July 2018 Volume 14, Issue 7
Volume 14, Issue 7 | July 2018
July 2018
In this Issue
Discovery
Sybodies on the scene
leadXpro and University of Zurich collaboration to generate membrane protein target-directed sybodiesCapitalizing on connection
BioAscent and XenoGesis combine core capabilitiesA meeting of the minds
Insilico and WuXi AppTec use AI in drug discoveryInfections under fire
AiCuris, Max Planck Institute look to natural products for new weapons against viral, bacterial infectionsMoss polysaccharide discovery likened to beta glucen
Compound discovered in moss could have potential for health and medical usesResearch & Development
Cracking the code
Scripps uncovers new transcription factor combos to reprogram skin cells into different neuronsBacterial DNA uptake has IU scientists hooked
The first direct observation of the DNA uptake process could help advance efforts against drug-resistant bacteriaUnderuse of specimens concerns biobanks
Economic sustainability also challenges biobanks, even as outside researchers struggle to find the specimens they needNETs of neutrophils
University of Bristol researcher investigates immune cell defense against microbesVeterinary drug could curb malaria and Zika outbreaks
Calibr researchers look at a class of drugs called isoxazolines with an eye toward human useDiagnostics
The war against resistance advances
U.K. and FIND team up to combat global threat of antimicrobial resistanceProper prediction in prostate cancer
New studies indicate a valid, predictive biomarker for mCRPCThe nose knows
Mount Sinai researchers use nasal brush test to diagnose asthmaIngestible ‘bacteria on a chip’
Ultra-low-power sensors carrying genetically engineered bacteria can diagnose GI disordersFeature
Special focus on neuroscience: Neurodegenerative disease
We take a look at some of the latest research on neurodegeneration, beginning with Alzheimer's disease but covering Parkinson's disease and multiple sclerosis as wellIO Summit 2018 Show Preview: Informing immuno-oncology
Be Boston-bound for erudition in the newest science, technology and techniques in cancer immunotherapyImmuno-oncology roundup
A roundup of recent research and deal-making news in the field of immuno-oncology, as well as a bonus guest commentary from Novella ClinicalEditor's Focus
Editor’s focus: Cancer should not be a ‘popularity contest’
What important areas of cancer research do we leave behind when we forge ahead so strongly with the most media-obsessed and most lovingly funded ones?Commentary
Out of order: Right not to try?
Right-to-Try sounds good, and it may even be good in some ways, but we need to consider the implications for impacting therapeutic research negativelyGuest Commentary: Improving results after hematopoietic stem cell transplantation
HSCT represents a revolution in the treatment of many maladies, but it is an incomplete revolution at presentContract Services
Grant awarded for continuous modular manufacturing
Arcinova looks to be a leader in defining continuous manufacturing tech supporting new chemical entities development, scale up and manufactureCreating open-tech standards for better trial collaboration and execution
Advanced Clinical joins Align Clinical CRO, a group dedicated to making it easier for sponsors and CROs to work together on trialsClinical Trials
New investment in treating superbugs
Melinta Therapeutics seeks to move investigational pyrrolocytosine compounds into clinical stageThe new migraine muffler(s)
Allergan’s oral CGRP receptor antagonist demonstrates robust efficacy and safety in episodic migraine preventionREVERSE-ing vision loss
GenSight’s GS010 improves vision in Phase 3 trial of patients with rare genetic diseaseCannabis vs. Lennox-Gastaut syndrome
Positive results published in NEJM for clinical trial of Epidiolex in LGSBusiness & Government Policy
iPSC interest
FCDI licenses technology from UC Irvine to develop iPSC-derived microglia for neurological disease modelsStrengthening its immuno-oncology portfolio
Apeiron signs licensing deal for new checkpoint inhibitor with the Medical University of Vienna and IMBOn the cutting edge
A roundup of instrumentation, software and other tools and technology news7 Hills launches with $2M SBIR grant
An additional $4 million in seed capital will help new company pursue novel cancer therapeuticsPatent Docs: BIO International Convention Wrap-up
Kevin Noonan gives us a quick recap of what went on at the meeting and what you might want to know aboutPreclinical
Signal stopper
Molecule blocks neuropathic pain without negative side effectsDo animal studies predict human safety?
Study of FDA and EMA reports analyzes predictivity of animal-human relationship in relation to patient safetyMANF protein may ease TBI symptoms
MANF Therapeutics restarts IND-enabling work in light of new resultsA unique mechanism of action for delivering IL-10
APVO210 holds promise in the treatment of autoimmune diseases
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