March 2023- Volume 19, Issue 3

In this Issue

Editor's Focus

A zoomed-in blood vessel from an arm shows a CAR T cell binding to a surface antigen on a cancer cell.

Explained: How does CAR T cell therapy work?

Explained: How does CAR T cell therapy work?

By engineering immune cells to effectively attack cancer cells, researchers established a new paradigm for cancer therapy. 
A dog biting the words A Deadly Bite is drawn over a green background, and orange colored rabies viruses are pictured next to the dog.

Better rabies treatments bite back

Better rabies treatments bite back

Symptomatic rabies has no cure, but recent advances in rabies structural biology and antibody cocktails point to better treatments on the horizon.

Editors Insight

Dots and interconnected lines are superimposed over a crowd of people.

A conference and a COVID-19 close call

A conference and a COVID-19 close call

As scientific conferences return to in person programming, we still need COVID-19 precautions.

Tools & Techniques

Florian Schmidt wears a white and green lab coat while working in a lab.

Bacterial biosensors eavesdrop on the gut

Bacterial biosensors eavesdrop on the gut

Genetically engineered bacteria could help diagnose or monitor gut diseases.
A woman with blond hair exhales on a cold day, forming a cloud of white vapor.

Detecting disease in breath

Detecting disease in breath

Researchers are rooting through the concoction of compounds in exhaled breath vapor for metabolic manifestations of COVID-19 and cancer.

Infectious Disease

A brown-haired man sneezes, the droplets are visible in the sun.

Mining mucus for drug inspiration

Mining mucus for drug inspiration

Therapeutics that mimic or manipulate components of mucus may protect against deadly infections.

Cell Therapy

A view of 3D pox viruses through a microscope.

Treating cancer with a dose of the pox

Treating cancer with a dose of the pox

The live virus in the smallpox vaccine boosts the activity of cancer-killing immune cells for hard-to-treat tumors.

Disease Pathways

A drawing of a scientist in a white lab coat and glasses stares at a drawing of the gut with colorful microbes within it.

The path to treating Parkinson’s disease begins in the gut

The path to treating Parkinson’s disease begins in the gut

New research is unraveling the connection between the gut microbiome and Parkinson’s disease, revealing potential gut-targeted therapeutic strategies.
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