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November 2024

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May 2023

A blue mouse embryo section, with human cells that are labeled green.

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Jun Wu wears a lab coat and a mask while working in the lab.

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Jian Feng wears a white shirt and glasses and sits at a microscope.

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On the left is a normally developing mouse embryo, on the right is a slightly larger mouse embryo that also contains horse cells that glow green.

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Two white mice with patches of brown fur face the camera.

Animals with human cells could provide donor organs or help us understand neuropsychiatric disorders.

Chimera research opens new doors to understanding and treating disease

A woman wearing a blue shirt, beige coat, and white purse examines pasta on a supermarket shelf. 

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A headshot of Franziska Ersoy wearing a blue button-up shirt. 

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A bundle of wheat, a burlap sack full of grain, a pile of grain, and wooden bowl filled with flour sit atop a wooden surface. 

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A headshot of Dan Leffler wearing a blue gingham shirt and a gray jacket. 

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A rainbow protein structure of the kumamolisin-As enzyme. 

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A blue 3D rendering of the human digestive system shows the small intestine in orange and a zoomed-in image of the intestinal villi. 

Researchers develop gluten-degrading enzymes to administer as drugs or incorporate into food and explore therapies that block downstream disease checkpoints.

Taming the immune response to gluten to treat celiac disease

Biologics

A microscopic view of a family of four tardigrades of the species Hypsibius exemplaris swimming in a water droplet.

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Tyler Gonzalez points to a tardigrade in its tun state on a computer monitor attached to a microscope in Thomas Boothby’s laboratory at the University of Wyoming. Shraddha KC sits at the microscope and looks at the monitor.

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Kazuharu Arakawa stands in front of multiple computer servers with a stuffed brown tardigrade on his shoulder.

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Roger Chang stands next to a lab bench in his laboratory at the Albert Einstein College of Medicine

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A microscopic view of a tardigrade is shown over a black background. Fluorescent green and red markers tag specific proteins in the tardigrade’s cells.

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Gary Pielak stands next to a microscope in his laboratory at the University of North Carolina Chapel Hill, holding a blue plushy tardigrade.

Tardigrades survive heat, freezing, and even space radiation. Now, researchers translate lessons learned from these creatures into more stable drug formulations and new health insights.

Tardigrades protect proteins on the brink of death

Editor's Focus

Kate Creevy wears maroon scrubs and examines a small black and white dog standing on a blue table. 

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Daniel Promislow and Matt Kaeberlein stand in a field of purple flowers with three dogs. 

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Two dark brown laboratory mice stand on a white surface.

Biogerontologist Matt Kaeberlein studies aging pets to determine how to improve healthspan in dogs and their humans.

Aging dogs provide insights for human longevity

Blue and green droplets of organoids against a black background.

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Linda Griffith wears a black shirt against a backdrop of plants.

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Nihan Kilinc, Lauren Pruett, Heather George, Samantha Holt, Maria Hernandez, and Ellen Kan wear lab coats and gloves while working in the lab.

Bioengineer Linda Griffith creates tissue models to figure out what causes endometriosis and how to treat it.

Unraveling the molecular mechanisms of endometriosis

Disease Models

Professional portrait of researcher Andres Hidalgo  

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Illustration of macrophage cells targeting smaller illustrated pathogens in red and blue.

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Circadian rhythm concept illustration with tiny characters. Day and night cycle scheme. Daily human body inner regulation schedule. Natural sleep and wake biological process. Abstract cartoon vector illustration.

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Healthcare professional vaccinating a masked woman with curly hair with a shot in the right arm. 

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A person touches the leaves of a Mimosa pudica plant, causing the leaves to fold inward.

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The success of vaccines and cancer treatments varies depending on the time of day they are delivered. Researchers now look to exploit circadian rhythms to improve health outcomes.

Immunologists hack body rhythms for medicine

An image of Anna Blakney, a bioengineer at the University of British Columbia.

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An image of Magnus Hoffmann, a biochemist at the California Institute of Technology.

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A syringe injects a vaccine from a vial bottle. 

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An image of Aliasger Salem, a pharmaceutical scientist at the University of Iowa.

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An image of Jinjun Shi, a cancer biologist at Brigham and Women’s Hospital

Pioneering approaches transform vaccine technologies and shape the future of disease prevention.

A new era of vaccine development

Immunology

A circle of many arms in business attire extended towards one another, hands stacked on top of each other. 

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We should work to dispel the myth of the lone genius and embrace collaboration.

In science, we go farther together

Editors Insight

A silhouette of a man gazing at the Milky Way, symbolizing spatial biology where scientists explore the spatial arrangement of cells

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10x Genomics

Spatial biology adds a new layer of knowledge to unsolved biological questions.

Journeying through cells&#39; spatial dimensions&nbsp;

Compendium

A conceptual illustration of a drug capsule filled with microchips, representing the integration of artificial intelligence in drug discovery and development

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MilliporeSigma

Learn practical strategies for using artificial intelligence to find the best drug candidate.

A Technology Guide for AI-Enabled Drug Discovery

Technology Guides

A blue swirled abstract representation of particle transfer showing a 3D rendering of big data transfers. 

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Thermo Fisher Scientific

Advanced LIMS software helps researchers reliably manage complex bioanalytical workflows and data.&nbsp;

May 2023 Volume 19, Issue 5