november-2024-front-cover

November 2024

June%202023.pdf

june-2023-front-cover

June 2023

A smaller, rod-shaped bacteria is attached to the outside of a plumper rod-shaped bacteria.

untitled-design-2023-06-06t113108-939

An elderly man lies in a hospital bed in a dimly lit room.

istock-1353357598-1800x900

Daniel Kadouri wears glasses and a white shirt. 

As the antibiotic resistance crisis grows, scientists eye a predatory bacterium as a potential therapeutic.

A living antibiotic: <em>Bdellovibrio</em> bacteria attack and destroy human pathogens

A woman wearing grey holds a pink diagram of the female reproductive system.

58142-1

Vaginal epithelial cells appear to have fuzzy edges in microscopy images thanks to a coating of bacteria. 

3d-cervical-epithelial-cell-model-gray-with-fusobacterium-in-pink-1

Melissa Herbst-Kralovetz wears a white lab coat and blue gloves while pipetting in her lab. 

mhk1

Pink rod-shaped bacteria are attached to the surface of larger gray cervical epithelial cells. 

Caroline Mitchell wears a lab coat and purple gloves while studying bacteria in the lab.

clue-cells

Vaginal dysbiosis has long been a taboo subject, but studying and optimizing the vaginal microbiome could be a game changer for women&rsquo;s health.

The vaginal microbiome is finally getting recognized

Microbiology

Billie Lianoglou smiles while standing outside next to a building with plants nearby.

dr-billie-lianoglou-md-6844-1440x784-2x

Tippi Mackenzie, who is sitting next to a window and wearing a white lab coat, holds a baby dressed in pink. The baby’s mother, Nichelle Obar, sits facing both her baby and Mackenzie.

untitled-design-2023-06-06t163153-181-1

Tippi Mackenzie stands in scrubs and a hair net with other surgeons in a hospital at UCSF.

photocredit-noah-berger-tm-or-2

Alpha thalassemia was once a fatal diagnosis. Now, a clinical trial tests if administering a mother&rsquo;s stem cells in utero may cure kids before they&rsquo;re born.

An in utero stem cell transplant for alpha thalassemia

A headshot of Emily Drabant Conley wearing a blue dress.

federation-bio-e-conley

A team of microbes works via multiple mechanisms to reduce oxalate absorption and kidney stone formation in people with enteric hyperoxaluria. 

federation-bio-l-swem

A headshot of Andreas Grauer wearing a white button-up shirt and black blazer.

federation-bio-andreas-grauer

A fluorescent image shows a black background with a layer of blue blobs at the top, a layer of small multicolored shapes below that, and green intestinal tissue at the bottom. 

untitled-design-2023-06-13t151726-725

A headshot of Lee Swem wearing a blue button-up shirt. 

Seeking complexity and control, researchers developed a drug consisting of 148 bacterial strains &mdash; the largest consortium of its kind to enter clinical trials.

Designing a therapeutic gut microbiome

Clinical Trials

A row of test tubes filled with chemicals of various colors and marked with toxicity symbols. 

58140-1

Research safety programs should address not only immediate hazards, but daily laboratory activities that could cause adverse effects down the road.

Thinking long term for lab safety

A 3D illustration of T cells attacking and killing cancer cells in CAR T cell therapy. 

The pioneering immunology discoveries that birthed CAR T cell therapy and reshaped the battle against cancer.&nbsp;

Science Milestone: Driving T cell therapy

Editor's Focus

A multiplex immunofluorescence image of the mesenchymal colorectal tumor shows irregularly shaped green patches surrounding irregularly shaped patches dotted in pink, light blue, and yellow against a black surface. 

untitled-design-2023-06-19t195942-092-1-1-1

Researchers captured a multicolored image of an aggressive colorectal tumor, revealing a unique biomolecular profile, growth mechanism, and drug target.

Color coding colorectal cancer

A drawing of a person’s abdomen with five pink circles drawn on either side of the person’s belly button. A circle around one of the sets of five pink circles expands into a close up of a single biodiffusion chamber drawn next to a dime to indicate its size.

mark-exley-imvax-chief-scientific-officer

A photograph of Mark Exley wearing a dark suit jacket and a light shirt against a green background.

A biodiffusion chamber with a circular white membrane is shown on the right, and a dime sits next to it on the left, demonstrating that they are of similar size.

coin-1800-x900

A photograph of David Andrews wearing a dark suit jacket and a light shirt.

david-andrews-imvax-co-founder-and-chief-medical-officer

Using tiny chambers that release signals from a patient&rsquo;s own tumor, scientists trigger immune cells to mount a personalized attack against the cancer.

Immunotherapy implants turn brain tumors against themselves

Three variably shaped killer T cells surround a perfectly circular cancer cell in the middle.

58773-ddn-article-image-neoantigens-img-3-elk

A drawing of a woman holding up a magnifying glass to her eye, and inside the magnifying glass are multiple small red cancer cells and a central cancer cell with neoantigens, represented by little lines.

58773-ddn-article-image-neoantigens-elk

Two cancer cells shown in red migrate across a blue surface.

58806

The dream of oncology is precise targeting to destroy cancer cells while avoiding harm to healthy tissues. Identifying the unique proteins of a tumor might finally help reach that goal.

In search of the neoantigen

Immunotherapy

Tracy Criswell wears a white shirt and a black jacket and stands in front of a blue background. 

tracycriswell1-pic

An older woman in a purple shirt smiles as she does a push up. 

istock-1263254168-1800x900

From stem cell-recruiting gels to hormone cycle restoration, Tracy Criswell has big ideas about how to combat age-related decline in muscle regeneration.

Keeping older muscles strong

Three teeth on a piece of gauze with dental instruments next to them.

58141-2

Ana Angelova Volponi sits at a microscope in her laboratory where she studies teeth stem cells.

581412-1

Scientific diagram of the internal anatomy of a tooth and the surrounding gums.

Seven scientists in lab coats standing in a row in Sriram Ravindran’s laboratory.

rgp8169-1

Dental stem cells&rsquo; regenerative powers can help heal more than just teeth.

Stem cells take root

Regenerative Medicine

A scientist wearing gloves handles a pipette over a petri dish and a color-coded microplate in a laboratory setting.

1800x720-istock-only

Sartorius

Learn how fundamental laboratory tools like pipettes and balances support analytical precision.

The unsung tools behind analytical testing success

Application Note

A 3D rendering of motor neurons lit up with blue, purple, orange, and green coloring showing synapses against a black background.

75732-sartorius-improving-als-research-with-pluripotent-stem-cell-derived-models-ppl-kr800x560-istock-only

Discover new advancements in modeling amyotrophic lateral sclerosis.

Improving ALS research with pluripotent stem cell-derived models&nbsp;

Whitepaper

A 3D rendering of round clear cells with multiple red round nodules in each cellular center representing nuclei, suspended in a liquid, clear backdrop. 

75731-sartorius-automating-3d-cell-selection-banners-kr800x560-istock-only-1

Discover precise automated tools for organoid and spheroid handling.&nbsp;

June 2023 Volume 19, Issue 6