March 2019 Volume 15, Issue 3
Volume 15, Issue 3 | March 2019
March 2019
In this Issue
Discovery
ALS hope at last?
Small-molecule targets may prevent ALSCopper conflict
Staphyloccocus genes offer potential pathways for overcoming antibacterial resistanceGWAS and new gene answers
Genomic exploration by Chinese researchers uncovers new information regarding genetic schizophrenia riskCDD gains grants
CDD awarded two SBIR grants on digital representation of chemical mixtures, deep learning strategy for drug discoveryStem cells and screening
Ncardia seeks to bring human disease biology earlier into drug discovery and developmentPreclinical
Alternative to animal testing
‘Human-on-a-chip’ models evaluate systemic toxicityPaving the way
Shingles treatment the first of several herpesvirus drug candidates to enter IND-enabling studiesThe data are in on CB 2679d-GT
Catalyst Biosciences announces preclinical data on gene therapy candidate for hemophilia BNatural killer cells promise life
GT Biopharma encouraged by clinical potential of triple-threat TriKE cells in cancerOrion reports positive results for OB-002O
Investigational therapeutic for Colorectal Cancer shows promise in preclinical studyClinical Trials
Immunotherapy before surgery?
Trial indicates that the process shows benefit for gliobastoma patientsMixed results
Companies face both trial roadblocks and progress as they tackle DMDNuzyra fights pneumonia
Drug shown safe and effective in adults with pneumonia and skin infectionsCombating rejection
Kamada’s Phase 2 proof-of-concept trial shows prevention of lung transplant rejection for one yearPositive data for TRC105
TRACON announces results from ongoing Phase 1b/2 trial in hepatocellular carcinomaSpecial Reports
Special Report on Immunology & Autoimmunity: Turn of the coin
Treading the edge between autoimmunity and oncologyCommentary
Out of order: Keep talking
Active discussion regarding diseases and clinical trial progress is important not just for keeping hope alive and boosting awareness, it's also essential in reminding patients and their families that there are others out there who share their strugglesGuest Commentary: A tale of safety and consistency
Drs. Ulrike Herbrand, Christopher Sucato and Alvaro Jorge Amor of Charles River Laboratories discuss the challenges of bringing antibody-drug conjugates to marketFeature
AACR 2019 Show Preview: Integrative cancer science meets individualized care
Over 20,000 attendees will converge on Atlanta this year for the 110th AACR Annual MeetingCancer on the mind
Glioblastoma remains a difficult cancer to treat, but the brain malignancy is seeing increasing attention in R&DFocus Feature: Artificial Intelligence 2.0
Artificial intelligence cannot solve every problem, but it has the potential to break up many bottlenecksDiagnostics
‘Changing the face of genetic diagnostics’
Study shows Bionano’s Saphyr system accurately detects genetic disorder FSHDPrediction precision
New tool said to offer objective prostate cancer assessmentTaking it to the nose to fight lung cancer
Veracyte announces strategic collaboration with Johnson & Johnson for development of nasal swab testFrom mice to man
Elevated hormone flags liver problems related to methylmalonic acidemiaResearch & Development
Dual approach to pancreatic cancer
Roswell Park researchers publish two studies on progress against the diseaseNew options with nitrogen
Rice University researchers describe a novel chemical synthesis approachFrom single-cell to many cells
Researchers use RNA sequencing to investigate spermatogonial stem cells and tackle infertilityHarvard develops kidney organoid
Method for growing kidney organoids under flow enhances their vascularization and maturationA decline for R&D
Research & development returns fall to lowest level in nine yearsContract Services
UK’s Pathios signs CRO Sygnature
Deal focused on development of therapies in autoimmune disease and immuno-oncologyUnder the tongue rather than getting the needle
WuXi STA and BioLingus sign technology and marketing collaboration for sublingual deliverySix.02 Bioservices launches
Company intends to be a ‘new model’ for providing bioservices in protein-based R&DBusiness & Government Policy
Targets acquired
A look at a few recent merger and acquisition deals in the pharma worldOn the cutting edge
A roundup of instrumentation, software and other tools and technology newsNovartis exercises option to license AKCEA-APO(a)-LRx
Phase 3 planning and initiation activities underway; Akcea earns $150-million license feeCommentary: FDA draft guidance on in-vitro DDI studies
How will it impact your drug discovery program?Patent Docs: When is an invention “ready for patenting”?
Federal Circuit panel disputes question in Barry v. MedtronicEditor's Focus
Editor’s focus: Filling the voids
Looking at some of the progress in areas we had been hoping to see more from in the past, including schizophrenia, antibiotics and artificial intelligence
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