November 2016 Volume 12, Issue 11

Volume 12, Issue 11 | November 2016

November 2016

In this Issue

Business & Government Policy

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Patent Docs: Scope of Hatch-Waxman ‘safe harbor’ remains unclear

The question of whether activities undertaken post-approval are subject to the act has not been subject to Supreme Court review and recently it declined such review in a specific case
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Next- generation cancer partnership

Investigational therapy uses an oncolytic virus platform to infect and break down cancer
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Off the shelf and into the lab

Fate Therapeutics and Memorial Sloan Kettering to develop off-the-shelf T cell product candidates
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On the cutting edge

A roundup of instrumentation, software and other tools and technology news

Discovery

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Tarveda licenses HSP90 drug conjugate platform

Deal with Madrigal Pharmaceuticals could be worth in excess of $249 million
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The eyes have it

Indiana U. wins $1.9M NIH grant for blindness prevention through research on photoreceptors
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Companies join forces to improve R&D

drug discovery, drug development, R&D
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A new partnership ‘Blooms’ for 3D models

Plasticell and CellSpring collaborate on tissue models for drug candidate screening
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U.K. drug discovery landscape in fundamental shift

According to a new report, the British drug arena is headed more toward collaboration and open innovation

Clinical Trials

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Managing migraine

Drug treats migraine symptoms without cardiovascular risk
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Going after Crohn’s and colitis

Celgene announces positive data from two studies of oral therapies for the gastrointestinal conditions
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Romosozumab impresses in osteoporosis trial

FRAME study demonstrates effectiveness of drug that binds and inhibits activity of sclerostin
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A Phase 1, 2 punch to Parkinson’s disease

Phase 1 clinical trial shows PXT002331 to be a potential weapon against Parkinson’s disease
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An ACTIVE accomplishment

Radius’ abaloparatide-SC reduces fractures, boosts bone mineral density in postmenopausal women with osteoporosis

Editor's Focus

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An update on Cancer Moonshot efforts

The Cancer Moonshot program launched in January by President Barack Obama is something we've been covering here and there in DDNews, and now we catch you up on some of the latest activities

Commentary

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Out of order: Being human

There is certainly value to finding ways to alleviate some of the most challenging and debilitating aspects of autism, but DDNews Features Editor Randall C Willis offers a suggestion: Maybe we shouldn't be trying to actually 'cure' autism per se
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Guest Commentary: Accelerating discovery through contract chemical synthesis

Contract chemistry laboratories are playing an increasingly important role in pharma R&D, and Jeremiah Malerich and colleagues from SRI International share their insights about the role contract chemistry plays in drug discovery

Feature

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ASCB 2016 Show Preview: Following the arc of scientific discovery

American Society for Cell Biology 56th annual meeting headed for San Francisco

Research & Development

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‘A one-step, one-flask process’

Scientists stumble upon revolutionary process in drug design and synthesis
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Headway on HIV

TSRI identifies Env ‘holes’ and bnAbs as potential new approaches in targeting HIV
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A duo for single-cell sequencing

TTP Labtech/UC San Diego collaboration accelerates single-cell genomics research
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Pair of grants for a protein program

Inventiva nets €2.3 million to pursue YAP/TEAD research

Preclinical

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A new option for Sanfilippo?

Abeona’s preclinical data support gene therapy for rare disorder MPS IIIA
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Vaxonella vs. Zika

Prokarium seeks to develop world’s first oral vaccine against Zika virus
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A new cancer combination

AsiDNA and PARP inhibitors demonstrate synergistic effect, bypass genetic restriction
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It’s all in the presentation

A quick roundup of some recent preclinical data presentations

Diagnostics

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Putting cancer breath test through the paces

Owlstone Medical embarks on world’s largest clinical trial for breath-based lung cancer detection
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Bone breakthrough

Austrian company demonstrates miRNA-based test for early detection of osteoporosis
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Cancer Genetics and BARC launch partnership

Initial focus will be on immuno-oncology, hematological cancers and lung cancer
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Meeting up for MDx

New Agilent/Burning Rock deal to focus on cancer diagnostics

Contract Services

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Bracket gets random with integrated PBD technology

Clinical trial tech and services company becomes first clinical IRT provider to natively integrate PBD
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PAREXEL acquires ExecuPharm to broaden functional service depth

Deal is part of ongoing effort to serve a broader customer base of varying sizes with varying abilities
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Ideathon makes an ‘Inspiring’ first showing

The ‘Inspiring Hope’ Ideathon crowdsources ideas for boosting clinical trial awareness and participation
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Exco InTouch boasts quadrupled growth

September saw Exco InTouch celebrate its recognition on the Sunday Times Hiscox Tech Track 100
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An illustration of three immune cells attacking a cancer cell, representing the mechanism of chimeric antigen receptor-based cell therapy

Cell therapy's next frontiers

As cell therapy evolves rapidly, what advancements are on the horizon? 
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Reversing rejection: gene therapy in modern transplantation

Emerging gene editing approaches pave the way for safer, more successful transplants.
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Identifying druggable therapeutic targets

Effective target identification is central to drug discovery, but finding the right drug target is not as simple as it may seem in theory. 
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