March 2015- Volume 11, Issue 3

March 2015

In this Issue

Discovery

Optibrium integrates NextMove algorithm

Optibrium integrates NextMove algorithm

StarDrop software suite will incorporate Matsy algorithm, which generates and searches databases of matched molecular series

‘Wake-up’ pills for cancer immunotherapy

‘Wake-up’ pills for cancer immunotherapy

Curis and Aurigene stretch hands across the sea to jointly discover, develop and eventually commercialize pills to fight cancer

Trash pickup problem

Trash pickup problem

Peptide could repair damaged mitochondria to regulate Parkinson’s disease

Investigating immunocytokines

Investigating immunocytokines

Kymab partners with industry expert for more efficacious, tolerable therapies

Research & Development

Taming the tsunami

Taming the tsunami

UCSD, UCSF launch Cancer Cell Mapping Initiative

New ammo in arms race against antibiotic- resistance

New ammo in arms race against antibiotic- resistance

NIH provides grant to Indiana University to build knowledge base about key bacterial cell processes

Onward and upward with organoids

Onward and upward with organoids

Culturing techniques for liver and pancreas organoids can mirror disease, cancerous states

Catalent, Sanofi collaborate on SMARTag, ADCs

Catalent, Sanofi collaborate on SMARTag, ADCs

Catalent’s tech will help Sanofi evaluate site-selective payload conjugation to enhance ADC PK, efficacy and safety

Preclinical

Industry-academia attack on GM1-gangliosidosis

Industry-academia attack on GM1-gangliosidosis

Trio of Lysogene, UMass Medical School and Auburn University announce collaboration in CNS disease

Bovine epiphany

Bovine epiphany

Cows inspire TSRI researchers to create therapy that fuses hormones and antibodies

An answer for glioblastoma?

An answer for glioblastoma?

RES-529 targets TORC1 and TORC2 protein complexes in a dissociative manner to address deadliest brain cancer

The guiding light

The guiding light

Oregon State’s ‘glowing’ nanotechnology guides cancer surgery, zaps remaining malignant cells

MMRF and Inflection collaborate on new cancer treatment

MMRF and Inflection collaborate on new cancer treatment

Current focus is on preclinical testing of innovative dual-mechanism PIM/PI3K inhibitor IBL-202

Business & Government Policy

Valeant nabs Dendreon for $400M

Valeant nabs Dendreon for $400M

Valeant will gain rights to Provenge and certain other assets

Boosting vaccine vitality

Boosting vaccine vitality

GSK bolsters vaccine division with GlycoVaxyn acquisition

Two orphans for OncoMed

Two orphans for OncoMed

FDA grants Orphan Drug designations to OncoMed’s tarextumab for pancreatic and small cell lung cancer

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

Regulatory roundup

Regulatory roundup

Here are just a few highlights of recent regulatory activities worldwide, from patents approved to designations granted to drugs given the green light for one indication or another

Deciphering the language of gene regulation

Deciphering the language of gene regulation

The U.S. National Institutes of Health have awarded grants of more than $28 million total aimed at deciphering the language of how and when genes are turned on and off

Roaring back…but more modestly

Roaring back…but more modestly

Pfizer makes first M&A deal since failing to land AstraZeneca, committing to $17 billion for Hospira

Clinical Trials

A fine showing for migalastat in Fabry

A fine showing for migalastat in Fabry

Amicus reports positive Phase 3 data from a pair of studies

Treatment to target tangles

Treatment to target tangles

TauRx demonstrates potential efficacy of tau aggregation inhibitor therapy in Alzheimer’s disease

Double, double; myeloma in trouble?

Double, double; myeloma in trouble?

Genmab announces preliminary results in Phase 2 study of daratumumab in double refractory multiple myeloma

‘Catapulting’ forward with MultiStem

‘Catapulting’ forward with MultiStem

Cell Therapy Catapult and £2 million from Innovate UK give some lift to Athersys

Optimizing trials through mobile health technology

Optimizing trials through mobile health technology

Medidata Solutions Inc. recently announced a strategic collaboration with Garmin International Inc., a unit of Garmin Ltd.

Diagnostics

Advancing NSCLC diagnosis and treatment

Advancing NSCLC diagnosis and treatment

Biocept and Insight Genetics team up to evaluate expression and mutation in ALK therapeutic target

Amarantus announces positive Alzheimer’s data

Amarantus announces positive Alzheimer’s data

Clinical study of the LymPro Test confirms statistically significant markers for Alzheimer’s

New study support for Metabolon

New study support for Metabolon

Recent study results reinforce the clinical validity of the company’s IGT test

Commentary

Out of order: The vaccine de-bait

Out of order: The vaccine de-bait

DDNews columnist and Features Editor Randall C Willis weighs in on the contentious issue of vaccination and suggests that both sides of the debate may not have much basis for debate in the truest sense of the word

Commentary: Candy Land, opioid addiction and help that’s on its way

Commentary: Candy Land, opioid addiction and help that’s on its way

Treatment of many types of pain has relied on opioids, which bring their own set of problems. DDNews Managing Editor Lloyd Dunlap explores some of the progress that may mitigate such problems

Feature

Q&A

Q&A: Macrocure and the wound-care market

Q&A: Macrocure and the wound-care market

A conversation with Nissim Mashiach, president and CEO of the Israeli company Macrocure Ltd.

Editor's Focus

Out with the broad and in with the rare

Out with the broad and in with the rare

Could a growing interest in rare disease on the part of venture capitalists be to the detriment of novel discoveries by up-and-coming pharmas and biotechs with regard to diseases that affect large populations of patients?
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