June 2016- Volume 12, Issue 6

June 2016

In this Issue

Diagnostics

Genestack and CMDL enter collaboration

Genestack and CMDL enter collaboration

Partners to create informatics platform for use in clinical care

A repeat partnership

A repeat partnership

Rheonix, NYUCD to collaborate for rapid Zika virus diagnostic

Sunquest acquires GeneInsight

Sunquest acquires GeneInsight

Decision is intended to enhance Sunquest’s precision medicine capabilities and advance Sunquest’s clinical genetics IT platform

CombiMatrix unveils CombiPGD

CombiMatrix unveils CombiPGD

Genetic test helps to identify genetic defects in embryos

Business & Government Policy

Thermo Fisher Scientific to acquire FEI

Thermo Fisher Scientific to acquire FEI

$4.2 billion buys Thermo an even stronger mass spectrometry leadership position with complementary tech

Keeping an eye on Eylea

Keeping an eye on Eylea

Regeneron’s ophthalmology drug posts strong Q1 earnings

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

Noodling around the NIH

Noodling around the NIH

A quick look at news coming out of or relating to the National Institutes of Health

Research & Development

Companies seek a boost to ALS research

Companies seek a boost to ALS research

Work may eventually extend to other neurodegenerative diseases associated with superoxide dismutase 1 misfolding

Aiming Probody compounds at CD71

Aiming Probody compounds at CD71

Collaboration between AbbVie and CytomX will develop drug conjugates to deliver cytotoxic payloads to tumor cells

Homology platform ‘leapfrogs’ onto the scene

Homology platform ‘leapfrogs’ onto the scene

Financing efforts help launch next-generation genetics company with $43.5 million

Open-access opportunities

Open-access opportunities

CAMD joins GAAIN initiative to share Alzheimer's clinical trial data

Preclinical

Vaccine verification

Vaccine verification

Preclinical results support Abeta vaccine for treating Down syndrome cognitive deficits

Tumor tackler

Tumor tackler

Preclinical IMO-2125 data demonstrate enhanced systemic antitumor activity

A trio of promising studies

A trio of promising studies

Enhanced immune responses, antitumor activity bode well for Corvus' CPI-444

Putting the CAR T before the horse

Putting the CAR T before the horse

Endocyte and Purdue present promising preclinical data for SMDC technology, CAR T cell therapy

Contract Services

IMS Health and Quintiles to merge

IMS Health and Quintiles to merge

Companies say combined entity will be industry-leading information and technology-enabled healthcare service provider

Going for leadership status

Going for leadership status

Swedish CDMO Recipharm acquires businesses from India-based Kemwell

Cloud control

Cloud control

PAREXEL and EMC collaborate on cloud-based document and regulatory information management services

Discovery

Partners to advance early-stage discovery

Partners to advance early-stage discovery

FEI teams with five pharmas, MRC and University of Cambridge to form Cryo-EM Research Consortium

Unlocking memory’s mysteries

Unlocking memory’s mysteries

TSRI study identifies common fruit fly gene with implications in strengthening memory

Exploring synergy in immunology

Exploring synergy in immunology

Aduro and UC Berkeley seek to accelerate treatment and prevention of cancer, infectious and autoimmune diseases

A homegrown partnership

A homegrown partnership

U.K. companies Kymab and Heptares partner on GPCRs against cancer

Clinical Trials

EMA looks to improve safety of first-in-human trials

EMA looks to improve safety of first-in-human trials

Reflection on changes to best practices begins in wake of French clinical trial tragedy

Working toward a fibroid solution

Working toward a fibroid solution

Repros Therapeutics’ Proellex appears to reduce bleeding in women with uterine fibroids

A status update on SRSE efforts

A status update on SRSE efforts

SAGE-457 shows efficacy in treating severe seizure disorder and advances to Phase 3 trial

End to end for imaging and workflows

End to end for imaging and workflows

Medidata’s acquisition of Intelemage seeks in part to improve data and image handling for clinical trials

Accelerating oncology trials

Accelerating oncology trials

M2Gen partners with pharmas and ORIEN to speed targeted trials for advanced-stage cancers

Editor's Focus

The diseases are rare, corporate maneuvers are not; balance must be key

The diseases are rare, corporate maneuvers are not; balance must be key

Rare diseases, like M&As and creative collaboration deals before them, present opportunities for pharmas and biotechs to boost their bottom lines, but there is a risk of tunnel vision (and plenty of precedent for it as well) of which we must remain wary

Commentary

Thin really does matter after all

Thin really does matter after all

Some might argue that saying 'thin is in' with regard to humans is a matter of size discrimination, but in science and technology, thin can make all the difference in the world for better results

Guest Commentary: Back to cancer’s drawing board

Guest Commentary: Back to cancer’s drawing board

Decades after the precision medicine revolution began, it is worth assessing whether the evidence still supports genomics as the primary pillar upon which to understand cancer and make treatment decisions

Feature

Commentary: Identification of durable, assessable biomarker signatures for parasite-induced cholangiocarcinoma

Commentary: Identification of durable, assessable biomarker signatures for parasite-induced cholangiocarcinoma

Biomarkers that are present in body fluids have the potential to form the basis of affordable diagnostic tests to detect diseases in their earliest stages and monitor disease progression (and allow vital treatment where early intervention is crucial or diagnosis currently difficult), and neglected tropical diseases are provided here as an example.

Special Reports

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