March 2023 Volume 19, Issue 3

March 2023 Magazine Front Cover

Volume 19, Issue 3 | March 2023

March 2023

In this Issue

Editor's Focus

A dog biting the words A Deadly Bite is drawn over a green background, and orange colored rabies viruses are pictured next to the dog.

Better rabies treatments bite back

Symptomatic rabies has no cure, but recent advances in rabies structural biology and antibody cocktails point to better treatments on the horizon.
A zoomed-in blood vessel from an arm shows a CAR T cell binding to a surface antigen on a cancer cell.

Explained: How does CAR T cell therapy work?

By engineering immune cells to effectively attack cancer cells, researchers established a new paradigm for cancer therapy. 

Disease Pathways

A drawing of a scientist in a white lab coat and glasses stares at a drawing of the gut with colorful microbes within it.

The path to treating Parkinson’s disease begins in the gut

New research is unraveling the connection between the gut microbiome and Parkinson’s disease, revealing potential gut-targeted therapeutic strategies.

Infectious Disease

A brown-haired man sneezes, the droplets are visible in the sun.

Mining mucus for drug inspiration

Therapeutics that mimic or manipulate components of mucus may protect against deadly infections.

Editors Insight

Dots and interconnected lines are superimposed over a crowd of people.

A conference and a COVID-19 close call

As scientific conferences return to in person programming, we still need COVID-19 precautions.

Tools & Techniques

A woman with blond hair exhales on a cold day, forming a cloud of white vapor.

Detecting disease in breath

Researchers are rooting through the concoction of compounds in exhaled breath vapor for metabolic manifestations of COVID-19 and cancer.
Florian Schmidt wears a white and green lab coat while working in a lab.

Bacterial biosensors eavesdrop on the gut

Genetically engineered bacteria could help diagnose or monitor gut diseases.

Cell Therapy

A view of 3D pox viruses through a microscope.

Treating cancer with a dose of the pox

The live virus in the smallpox vaccine boosts the activity of cancer-killing immune cells for hard-to-treat tumors.
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Gold circles with attached purple corkscrew shapes represent gold nanoparticles against a black background.

Driving gene therapy with nonviral vectors 

Learn why nonviral vectors are on the rise in gene therapy development.
A 3D digital illustration of a viral spike protein on a cell surface, surrounded by colorful, floating antibodies in the background

Milestone: Leapfrogging to quantitative, high throughput protein detection and analysis

Researchers continuously push the boundaries of what’s possible with protein analysis tools.
Blue cancer cells attached to a cellular surface against a bright blue background in a 3D rendering of a cancer infection.

Advancing immuno-oncology research with cellular assays

Explore critical insights into immunogenicity and immunotoxicity assays for cancer therapies.
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