June 2025 Volume 21, Issue 2

Drug Discovery News June 2025 Issue

Volume 21, Issue 2 | June 2025

June 2025

In this Issue

Mass Spectrometry

A research technician wearing a green lab gown and head covering, a pair of white gloves and a mask is operating the eNose instrument in a room.

The future of tuberculosis diagnosis: using breath to fight disease spread

Researchers are developing new, portable breath analysis tools to diagnose tuberculosis and other diseases, making screenings more accessible in remote areas and beyond.
A protein ribbon structure is shown in red and blue against a black background.

Mapping proteins to reveal secret drug binding pockets

Chemoproteomic tools are yielding early drug candidates for previously undruggable proteins.
A cartoon image showing superhero figures standing on top of a tall platform with a blue background.

Annihilating PFAS with an AI-designed enzyme

Using artificial intelligence and machine learning, a team of researchers engineered an enzyme to degrade toxic PFAS molecules — and they’re only in high school.

Gene Editing

An older woman massages her sore wrist.

Gene-edited stem cells aim to reverse rheumatoid arthritis

A new approach for gene editing will get its shot in a common and chronic autoimmune disorder.
A 3-D rendering of purple DNA with particles coming off.

Epigenetic editing expands the reach of gene therapy

Rather than permanently cutting DNA, this new kind of gene therapy instead aims to regulate gene expression using epigenetic mechanisms.
A baby girl wears light pink glasses while sitting on the floor, symbolizing childhood blindness.

Curing rare childhood blindness with a special gene therapy

Via a unique regulatory route in the UK, scientists found that a gene therapy restored vision in young kids with a very rare and severe retinal dystrophy.

Antibody Drugs

A graphic with pinkish and purple and blue hues showing a cell infected with HIV.

The quest for an HIV cure: How broadly neutralizing antibodies are revolutionizing treatment and prevention

Explore how broadly neutralizing antibodies (bNAbs) are offering a new path to an HIV cure by targeting the latent HIV reservoir and preventing transmission.
IgE antibodies sticking up from a blue sphere.

Ending allergies at the source with a pair of antibody drugs

With new insight into IgE biology, a new, two-pronged strategy for eliminating the pathogenic immune cells that lead to allergies emerges.

Ophthamology

An optometrist gives an eye exam to a senior patient, symbolic of blindness.

New AMD treatments: a race to prevent blindness and vision loss

Learn about the latest advances in age-related macular degeneration (AMD) treatment, including a new drug that targets beta-amyloid to help prevent blindness and vision loss.

Editor's Insight

A cartoon image of a woman with a magnifying glass over a book of scientific data.

Toward the publication of every clinical trial

Clinical trials rigorously test treatments to further scientific knowledge and benefit patients. Neither happens if the results are never published.
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Close-up of a researcher using a stylus to draw or interact with digital molecular structures on a blue scientific interface.
When molecules outgrow the limits of sketches and strings, researchers need a new way to describe and communicate them.
Portrait of Scott Weitze, Vice President of Research and Technical Standards at My Green Lab, beside text that reads “Tell us what you know: Bringing sustainability into scientific research,” with the My Green Lab logo.
Laboratories account for a surprising share of global emissions and plastic waste, making sustainability a priority for modern research.
3D illustration of RNA molecules on a gradient blue background.
With diverse emerging modalities and innovative delivery strategies, RNA therapeutics are tackling complex diseases and unmet medical needs.
Drug Discovery News September 2025 Issue
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