March 2011 Volume 7, Issue 3

Volume 7, Issue 3 | March 2011

March 2011

In this Issue

Global News

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Done deal for Genzyme

sanofi- aventis finalizes agreement to acquire Genzyme for $20.1 billion, up from earlier $18.5 billion offer
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A Valeant effort

Seeking a stronger European presence, Canada’s Valeant Pharmaceuticals acquires Switzerland-based PharmaSwiss for more than $500 million
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Teva reaches into Peru for a purchase

Acquisition of Corporacion Infarmasa will expand Teva's Latin America presence
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Merck takes the Lead in cancer drug development

Merck KgaA, Lead Discovery Centre sign cooperative agreement for anti- cancer compounds discovery
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Taking some hits (in a good way)

Evotec to collaborate with Takeda Cambridge for multitarget hit identification
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Moving to multicenter

Aushon BioSystems and Peking University Cancer Hospital collaborate on diagnostic biomarkers for liver metastases of colorectal cancer
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Companies ink deals in India

QIAGEN, Daiichi Sankyo and Quintiles are latest companies to invest in this emerging market

Diagnostics

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Danaher’s diagnostic deal

Acquisition-hungry company offers to acquire Beckman Coulter for about $6.8 billion
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Off the auction block

Novartis tenders all-cash offer for challenged Genoptix at $25 per share
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Dovetailing into diagnostics

PerkinElmer acquires chemagen Biopolymer-Technologie, the company’s partner for nucleic acid analysis, in effort to better serve the MDx market
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Actient Pharmaceuticals acquires Timm Medical Technologies

Timm’s second-tier erectile dysfunction remedy seen as key to the purchase
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In search of cures for ‘his and hers’ cancers

Nuclea Biotech teams with Boston Medical Center on biomarker development
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Probing cancer cells’ ‘ecosystem’

Pervasis Therapeutics, MIT sign patent license agreement to halt progression of cancer cells

Research & Development

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Rolling the dice with anti-cancer virus

Amgen to spend as much as $1 billion to acquire privately held biotech BioVex based on potential of oncology vaccine
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A marriage of convenience and passion

Ligand's purchase of CyDex ensures new revenue streams, fully funded partnerships and expanding cash-flow positive drug reformulation business
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Pfizer shines in Big Apple

Drugmaker announces that seven of New York City’s top research hospitals join Global Centers For Therapeutic Innovation
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Eyes forward for AMD and more

Alexion acquires Taligen Therapeutics and creates Translational Medicine Group to accelerate development of expanded portfolio
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In the army now

Concert Pharma and Walter Reed Army Institute of Research to evaluate neuroprotective drug compound derived from Concert’s deuterated chemical entity platform

Feature

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Putting an extra “e” in cancer research

American Association for Cancer Research puts Internet to work, with most sessions of AACR 102nd Annual Meeting 2011 to be webcast
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Orlando visitor highlights

Our coverage of just a few things you can do while you’re in the Orlando area for the AACR annual meeting

Commentary

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Using patient- relevant models to enhance cancer drug development

There is a growing need within the pharmaceutical and biotech industries for more “challenging” preclinical modeling for cancer drug development. It is essential to use patient-relevant models to evaluate the cancer medicines of the future in order to ensure that preclinical efficacy assessment is predictive of how the drug is likely to behave in clinical trials with cancer patients.

Patent News

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Stop me if you've heard this before: There’s a Patent Reform Act of 2011

The new legislation is intended to accomplish three primary goals: transition to a first-to-file system; improve patent quality; and provide more certainty in litigation.

Editor's Focus

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ddn readers explain the ‘brain drain’

In response to our February column, readers explain why students in foreign countries choose to advance their education on American soil, only to take their expertise and training abroad later.

Instruments & Informatics

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NuGEN and Caliper partner to eliminate NGS sample prep bottlenecks

Methods are being developed to enable high-throughput, automated extraction, amplification and preparation of difficult and compromised samples for next-generation sequencing
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Catching something good with QTRAP

Collaboration with ARUP Laboratories will use AB SCIEX tech platform to develop new clinical research methods for hormone analysis
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Busy month for IntegenX

Microsample prep company closes $15.6M financing round, acquires GenVault and signs two deals to accelerate commercialization of DNA profiling platform
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Precision—not personalized—medicine

Avantra Biosciences teams with TD2 to speed drug development

Omics & Systems Biology

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Genomics for the win against cancer?

TGen and Genomic Health discover genes affecting cancer drug oxaliplatin, publishing paper calling for more research into mechanisms influencing the drug’s activity
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Setting the standard

European project sets goal of standardizing human genome sequencing
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Putting SMA on the map

Rules-Based Medicine’s MAP platform helps Spinal Muscular Atrophy Foundation reach biomarkers milestone

Government Watch

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Senators urge FDA action on biologics approval

FDA poised to announce decisions on biologic generics’ entrance into market
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Score one for hESC research

A second lawsuit challenging embryonic stem cell research is dismissed by federal appeals court
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Drawing the web tighter

Q&A connects dots between FDA and social media
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A new player in drug research?

The proposed National Center for the Advancement of Translational Sciences would help develop medicines, but is it feasible?
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