July 2019 Volume 15, Issue 7

Volume 15, Issue 7 | July 2019

July 2019

In this Issue

Research & Development

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Meet the Mini-Brain

AxoSim licenses revolutionary Mini-Brain technology from Johns Hopkins
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Amicus-Penn collaboration gains new life

Partners have expanded their agreement to include new indications and new research programs
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A banner day for modeling

Q2 saw encouraging advances in disease modeling options
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Collaboration center

Platform will help to characterize biotherapeutic products
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A need for diversity

Study finds that over 75 percent of genomic data is of European origin

Discovery

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Working to ‘develop tomorrow’s drugs’

GSK, University of California to establish new lab for genetic and CRISPR research
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Gilead, Goldfinch take aim at kidney disease

All told, the total deal value could reach over $2B if all milestones are met
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Big agreements for Atomwise

Atomwise announces deals with Eli Lilly and Enamine
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A better picture of how antibiotics kill

Machine learning reveals metabolic pathways disrupted by the drugs
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Accelerating antibiotics

Polyphor and the University of Zurich examine new class of drugs inhibiting the LPS transport pathway

Clinical Trials

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A new network

National Kidney Foundation introduces its plan for an expansive kidney disease registry
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If at first you don't succeed...

Despite setback with IFX-1, InflaRx continues testing
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Imago unveils IMG-7289

Safety and efficacy data informs expansion of study into Phase 2b
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Design in the cloud

Exploristics announces launch of KerusCloud 2.0
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A faster track for flu vaccine

Novavax confirms accelerated approval pathway available for licensure of NanoFlu

Special Reports

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Special Report on Drug Screening: Phenotypic finery

Microscopy meets the molecular in the search for phenotypic impacts in drug screening

Feature

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Focus Feature on Cancer Research News: Hitting the target

It’s never just been about killing or removing tumors; it’s about aiming at them accurately

Commentary

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Guest Commentary: ACT clinical trials--The long road

As excitement and investment related to adoptive cell transfer products increases, there are concerns and issues that need to be addressed in terms of long-term follow-up trials
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Out of order: Inverted focus?

Our microbiomes might adversely influence some therapeutics that we take, but does that mean that we should be altering the microbiome to compensate?

Editor's Focus

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Editor’s focus: Off-target effect from inactives?

More information about adverse effects of so-called 'inactive' ingredients could be useful, but it also could just be a ton more information that we can't do much with once we have it

Preclinical

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Stem-ulating research

Two branches of stem cell research discover the impact on both diabetes and cardiac damage
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Potential to treat Pompe disease

Findings validate gene therapy approach
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Immunotherapies vs. infections

Breakthrough research identifies a potential vaccine against deadly fungus
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The rodents shall remain

Rats and mice expected to continue as most lucrative species for animal models

Business & Government Policy

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AbbVie makes $63B play for Allergan

Proposed acquisition is said to be a ‘tranformative’ move for both companies
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On the cutting edge

A roundup of instrumentation, software and other tools and technology news
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Advancing biologics

FDA takes new step to help advance the transition of certain biological products
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New mass spec for Thermo

Thermo Fisher Scientific acquires Slovakian mass spec software firm HighChem
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Patent Docs: BIO International Convention wrap-up

Kevin Noonan, a partner with the law firm McDonnell Boehnen Hulbert & Berghoff LLP and founding author of the Patent Docs weblog, recaps the highlights of the latest annual BIO meeting

Diagnostics

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Double duty for ingestible technology

Micro-bio-electronic device might be able to diagnose and treat GI problems
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A stool test for cirrhosis

UC San Diego researchers analyze stool microbes to diagnose liver disease
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ADDF commits $50M to early AD detection

Alzheimer’s Drug Discovery Foundation aims to fast-track digital tools for the disease
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‘Liquid’ assets

A look at a recent FDA decision and analyst forecasts in the field of liquid biopsy

Contract Services

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Charles River cultivates change

Charles River constructs new collaborative science partnerships
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Aldevron adds space

Biologics manufacturer expands and names new business heads
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Marking an anniversary

BioAscent records successful first year as fully integrated discovery services CRO
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