June 2018- Volume 14, Issue 6
In this Issue
Contract Services
NanoString partners with CROs on DSP service
NanoString partners with CROs on DSP service
Expanded technology access program is a response to interest from leading biopharma companies and lab service providers
Recipharm teams up with Hadasit
Recipharm teams up with Hadasit
Partnership created with the goal of delivering seamless chemical and clinical services
Rounding the oncology bases
Rounding the oncology bases
CrownBio launches new humanized model, enters strategic partnership with Phanes and presents many posters at AACR 2018
Diagnostics
Expanding the value for Oncomine Dx
Expanding the value for Oncomine Dx
A pair of new deals with Daiichi and Takeda help move Thermo’s technology forward
Exosomes to the rescue?
Exosomes to the rescue?
Minimally invasive test provides early breast cancer detection
G6PD deficiency diagnosis
G6PD deficiency diagnosis
PATH, Mologic work to identify malaria patients at risk of side effects from standard malaria treatment
Amarantus lines up future efforts for LymPro
Amarantus lines up future efforts for LymPro
The company is pursuing a license agreement with Leipzig University, as well as a second clinical study
Preclinical
Relief for devastating skin disease?
Relief for devastating skin disease?
Human placental-derived stem cells boost survival, collagen deposition in mouse models of RDEB
New data on ALG.APV-527 for solid tumors
New data on ALG.APV-527 for solid tumors
Aptevo and Alligator present preclinical data for novel immunotherapy bispecific candidate
Injectable nanos vs. tumors
Injectable nanos vs. tumors
Nanobiotix and Weill Cornell Medicine enter research collaboration
‘Building a better ADC’
‘Building a better ADC’
Sutro Biopharma advances STRO-001 and STRO-002 into the clinic against multiple cancer types
Episodic memory replay
Episodic memory replay
Rats’ replay of events has implications for AD treatments
Research & Development
Triboluminescence at Purdue
Triboluminescence at Purdue
Researchers create triboluminescence instrument to rapidly test whether drugs contain trace crystallinity
Rosalind Franklin has another growth spurt
Rosalind Franklin has another growth spurt
University announces three new disease-based scientific additions to its research park
Illumina ‘tames’ a DRAGEN
Illumina ‘tames’ a DRAGEN
Company gains Edico’s DRAGEN Bio-IT tech for next-generation sequencing in acquisition
Dopamine receptors as cancer biomarker
Dopamine receptors as cancer biomarker
HKBU develops iridium probes that could lead to novel early-detection technology for cancer
Business & Government Policy
Beam launches into base editing
Beam launches into base editing
New company plans to build on CRISPR tech to enable single-letter editing of DNA and RNA
Celsius launches with $65M in financing
Celsius launches with $65M in financing
Company seeks to develop precision therapeutics for people with autoimmune diseases and cancer
On the cutting edge
On the cutting edge
A roundup of instrumentation, software and other tools and technology news
Fate and MSK expand oncology license deal
Fate and MSK expand oncology license deal
Updated agreement to include gene-edited T cell immunotherapies
An agreement at last
An agreement at last
Shire commits to Takeda’s latest acquisition offer of roughly $62 billion
Clinical Trials
Phase 1 phenomenon
Phase 1 phenomenon
First-in-class EZH2 inhibitor demonstrates safety and efficacy
In pursuit of HIV
In pursuit of HIV
Inovio Pennvax-GP HIV vaccine sustained durable memory responses measured one year after the start of the clinical trial
Potential game-changer for OA
Potential game-changer for OA
Flexion Therapeutics explores current and future opportunities for Zilretta, a non-opioid injection for pain
Future looking bright for eClinical solutions
Future looking bright for eClinical solutions
Market to cross $4-billion mark by 2020, driven by unified cloud-based platforms with scalability and modularity
Discovery
XtalPi and Pfizer collaborate on AI
XtalPi and Pfizer collaborate on AI
Aim is to develop artificial intelligence-powered molecular modeling tech for drug discovery
An AI approach to malaria
An AI approach to malaria
Gates Foundation grant to fund work by Recursion and UC San Diego in malaria treatment discovery
It’s molecular!
It’s molecular!
Fujitsu develops molecular simulation technology to effectively create new drug candidates
The next dimension in drug testing
The next dimension in drug testing
Scripps scientists use 3D spheroids to better test cancer drugs’ efficacy
Special Reports
Special Report on Cancer: Aiming for avatars
Special Report on Cancer: Aiming for avatars
Oncologists seek clarity via patient-derived models
Editor's Focus
Editor’s focus: Medicines going digital?
Editor’s focus: Medicines going digital?
Before we start getting too comfortable using terms like "digital therapeutics" or "digiceuticals" maybe we should establish exactly what they are
Commentary
Guest commentary: Improving clinical trial design in acute pain
Guest commentary: Improving clinical trial design in acute pain
Biopharma companies must consider a great deal when designing a trial that will enable a pain medication to show significant treatment effect compared to placebo
Rats and me
Rats and me
There remains a place for animal testing with regard to human therapeutics, even as the space grows to use non-animal alternatives more
Feature
Spotlight on Oncology: Pushing the tumor boundaries
Spotlight on Oncology: Pushing the tumor boundaries
A roundup of very recent novel research in the field of oncology
