July 2015- Volume 11, Issue 7
July 2015
In this Issue
Clinical Trials
Sweet results for imeglimin
Sweet results for imeglimin
Poxel’s imeglimin shows potential as type 2 diabetes treatment in clinical trial
NCI-MATCH to use Thermo NGS technology
NCI-MATCH to use Thermo NGS technology
Trial to sequence thousands of tumor samples using Ion Torrent targeted sequencing technology
Getting personal
Getting personal
New study suggests clinical trial results may be significantly affected by personal behavior
Promise for AML?
Promise for AML?
Actinium presents positive initial results from Phase 1/2 trial at 2015 ASCO meeting
Stem and spine
Stem and spine
StemCells’ spinal cord injury Phase 1/2 study yields ‘groundbreaking’ results
Living longer with Roche
Living longer with Roche
Results of a trio of clinical trials of Roche therapeutics in various cancers show patients living longer without disease worsening
Research & Development
Anti- amyloid answer?
Anti- amyloid answer?
Human antibody has potential for treating Alzheimer’s disease
‘Homing beacon’ for pathogens
‘Homing beacon’ for pathogens
UCSD research leads to tool that might help researchers to track and attack pathogenic bacteria
A new player in New Jersey
A new player in New Jersey
ATCC and ILSE announce establishment of translational microbiology center
A CRISPR approach
A CRISPR approach
NHGRI scientists combine CRISPR/Cas9 and zebrafish for high-throughput, multiplexed gene editing
Preclinical
Relying on Reolysin
Relying on Reolysin
Oncolytics sees promising results from reovirus compound in combination therapy regimens
Arno explores new class of antimicrobial drugs
Arno explores new class of antimicrobial drugs
Work includes possible biodefense and public health applications for compound known as AR-12
Fighting pain fivefold better?
Fighting pain fivefold better?
Studies indicate boronicaine may provide pain relief five times longer than lidocaine and be an alternative type of anesthetic
Making migraine less of a pain
Making migraine less of a pain
Researchers establish that vagus nerve stimulation is effective in suppressing cortical spreading depression, a trigger for migraine
Discovery
A boost for immunology
A boost for immunology
Lilly and Sanford Burnham Prebys collaborate to discover, develop therapies for lupus, Sjögren’s and more
Trucking along with CAR T
Trucking along with CAR T
Juno keeps busy with partnerships, purchases supporting its T cell technology
Partner pairing
Partner pairing
Adimab announces antibody collaborations with Celgene and Kite
Old is new again
Old is new again
Decades-old antibiotic could be the key to new melanoma treatment
TSRI study points to unexplored realm of protein biology and potential new drug targets
TSRI study points to unexplored realm of protein biology and potential new drug targets
TSRI study points to unexplored realm of protein biology and potential new drug targets
Business & Government Policy
Danaher to acquire Pall for $13.8 billion
Danaher to acquire Pall for $13.8 billion
Move represents company’s progress away from manufacturing and toward healthcare instrumentation
Broadening its immuno-oncology options
Broadening its immuno-oncology options
Cellular Biomedicine Group to acquire vaccine for use in lung cancer clinical trial
Shire rumored to be shopping for Swiss biotech
Shire rumored to be shopping for Swiss biotech
U.K.-based company’s reported $18.9- billion offer sends Actelion shares soaring, but apparently not its heart
Patent Docs: BIO International Convention wrap-up
Patent Docs: BIO International Convention wrap-up
The Biotechnology Industry Organization, or BIO, held its 2015 BIO International Convention in Philadelphia June 15-18, with more than 15,000 attendees and in excess of 1,700 exhibitors in the exhibit hall
On the cutting edge
On the cutting edge
A roundup of instrumentation, software and other tools and technology news
Diagnostics
Fluxion, Swift team up on NGS workflow for liquid biopsies
Fluxion, Swift team up on NGS workflow for liquid biopsies
Fluxion Biosciences Inc. and Swift Biosciences Inc. announced a new workflow for oncology clinical research designed to detect somatic mutations from a routine blood draw
Working all the angles
Working all the angles
Parsortix technology from ANGLE shows major promise in cancer detection and diagnosis
Paired against pancreatic cancer
Paired against pancreatic cancer
Halozyme and Ventana to jointly develop PEGPH20 to fight metastatic pancreatic cancer
Out of the lab, into the hospital
Out of the lab, into the hospital
Study examines potential of whole-genome sequencing in standard patient care
New data support continued onapristone and CDx development
New data support continued onapristone and CDx development
Arno presents data from three abstracts during ASCO’s ‘Gynecologic Cancer’ and ‘Genitourinary (Prostate) Cancer’ poster sessions
Q&A
Q&A: Keeping it small (molecule) and focused on cancer
Q&A: Keeping it small (molecule) and focused on cancer
DDNews talks to Timothy Clackson, Ph.D., president of research and development at ARIAD, about the company's drug discovery programs and structure-based drug design to create molecules that overcome resistance to existing treatments
Editor's Focus
M&As: Let’s serve ‘em up rare and juicy
M&As: Let’s serve ‘em up rare and juicy
The rare disease/orphan disease space has become quite the hot commodity for many pharmas as they look to merger and acquisition deals; but are some of them overreaching and are we getting to a tipping point soon?
Commentary
Out of Order: Picture this, will you?
Out of Order: Picture this, will you?
Pharmas and biotechs of all sizes would benefit greatly by a small investment of time and money into cameras and making photos of their executives and operations easily accessible
Commentary: The changing face of nonclinical development
Commentary: The changing face of nonclinical development
CROs are adapting service offerings to provide customers with increased understanding of drug mechanism of action on safety studies
Special Reports
Cell Biology Special Report: Feeling out phenotypes
Cell Biology Special Report: Feeling out phenotypes
Using omics approaches, researchers digitize the analog world of cell biology
