unlock cellular reprogramming, single cell RNAseq-linked screening, stem cell-derived therapies for diabetes, engineered mammalian cell lines and more

Show Preview for ASCB/EMBO 2018: Twice as nice

Show Preview for ASCB/EMBO 2018: Twice as nice

ASCB and EMBO host their second collaborative meeting focused on cell biology

Q&A

Q&A: New standards for IPF

Q&A: New standards for IPF

Dr. Wim Wuyts of University Hospitals Leuven discusses with DDNews how updated guidelines for diagnosing IPF offer physicians more clarity, and how Genentech's Esbriet was found to improve lung function in IPF patients

Clinical Trials

Attaining adhesion

Attaining adhesion

KB103 yields functional collagen production and sustained wound healing in chronic blistering patients

Therapy triumph

Therapy triumph

DNA immunotherapy and checkpoint inhibitor combination lead to remission

Out of the starting gate

Out of the starting gate

A roundup of clinical trial startups and progressions

Recruitment in the digital age

Recruitment in the digital age

Study reveals that ‘traditional digital advertising rules don’t apply’ in clinical trial recruitment

Preclinical

And the sheep shall lead them...

And the sheep shall lead them...

Day-blind sheep bring potential relief for human eye conditions into focus

Possible FOP therapy shines in preclinical study

Possible FOP therapy shines in preclinical study

BLU-782 offers hope for patients with difficult-to-target genetic disease that turns muscle to bone

Of antigens and antitumor effects

Of antigens and antitumor effects

Preclinical efficacy data of Apogenix’s HERA-CD40L published in Journal of Immunotherapy

Starving tumors

Starving tumors

Moleculin announces new data discovery for presentation at Society for Neuro-Oncology meeting

Ablexis inks licensing deal with Memorial Sloan Kettering

Ablexis inks licensing deal with Memorial Sloan Kettering

Agreement grants rights to research, develop and commercialize antibodies generated using AlivaMab Mouse platform

Contract Services

CrownBio expands model options in cancer and more

CrownBio expands model options in cancer and more

Company completes validation of prostate cancer PDX model and forms alliance with Shanghai Model Organisms Center

CMOs to benefit from double-digit approvals for ADCs

CMOs to benefit from double-digit approvals for ADCs

CPhI Annual Report predicts that therapeutic ADC market will reach $4 billion by 2023

Global CRO signs agreement with OmniComm Systems

Global CRO signs agreement with OmniComm Systems

Seven-year TrialOne agreement expands commitment to supporting early-phase studies

Research & Development

Gene, drug and environment interactions

Gene, drug and environment interactions

New modeling provides a more accurate analysis of complex genetic and drug/environment data

Biomarkers for autism

Biomarkers for autism

QBM-001 for non-verbal children set for clinical trials in 2019

Themis pursues oncolytic virotherapies with Max-Planck

Themis pursues oncolytic virotherapies with Max-Planck

Themis Bioscience plans to expand measles vector immunomodulation portfolio into oncology indications

It’s just an expression

It’s just an expression

Multicenter research team hopes modeling gene expression will answer questions about diseases

Attacking substance use disorder

Attacking substance use disorder

BioCorRx, forms deal with VDM Biochemicals for opioid antagonist

Diagnostics

Biogen boosts multiple sclerosis research

Biogen boosts multiple sclerosis research

Evidence supports serum neurofilament light as useful biomarker; Biogen and Siemens to develop blood test

Targeted TMB assessment

Targeted TMB assessment

MolecularMD validates Thermo Fisher assay that can help in trial stratification

UC Davis and NeuroPointDX to launch biomarker panel

UC Davis and NeuroPointDX to launch biomarker panel

New test will target autism diagnosis for children as young as 18 months

Special Reports

Special Report on Molecular Diagnostics: Prenatal probing

Special Report on Molecular Diagnostics: Prenatal probing

Cancer characterization breakthroughs lead to advances in understanding of and techniques for fetal monitoring
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