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May 2024 Volume 20, Issue 3

Volume 20, Issue 3 | May 2024

May 2024

In this Issue

Aging

A close-up of a scientist’s hands in black gloves holding an obscured object under a microscope.

Reproductive aging leads to many women’s health problems

Slowing female reproductive aging could be the key to improving women’s health.

An illustrated image of an older woman looking at a younger version of herself with a clock behind them, representing reversing immune system aging

Explained: At what age does the immune system weaken?

After decades of combating daily assaults, the immune system undergoes dramatic changes that drastically affect human health.

Five cartoon vials of blood with a doctor holding a magnifying glass to one

Young blood reverses aging in old organs

Young blood rejuvenates aging organs in rodents. Researchers are studying the potential to use young blood-based treatments in aging humans too.

RNA

A 3D rendering of a yellow lipid nanoparticle holding an mRNA therapeutic is shown entering a pink human cell.

Moderna’s path to mRNA therapies for rare metabolic disorders

Paolo Martini leads the biotech company’s rare disease research program with the hope of developing the very first treatments for genetic metabolic disorders.

A microscopic view of white, orange, and green molecules

Silencing genes to prevent disease with RNAi drugs

Alnylam Pharmaceuticals develops therapeutics based on the RNA interference (RNAi) pathway discovered in 1998.

Editor's Insight

Science needs creativity

The pursuit of scientific knowledge relies on analytical thinking, but creativity also plays an essential role.

Editor's Focus

White bowls with brown circular objects on a brown wooden background

A new Goldilocks drug class: macrocyclic peptides

By making peptides ring shaped, researchers uncovered a new class of drugs that is “just right” for previously undruggable targets.

Cell Therapy

Two Antion Biosciences researchers look at a fluorescent image on a computer monitor while wearing white lab coats and purple gloves.

Silencing cancer with CAR T cells

A new approach to cell engineering could make off-the-shelf CAR T cell therapies a reality.

Inside the robotic cluster at Multiply Labs

The robots making cell therapies

Scientists and engineers teamed up to use robots to streamline cell therapy manufacturing, aiming to give more patients access to these lifesaving therapies.

Protein Drugs

A scientist at Entact Bio works in the laboratory.

Targeting disease proteins with molecular matchmakers

Many diseases cause proteins to go haywire. Scientists are now developing drug molecules to change that.

Sponsored

Close-up illustration of clustered, irregularly shaped 3D cell structures resembling organoids, displayed in a blue-toned background.

Automating the counting of 3D cell cultures

Machine learning-powered image analysis makes it possible to automatically and reliably quantify complex 3D cell structures.

Webinars

Illustration of a glowing human brain with interconnected neural networks and bright data points, set against a dark, digital background.

Imaging neural activity in action

Take a closer look at modern techniques that reveal when, where, and how neurons communicate in real time.

Infographics

Gloved hand holding a petri dish containing red liquid culture medium against a light blue background.

Building complex in vitro models to support new approach methodologies

As global regulations shift toward animal-free testing, how can researchers develop more biologically relevant in vitro models to advance drug discovery?