May 2022 Volume 18, Issue 5

DDN May 2022 Issue 5 Volume 18 Front Cover

Volume 18, Issue 5 | May 2022

May 2022

In this Issue

Immunology

Cell attacking a virus or cancer

Immune responses in young mice cause early T cell exhaustion against tumors

In children, T cells effectively combat acute infections such as COVID-19, but a new study in mice suggests that the T cell response is detrimental when fighting pediatric tumors.
Discover how immune response is dysregulated in autoimmune diseases.

Explained: How do autoimmune disorders arise?

At the frontline of an autoimmune attack are rogue immune cells turned foe against the body they were created to protect. Scientists study the complex etiology of autoimmune disorders to restore the broken balance.

Gene Therapy

A fluorescent image of an eye with the retina in dark blue and the BDNF receptor in light blue is shown against a black background.

Multiple mutations may no longer stump gene therapies

Creative solutions may enable gene therapy for more common diseases.
Illustration of hands using scissors and tweezers to cut and arrange strands of DNA.

A custom CRISPR solution

Engineered particles improve the efficiency of base editor delivery.

Editor's Insight

Detective supplies including a hat, magnifying glass, map, aged paper, ink, and a writing quill sit on a wooden desk.

Scientific research is a series of infinite mysteries

Like detectives collecting evidence to solve a case, scientists perform experiments to unravel the mysteries of life.

Ophthamology

A collagen fiber floats in front of the retina in a close-up image of the eye, often called an eye floater.

Safer eye floater treatments come with a burst of nanobubbles

Between invasive surgery or risky laser therapy, people suffering from severe eye floaters have no great treatment options. Now, with the development of a safer and less invasive nanoparticle-based therapy, people with floaters may finally get their vision and quality of life back.
Prosthetics send messages between the eye and brain to help blind patients see

Bionic eyes: Treatments for blindness target the retina and the brain

Researchers are developing gene and cell therapies and prosthetics to help patients with blindness regain some vision. The first major prosthetic, the Argus II, was just discontinued. Where will the field go from here?

Diagnostics

Pictures of bugs and butterflies are drawn on clear plastic sheets which will shrink down to miniature drawings when heated. They are a common children's toy called Shrinky Dinks.

Shrinking toys inspire diagnostics and wearable sensors of the future

Inspired by toys from her childhood, bioengineer Michelle Khine designs microscale diagnostics and wearable biosensors with the hope of revolutionizing how people monitor their health.
An ultrasound image of a liver is shown.

Goodbye biopsies, non-invasive diagnostics for fatty liver disease are here

Through academic, industry, and governmental partnerships, scientists validate and develop non-invasive diagnostics for non-alcoholic fatty liver disease. These tests are set to replace the invasive and risky gold standard: liver biopsy.
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A network of interconnected human icons overlaid on a world map, representing global collaboration and population-scale data connections.
New collaborative initiatives are bringing pharmaceutical R&D together around large-scale datasets to accelerate therapeutic discovery.
Modeling neurotropic viral infections using human cerebral organoids
Using fetal-stage brain organoids, researchers are uncovering how Zika virus impacts neurodevelopment and contributes to microcephaly. 
Completing the real-time data picture in bioprocess development
Explore approaches to integrating timely protein titer measurements with cell health data to improve bioprocess visibility and decision-making.
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