May 2015- Volume 11, Issue 5

May 2015

In this Issue

Business & Government Policy

Two’s company; three’s a crowd?

Two’s company; three’s a crowd?

Mylan makes $29-billion offer for Perrigo, inspiring Teva to make $40-billion offer for Mylan

Big changes for Coronado

Big changes for Coronado

Company changes name to Fortress Biotech and makes some key deals in oncology

Patent Docs: FDA approves Sandoz’s filgrastim biosimilar drug product

Patent Docs: FDA approves Sandoz’s filgrastim biosimilar drug product

Many have pontificated about the benefits of a biosimilar approval pathway in the United States; those predictions have begun the process of being tested with approval of Zarxio

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

The M&A roundup

The M&A roundup

Recent merger and acquisition activity in pharma and biotech

Getting to the heart of gene therapy

Getting to the heart of gene therapy

Bristol-Myers Squibb and uniQure to explore gene therapy for cardiovascular diseases

Commentary

Out of order: Asilomar remembered

Out of order: Asilomar remembered

Consensus tends to be lacking as to the dividing line between permissible germline genome modification to treat human disease vs. questionable attempts at human enhancement, and that is something we need to sort out

Commentary: Intralesional Melanoma Treatments Are Ready for Prime Time

Commentary: Intralesional Melanoma Treatments Are Ready for Prime Time

A reprint of a commentary from our Cancer Research News site looking at three candidate drugs currently under investigation as intralesional agents for melanoma treatment

Clinical Trials

Keeping pace with Kura

Keeping pace with Kura

Biopharmaceutical company inks Janssen oncology partnership, completes private placement

One and done

One and done

Investigational drug is designed to prevent scarring in dialysis patients

Superior for skin?

Superior for skin?

Boehringer Ingelheim compound outperforms Stelara in head-to-head psoriasis study

Bigger, faster, better connected

Bigger, faster, better connected

The clinical trials community continues to focus on collaborations and new technology to speed results, cut costs

Diagnostics

ConfirmMDx sniffs out prostate cancer

ConfirmMDx sniffs out prostate cancer

Data supporting expanded use of MDxHealth test presented at ASCO Genitourinary Cancers Symposium

GE Healthcare collaboration targets digital pathology

GE Healthcare collaboration targets digital pathology

Effort seeks to give cancer pathology similar computational support as other areas of medicine

Innovating with Inivata

Innovating with Inivata

Biodesix teams with U.K. genomics company to develop NGS blood-based tests for lung cancer

Of a mind for ‘open innovation’

Of a mind for ‘open innovation’

Philips enters collaboration with Janssen on handheld blood test to validate neuropsychiatric disorders

Q&A

Q&A: 'We all came from the sea…'

Q&A: 'We all came from the sea…'

We speak to Mark Currie, CSO and president of R&D for Ironwood Pharmaceutical, about treatments for painful intestinal disorders and more.

Feature

Stem cells: Taking stock in Stockholm

Stem cells: Taking stock in Stockholm

ISSCR will hold 2015 annual meeting in Sweden as part of its ‘great vision’ of global activity

Editor's Focus

21st Century Cures could arrive this century

21st Century Cures could arrive this century

In what seems so far to be something approaching a truly bipartisan effort and possibly a sincere desire for positive change, Congress tackles draft of potential bill that would advance healthcare and health research, as well as boost NIH funding

Preclinical

Eastern efforts

Eastern efforts

Covance to begin drug development partnership with China’s Sihuan Pharmaceutical

Dye light in the limelight

Dye light in the limelight

Okayama University team says light-responsive dye could help combat blindness

Enhancing xenograft use in oncology research

Enhancing xenograft use in oncology research

Novel technology from Taconic and Cellaria collaboration could better generate cells from patient-derived tumors

Stem cells instead of Viagra?

Stem cells instead of Viagra?

Liposuction byproduct could cure erectile dysfunction, study suggests

Vical in- licenses antifungal from Astellas

Vical in- licenses antifungal from Astellas

Preclinical data indicate faster fungicidal activity than marketed drugs and activity against azole-resistant pathogens

Research & Development

Immune dysfunction role in schizophrenia?

Immune dysfunction role in schizophrenia?

UC Davis to establish Conte Center for schizophrenia research to explore novel concept

Constructing ‘beautiful, basic science’

Constructing ‘beautiful, basic science’

Scripps Florida scientists build ribosome assembly process; discover key targets of new anticancer drug candidates

Fatty acids to fight cancer

Fatty acids to fight cancer

WSU researchers show a mechanism by which omega-3 fatty acids inhibit prostate cancer

California dreamin’

California dreamin’

Amyris, Genome Compiler partner to launch first-of-its-kind DNA design and construction software

Ruthigen and Pulmatrix enter into merger agreement

Ruthigen and Pulmatrix enter into merger agreement

Upon the closing of the deal, Pulmatrix will become a wholly owned subsidiary of Ruthigen

Discovery

‘Attracting success’

‘Attracting success’

Evotec, Sanofi launch multifaceted strategic alliance with outsourcing, library sharing

A blueprint for new therapies

A blueprint for new therapies

Blueprint Medicines launches strategic collaboration with Alexion to advance new drug candidates in rare genetic disease

Targeting two with PTP1B

Targeting two with PTP1B

CSHL-Glaxo collaboration looks to combat diabetes and obesity by regulating enzymatic activity of phosphatase PTP1B

From cancer to heart disease

From cancer to heart disease

Bayer and Broad Institute partner to pinpoint genetic roots of cardiovascular disease
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