July 2015- Volume 11, Issue 7

July 2015

In this Issue

Research & Development

‘Homing beacon’ for pathogens

‘Homing beacon’ for pathogens

UCSD research leads to tool that might help researchers to track and attack pathogenic bacteria

A new player in New Jersey

A new player in New Jersey

ATCC and ILSE announce establishment of translational microbiology center

Anti- amyloid answer?

Anti- amyloid answer?

Human antibody has potential for treating Alzheimer’s disease

A CRISPR approach

A CRISPR approach

NHGRI scientists combine CRISPR/Cas9 and zebrafish for high-throughput, multiplexed gene editing

Preclinical

Relying on Reolysin

Relying on Reolysin

Oncolytics sees promising results from reovirus compound in combination therapy regimens

Arno explores new class of antimicrobial drugs

Arno explores new class of antimicrobial drugs

Work includes possible biodefense and public health applications for compound known as AR-12

Fighting pain fivefold better?

Fighting pain fivefold better?

Studies indicate boronicaine may provide pain relief five times longer than lidocaine and be an alternative type of anesthetic

Making migraine less of a pain

Making migraine less of a pain

Researchers establish that vagus nerve stimulation is effective in suppressing cortical spreading depression, a trigger for migraine

Discovery

A boost for immunology

A boost for immunology

Lilly and Sanford Burnham Prebys collaborate to discover, develop therapies for lupus, Sjögren’s and more

Trucking along with CAR T

Trucking along with CAR T

Juno keeps busy with partnerships, purchases supporting its T cell technology

Partner pairing

Partner pairing

Adimab announces antibody collaborations with Celgene and Kite

Old is new again

Old is new again

Decades-old antibiotic could be the key to new melanoma treatment

Clinical Trials

Getting personal

Getting personal

New study suggests clinical trial results may be significantly affected by personal behavior

Promise for AML?

Promise for AML?

Actinium presents positive initial results from Phase 1/2 trial at 2015 ASCO meeting

Stem and spine

Stem and spine

StemCells’ spinal cord injury Phase 1/2 study yields ‘groundbreaking’ results

Sweet results for imeglimin

Sweet results for imeglimin

Poxel’s imeglimin shows potential as type 2 diabetes treatment in clinical trial

NCI-MATCH to use Thermo NGS technology

NCI-MATCH to use Thermo NGS technology

Trial to sequence thousands of tumor samples using Ion Torrent targeted sequencing technology

Living longer with Roche

Living longer with Roche

Results of a trio of clinical trials of Roche therapeutics in various cancers show patients living longer without disease worsening

Diagnostics

Fluxion, Swift team up on NGS workflow for liquid biopsies

Fluxion, Swift team up on NGS workflow for liquid biopsies

Fluxion Biosciences Inc. and Swift Biosciences Inc. announced a new workflow for oncology clinical research designed to detect somatic mutations from a routine blood draw

Working all the angles

Working all the angles

Parsortix technology from ANGLE shows major promise in cancer detection and diagnosis

Paired against pancreatic cancer

Paired against pancreatic cancer

Halozyme and Ventana to jointly develop PEGPH20 to fight metastatic pancreatic cancer

Out of the lab, into the hospital

Out of the lab, into the hospital

Study examines potential of whole-genome sequencing in standard patient care

New data support continued onapristone and CDx development

New data support continued onapristone and CDx development

Arno presents data from three abstracts during ASCO’s ‘Gynecologic Cancer’ and ‘Genitourinary (Prostate) Cancer’ poster sessions

Business & Government Policy

Broadening its immuno-oncology options

Broadening its immuno-oncology options

Cellular Biomedicine Group to acquire vaccine for use in lung cancer clinical trial

Shire rumored to be shopping for Swiss biotech

Shire rumored to be shopping for Swiss biotech

U.K.-based company’s reported $18.9- billion offer sends Actelion shares soaring, but apparently not its heart

Patent Docs: BIO International Convention wrap-up

Patent Docs: BIO International Convention wrap-up

The Biotechnology Industry Organization, or BIO, held its 2015 BIO International Convention in Philadelphia June 15-18, with more than 15,000 attendees and in excess of 1,700 exhibitors in the exhibit hall

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

Danaher to acquire Pall for $13.8 billion

Danaher to acquire Pall for $13.8 billion

Move represents company’s progress away from manufacturing and toward healthcare instrumentation

Editor's Focus

M&As: Let’s serve ‘em up rare and juicy

M&As: Let’s serve ‘em up rare and juicy

The rare disease/orphan disease space has become quite the hot commodity for many pharmas as they look to merger and acquisition deals; but are some of them overreaching and are we getting to a tipping point soon?

Commentary

Out of Order: Picture this, will you?

Out of Order: Picture this, will you?

Pharmas and biotechs of all sizes would benefit greatly by a small investment of time and money into cameras and making photos of their executives and operations easily accessible

Commentary: The changing face of nonclinical development

Commentary: The changing face of nonclinical development

CROs are adapting service offerings to provide customers with increased understanding of drug mechanism of action on safety studies

Special Reports

Cell Biology Special Report: Feeling out phenotypes

Cell Biology Special Report: Feeling out phenotypes

Using omics approaches, researchers digitize the analog world of cell biology

Q&A

Q&A: Keeping it small (molecule) and focused on cancer

Q&A: Keeping it small (molecule) and focused on cancer

DDNews talks to Timothy Clackson, Ph.D., president of research and development at ARIAD, about the company's drug discovery programs and structure-based drug design to create molecules that overcome resistance to existing treatments
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