July 2015 Volume 11, Issue 7
Volume 11, Issue 7 | July 2015
July 2015
In this Issue
Q&A
Q&A: Keeping it small (molecule) and focused on cancer
DDNews talks to Timothy Clackson, Ph.D., president of research and development at ARIAD, about the company's drug discovery programs and structure-based drug design to create molecules that overcome resistance to existing treatmentsEditor's Focus
M&As: Let’s serve ‘em up rare and juicy
The rare disease/orphan disease space has become quite the hot commodity for many pharmas as they look to merger and acquisition deals; but are some of them overreaching and are we getting to a tipping point soon?Commentary
Out of Order: Picture this, will you?
Pharmas and biotechs of all sizes would benefit greatly by a small investment of time and money into cameras and making photos of their executives and operations easily accessibleCommentary: The changing face of nonclinical development
CROs are adapting service offerings to provide customers with increased understanding of drug mechanism of action on safety studiesSpecial Reports
Cell Biology Special Report: Feeling out phenotypes
Using omics approaches, researchers digitize the analog world of cell biologyResearch & Development
A CRISPR approach
NHGRI scientists combine CRISPR/Cas9 and zebrafish for high-throughput, multiplexed gene editingAnti- amyloid answer?
Human antibody has potential for treating Alzheimer’s disease‘Homing beacon’ for pathogens
UCSD research leads to tool that might help researchers to track and attack pathogenic bacteriaA new player in New Jersey
ATCC and ILSE announce establishment of translational microbiology centerDiagnostics
New data support continued onapristone and CDx development
Arno presents data from three abstracts during ASCO’s ‘Gynecologic Cancer’ and ‘Genitourinary (Prostate) Cancer’ poster sessionsWorking all the angles
Parsortix technology from ANGLE shows major promise in cancer detection and diagnosisPaired against pancreatic cancer
Halozyme and Ventana to jointly develop PEGPH20 to fight metastatic pancreatic cancerOut of the lab, into the hospital
Study examines potential of whole-genome sequencing in standard patient careFluxion, Swift team up on NGS workflow for liquid biopsies
Fluxion Biosciences Inc. and Swift Biosciences Inc. announced a new workflow for oncology clinical research designed to detect somatic mutations from a routine blood drawClinical Trials
Living longer with Roche
Results of a trio of clinical trials of Roche therapeutics in various cancers show patients living longer without disease worseningGetting personal
New study suggests clinical trial results may be significantly affected by personal behaviorPromise for AML?
Actinium presents positive initial results from Phase 1/2 trial at 2015 ASCO meetingStem and spine
StemCells’ spinal cord injury Phase 1/2 study yields ‘groundbreaking’ resultsSweet results for imeglimin
Poxel’s imeglimin shows potential as type 2 diabetes treatment in clinical trialNCI-MATCH to use Thermo NGS technology
Trial to sequence thousands of tumor samples using Ion Torrent targeted sequencing technologyBusiness & Government Policy
Broadening its immuno-oncology options
Cellular Biomedicine Group to acquire vaccine for use in lung cancer clinical trialShire rumored to be shopping for Swiss biotech
U.K.-based company’s reported $18.9- billion offer sends Actelion shares soaring, but apparently not its heartPatent Docs: BIO International Convention wrap-up
The Biotechnology Industry Organization, or BIO, held its 2015 BIO International Convention in Philadelphia June 15-18, with more than 15,000 attendees and in excess of 1,700 exhibitors in the exhibit hallOn the cutting edge
A roundup of instrumentation, software and other tools and technology newsDanaher to acquire Pall for $13.8 billion
Move represents company’s progress away from manufacturing and toward healthcare instrumentationPreclinical
Relying on Reolysin
Oncolytics sees promising results from reovirus compound in combination therapy regimensArno explores new class of antimicrobial drugs
Work includes possible biodefense and public health applications for compound known as AR-12Fighting pain fivefold better?
Studies indicate boronicaine may provide pain relief five times longer than lidocaine and be an alternative type of anestheticMaking migraine less of a pain
Researchers establish that vagus nerve stimulation is effective in suppressing cortical spreading depression, a trigger for migraineDiscovery
A boost for immunology
Lilly and Sanford Burnham Prebys collaborate to discover, develop therapies for lupus, Sjögren’s and moreTrucking along with CAR T
Juno keeps busy with partnerships, purchases supporting its T cell technologyPartner pairing
Adimab announces antibody collaborations with Celgene and KiteOld is new again
Decades-old antibiotic could be the key to new melanoma treatmentTSRI study points to unexplored realm of protein biology and potential new drug targets
TSRI study points to unexplored realm of protein biology and potential new drug targets
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Discovering deeper insights into malaria research
Malaria continues to drive urgent research worldwide, with new therapies and tools emerging to combat the parasite’s complex lifecycle and global burden.
Accelerating RNA therapeutic testing with liver microphysiological platforms
Researchers can now study oligonucleotide delivery and efficacy in a system that models a real human liver.
Shining light on the subcellular proteome
Discover how innovative proteomics tools help researchers peer into once inaccessible organelles, allowing for new targets for drug discovery and development.
