March 2015 Volume 11, Issue 3

Volume 11, Issue 3 | March 2015

March 2015

In this Issue

Business & Government Policy

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Roaring back…but more modestly

Pfizer makes first M&A deal since failing to land AstraZeneca, committing to $17 billion for Hospira
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Valeant nabs Dendreon for $400M

Valeant will gain rights to Provenge and certain other assets
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Boosting vaccine vitality

GSK bolsters vaccine division with GlycoVaxyn acquisition
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Patent Docs: Supreme Court revises patent claim construction review standards

Decision comes out of Teva v. Sandoz case and changes standards used for more than a decade
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Two orphans for OncoMed

FDA grants Orphan Drug designations to OncoMed’s tarextumab for pancreatic and small cell lung cancer
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On the cutting edge

A roundup of instrumentation, software and other tools and technology news
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Regulatory roundup

Here are just a few highlights of recent regulatory activities worldwide, from patents approved to designations granted to drugs given the green light for one indication or another
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Deciphering the language of gene regulation

The U.S. National Institutes of Health have awarded grants of more than $28 million total aimed at deciphering the language of how and when genes are turned on and off

Preclinical

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MMRF and Inflection collaborate on new cancer treatment

Current focus is on preclinical testing of innovative dual-mechanism PIM/PI3K inhibitor IBL-202
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Bovine epiphany

Cows inspire TSRI researchers to create therapy that fuses hormones and antibodies
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An answer for glioblastoma?

RES-529 targets TORC1 and TORC2 protein complexes in a dissociative manner to address deadliest brain cancer
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The guiding light

Oregon State’s ‘glowing’ nanotechnology guides cancer surgery, zaps remaining malignant cells
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Industry-academia attack on GM1-gangliosidosis

Trio of Lysogene, UMass Medical School and Auburn University announce collaboration in CNS disease

Feature

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AACR 2015 Show Preview: Bringing cancer discoveries to the patients

AACR brings the world’s largest cancer research conference to Philadelphia

Q&A

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Q&A: Macrocure and the wound-care market

A conversation with Nissim Mashiach, president and CEO of the Israeli company Macrocure Ltd.

Editor's Focus

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Out with the broad and in with the rare

Could a growing interest in rare disease on the part of venture capitalists be to the detriment of novel discoveries by up-and-coming pharmas and biotechs with regard to diseases that affect large populations of patients?

Commentary

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Commentary: Candy Land, opioid addiction and help that’s on its way

Treatment of many types of pain has relied on opioids, which bring their own set of problems. DDNews Managing Editor Lloyd Dunlap explores some of the progress that may mitigate such problems
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Out of order: The vaccine de-bait

DDNews columnist and Features Editor Randall C Willis weighs in on the contentious issue of vaccination and suggests that both sides of the debate may not have much basis for debate in the truest sense of the word

Research & Development

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Taming the tsunami

UCSD, UCSF launch Cancer Cell Mapping Initiative
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New ammo in arms race against antibiotic- resistance

NIH provides grant to Indiana University to build knowledge base about key bacterial cell processes
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Onward and upward with organoids

Culturing techniques for liver and pancreas organoids can mirror disease, cancerous states
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Catalent, Sanofi collaborate on SMARTag, ADCs

Catalent’s tech will help Sanofi evaluate site-selective payload conjugation to enhance ADC PK, efficacy and safety
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Kite Pharma moves forward with Tel Aviv Sourasky Medical Center on chimeric antigen receptors for cancer immunotherapy

Kite Pharma moves forward with Tel Aviv Sourasky Medical Center on chimeric antigen receptor approaches for cancer immunotherapy

Clinical Trials

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A fine showing for migalastat in Fabry

Amicus reports positive Phase 3 data from a pair of studies
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Treatment to target tangles

TauRx demonstrates potential efficacy of tau aggregation inhibitor therapy in Alzheimer’s disease
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Double, double; myeloma in trouble?

Genmab announces preliminary results in Phase 2 study of daratumumab in double refractory multiple myeloma
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‘Catapulting’ forward with MultiStem

Cell Therapy Catapult and £2 million from Innovate UK give some lift to Athersys
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Optimizing trials through mobile health technology

Medidata Solutions Inc. recently announced a strategic collaboration with Garmin International Inc., a unit of Garmin Ltd.

Discovery

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‘Wake-up’ pills for cancer immunotherapy

Curis and Aurigene stretch hands across the sea to jointly discover, develop and eventually commercialize pills to fight cancer
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Trash pickup problem

Peptide could repair damaged mitochondria to regulate Parkinson’s disease
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Investigating immunocytokines

Kymab partners with industry expert for more efficacious, tolerable therapies
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Optibrium integrates NextMove algorithm

StarDrop software suite will incorporate Matsy algorithm, which generates and searches databases of matched molecular series

Diagnostics

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Advancing NSCLC diagnosis and treatment

Biocept and Insight Genetics team up to evaluate expression and mutation in ALK therapeutic target
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Amarantus announces positive Alzheimer’s data

Clinical study of the LymPro Test confirms statistically significant markers for Alzheimer’s
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New study support for Metabolon

Recent study results reinforce the clinical validity of the company’s IGT test
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