June 2025 Volume 21, Issue 2

Drug Discovery News June 2025 Issue

Volume 21, Issue 2 | June 2025

June 2025

In this Issue

Mass Spectrometry

A research technician wearing a green lab gown and head covering, a pair of white gloves and a mask is operating the eNose instrument in a room.

Sniffing out tuberculosis in human breath

Scientists are turning to breath samples as a way to detect tuberculosis economically and conveniently.
A protein ribbon structure is shown in red and blue against a black background.

Mapping proteins to reveal secret drug binding pockets

Chemoproteomic tools are yielding early drug candidates for previously undruggable proteins.
A cartoon image showing superhero figures standing on top of a tall platform with a blue background.

Annihilating PFAS with an AI-designed enzyme

Using artificial intelligence and machine learning, a team of researchers engineered an enzyme to degrade toxic PFAS molecules — and they’re only in high school.

Gene Editing

An older woman massages her sore wrist.

Gene-edited stem cells aim to reverse rheumatoid arthritis

A new approach for gene editing will get its shot in a common and chronic autoimmune disorder.
A 3-D rendering of purple DNA with particles coming off.

Epigenetic editing expands the reach of gene therapy

Rather than permanently cutting DNA, this new kind of gene therapy instead aims to regulate gene expression using epigenetic mechanisms.
A baby girl wears light pink glasses while sitting on the floor.

Curing rare childhood blindness with a special gene therapy

Via a unique regulatory route in the UK, scientists found that a gene therapy restored vision in young kids with a very rare and severe retinal dystrophy.

Antibody Drugs

A graphic with pinkish and purple and blue hues showing a cell infected with HIV.

To fight HIV, antibodies boost the immune system

HIV is incurable because it hides in latently infected cells. Researchers are hoping to change that — and prevent new infections — with the use of antibodies.
IgE antibodies sticking up from a blue sphere.

Ending allergies at the source with a pair of antibody drugs

With new insight into IgE biology, a new, two-pronged strategy for eliminating the pathogenic immune cells that lead to allergies emerges.

Ophthamology

An optometrist gives an eye exam to a senior patient.

An anti-amyloid drug for blindness

Galimedix has recruited people with dry AMD to test the efficacy of their drug, which disrupts the same toxic beta-amyloid oligomers implicated in Alzheimer’s disease.

Editor's Insight

A cartoon image of a woman with a magnifying glass over a book of scientific data.

Toward the publication of every clinical trial

Clinical trials rigorously test treatments to further scientific knowledge and benefit patients. Neither happens if the results are never published.
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Close-up illustration of clustered, irregularly shaped 3D cell structures resembling organoids, displayed in a blue-toned background.
Machine learning-powered image analysis makes it possible to automatically and reliably quantify complex 3D cell structures.
Illustration of a glowing human brain with interconnected neural networks and bright data points, set against a dark, digital background.
Take a closer look at modern techniques that reveal when, where, and how neurons communicate in real time.
Gloved hand holding a petri dish containing red liquid culture medium against a light blue background.
As global regulations shift toward animal-free testing, how can researchers develop more biologically relevant in vitro models to advance drug discovery?
Drug Discovery News June 2025 Issue
Latest IssueVolume 21 • Issue 2 • June 2025

June 2025

June 2025 Issue

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