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March 2025

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A histological section of mouse vaginal tissue infected with Candida albicans after treatment with cell-free supernatant of the strain Limosilactobacillus reuteri 29A.

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Microscopic image of a Gram-stained smear of a vaginal swab at 100x magnification. Stained rods and absence of bacilli indicate bacterial vaginosis. 

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Bacteria from healthy vaginas show promise in protecting women from pathogens, but advancing their development requires more funding and research.

Rebuilding vaginal health with beneficial bacteria

Jessica Ailani wears a white lab coat with a red shirt and smiles.

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Johan Luthman wears a suit and stands as he delivers a presentation.

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A young woman puts her hand on her head with a laptop in front of her. 

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Lundbeck Therapeutics is testing a monoclonal antibody that targets a novel neuropeptide in a Phase 2b clinical trial.&nbsp;

A new migraine medication is on the horizon

A hand holds the Ovaprene contraceptive device between the thumb and pointer finger against a blue background.

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Different contraceptive methods including the injections, contraceptive patch, the pill, an intrauterine device, condom, hormonal ring, diaphragm, and cycle tracking method are shown in pastel colors.

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Sabrina Johnson at Dar&eacute; Bioscience is redefining contraception with Ovaprene, a non-hormonal, monthly option for safe and effective birth control.

A new drug-device combination for non-hormonal contraception

Women's Health

A needle is injecting something into a DNA helix

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A woman holds a newborn baby at the hospital.

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Enzyme replacement therapy has been the mainstay of Pompe disease. New and emerging therapies may provide more options for patients.

Finding new strategies to treat Pompe disease

 A woman injects herself with a GLP-1 pen in the stomach.

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Daniel Drucker and his lab members gather around a lab bench and smile.

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GLP-1 agonists have transformed the treatment of type 2 diabetes and obesity, but they come with side effects. Physicians say the benefits outweigh the risks.

Illuminating the full side effect profile of GLP-1 drugs

Metabolic Disease

A schematic of how the Resistell cantilever bacterial movement detector works is on the left. On the right there are two different readouts: On top is the readout for viable cells, and below is the readout for antibiotics that kill bacteria.

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Multi-colored rod-shaped bacteria sit on top of a cantilever that measures their movement.

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New phenotypic methods can help identify the best antibiotic to treat sepsis, UTIs, and other bacterial infections.

Diagnostics for faster antimicrobial susceptibility testing

Microbiology

A rattlesnake sits curled up on a rock on a ridge in the desert.

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A close encounter with a venomous critter sparked insight for communicating science in times of stress.

Editorial: Of snakes and science communication

Editors Insight

Rameen Beroukhim smiles and wears a blue button-down shirt.

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An image showing a chromosome with the correct number of chromosome 3 side by side next to an addition and deletion of chromosome 3.

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Uri Ben-David and Stefano Santaguida are pictured in their laboratories. 

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: A photo taken from a microscope shows the process of chromosome segregation during cell division.

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Most cancer cells have the wrong number of chromosomes, known as aneuploidy. Scientists are finding ways to target this flaw with new treatments.

&nbsp;Targeting aneuploidy to treat cancer

Cancer

A person wearing a white lab coat types on a laptop with various overlaid enlarged files shown with plus signs on file folders floating over the laptop screen with a clinical lab shown in the background in grey and white tones.

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Thermo Fisher Scientific

Learn how researchers can improve compliance and efficiency with advanced LIMS solutions.

Enhancing bioanalytical studies with centralized data management

Whitepaper

A 3D-rendered digital illustration of a molecular structure floating among red blood cells in a bloodstream environment.

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Takara Bio

By offering a rich source of insights into disease and drugs, metabolite biomarkers are at the forefront of therapeutic exploration.

Explained: How are metabolite biomarkers improving drug discovery and development?

Explainers

Clear cells with round, blue centers are shown against a varied blue background

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Bio-Techne

Researchers can enhance efficiency, yield, and consistency in clonal cell line development with specialized tools.

March 2025 Volume 21, Issue 1

March 2025

In this Issue

Women's Health

Rebuilding vaginal health with beneficial bacteria

A new migraine medication is on the horizon

A new drug-device combination for non-hormonal contraception

Metabolic Disease

Finding new strategies to treat Pompe disease

Illuminating the full side effect profile of GLP-1 drugs

Microbiology

Diagnostics for faster antimicrobial susceptibility testing

Editors Insight

Editorial: Of snakes and science communication

Cancer

Targeting aneuploidy to treat cancer

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Enhancing bioanalytical studies with centralized data management

Explained: How are metabolite biomarkers improving drug discovery and development?

Supercharging cell line development and engineering with automated single cell sorting

March 2025