July 2018- Volume 14, Issue 7

In this Issue

Business & Government Policy

Patent Docs: BIO International Convention Wrap-up

Patent Docs: BIO International Convention Wrap-up

Kevin Noonan gives us a quick recap of what went on at the meeting and what you might want to know about

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

7 Hills launches with $2M SBIR grant

7 Hills launches with $2M SBIR grant

An additional $4 million in seed capital will help new company pursue novel cancer therapeutics

iPSC interest

iPSC interest

FCDI licenses technology from UC Irvine to develop iPSC-derived microglia for neurological disease models

Strengthening its immuno-oncology portfolio

Strengthening its immuno-oncology portfolio

Apeiron signs licensing deal for new checkpoint inhibitor with the Medical University of Vienna and IMB

Preclinical

Signal stopper

Signal stopper

Molecule blocks neuropathic pain without negative side effects

Do animal studies predict human safety?

Do animal studies predict human safety?

Study of FDA and EMA reports analyzes predictivity of animal-human relationship in relation to patient safety

MANF protein may ease TBI symptoms

MANF protein may ease TBI symptoms

MANF Therapeutics restarts IND-enabling work in light of new results

Research & Development

Bacterial DNA uptake has IU scientists hooked

Bacterial DNA uptake has IU scientists hooked

The first direct observation of the DNA uptake process could help advance efforts against drug-resistant bacteria

Underuse of specimens concerns biobanks

Underuse of specimens concerns biobanks

Economic sustainability also challenges biobanks, even as outside researchers struggle to find the specimens they need

NETs of neutrophils

NETs of neutrophils

University of Bristol researcher investigates immune cell defense against microbes

Veterinary drug could curb malaria and Zika outbreaks

Veterinary drug could curb malaria and Zika outbreaks

Calibr researchers look at a class of drugs called isoxazolines with an eye toward human use

Cracking the code

Cracking the code

Scripps uncovers new transcription factor combos to reprogram skin cells into different neurons

Discovery

Capitalizing on connection

Capitalizing on connection

BioAscent and XenoGesis combine core capabilities

A meeting of the minds

A meeting of the minds

Insilico and WuXi AppTec use AI in drug discovery

Infections under fire

Infections under fire

AiCuris, Max Planck Institute look to natural products for new weapons against viral, bacterial infections

Moss polysaccharide discovery likened to beta glucen

Moss polysaccharide discovery likened to beta glucen

Compound discovered in moss could have potential for health and medical uses

Sybodies on the scene

Sybodies on the scene

leadXpro and University of Zurich collaboration to generate membrane protein target-directed sybodies

Feature

Immuno-oncology roundup

Immuno-oncology roundup

A roundup of recent research and deal-making news in the field of immuno-oncology, as well as a bonus guest commentary from Novella Clinical

IO Summit 2018 Show Preview: Informing immuno-oncology

IO Summit 2018 Show Preview: Informing immuno-oncology

Be Boston-bound for erudition in the newest science, technology and techniques in cancer immunotherapy

Special focus on neuroscience: Neurodegenerative disease

Special focus on neuroscience: Neurodegenerative disease

We take a look at some of the latest research on neurodegeneration, beginning with Alzheimer's disease but covering Parkinson's disease and multiple sclerosis as well

Commentary

Out of order: Right not to try?

Out of order: Right not to try?

Right-to-Try sounds good, and it may even be good in some ways, but we need to consider the implications for impacting therapeutic research negatively

Guest Commentary: Improving results after hematopoietic stem cell transplantation

Guest Commentary: Improving results after hematopoietic stem cell transplantation

HSCT represents a revolution in the treatment of many maladies, but it is an incomplete revolution at present

Contract Services

Grant awarded for continuous modular manufacturing

Grant awarded for continuous modular manufacturing

Arcinova looks to be a leader in defining continuous manufacturing tech supporting new chemical entities development, scale up and manufacture

Creating open-tech standards for better trial collaboration and execution

Creating open-tech standards for better trial collaboration and execution

Advanced Clinical joins Align Clinical CRO, a group dedicated to making it easier for sponsors and CROs to work together on trials

Diagnostics

Proper prediction in prostate cancer

Proper prediction in prostate cancer

New studies indicate a valid, predictive biomarker for mCRPC

The nose knows

The nose knows

Mount Sinai researchers use nasal brush test to diagnose asthma

Ingestible ‘bacteria on a chip’

Ingestible ‘bacteria on a chip’

Ultra-low-power sensors carrying genetically engineered bacteria can diagnose GI disorders

The war against resistance advances

The war against resistance advances

U.K. and FIND team up to combat global threat of antimicrobial resistance

Clinical Trials

New investment in treating superbugs

New investment in treating superbugs

Melinta Therapeutics seeks to move investigational pyrrolocytosine compounds into clinical stage

The new migraine muffler(s)

The new migraine muffler(s)

Allergan’s oral CGRP receptor antagonist demonstrates robust efficacy and safety in episodic migraine prevention

REVERSE-ing vision loss

REVERSE-ing vision loss

GenSight’s GS010 improves vision in Phase 3 trial of patients with rare genetic disease

Cannabis vs. Lennox-Gastaut syndrome

Cannabis vs. Lennox-Gastaut syndrome

Positive results published in NEJM for clinical trial of Epidiolex in LGS

Editor's Focus

Editor’s focus: Cancer should not be a ‘popularity contest’

Editor’s focus: Cancer should not be a ‘popularity contest’

What important areas of cancer research do we leave behind when we forge ahead so strongly with the most media-obsessed and most lovingly funded ones?
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