July 2010 Volume 6, Issue 7

Volume 6, Issue 7 | July 2010

July 2010

In this Issue

Global News

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Does Aspen have cure for a sick Sigma?

There are signs that Aspen Pharmacare may want to acquire Sigma, but challenges abound
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A cardiovascular collaboration

ElexoPharm expands Merck’s cardiovascular pipeline with aldosterone synthase inhibitors
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Japanese, if you please

sanofi-aventis and Japan’s Nichi-Iko form generics joint venture
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Profits go north in the Far East

Multibillion-dollar Piramal deal in India makes Abbott one of biggest players in Asian emerging markets, branded generics

News Briefs

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A step up for systems biology

Life Technologies partners with German Cancer Research Center to create world-class genome sequencing facility

Research & Development

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Respiration collaboration

Centocor Ortho Biotech acquires RespiVert to bolster pulmonary focus, boosting pulmonary portfolio and capabilities
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Deep in the heart of Texas

MD Anderson Cancer Center, Texas A&M’s partner in war against cancer
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All of a mind on brain tumor vaccine

Recent glioblastoma vaccine deal with NCI in the States complements earlier immatics’ agreement with Cancer Research UK
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Strength in numbers

Merck launches global network of cancer centers to accelerate cancer trials and improve collaborative research efforts
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High-figure deal marks growth in medical device market

Covidien boosts vascular platform with $2.6 billion acquisition of medical device maker ev3

Omics & Systems Biology

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New type of human stem cell may be more easily manipulated

Researchers at Massachusetts General Hospital and Harvard Stem Cell Institute say cells should be more useful for research, future therapies
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Two four-year olds study digital proteomic signatures

Affomix and the PGx Centre to develop reagents that will enable the quantitative multiplexed profiling of strategic proteins predictive of drug efficacy and toxicity
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Ultrasound and fury

Philips and RXi Pharmaceuticals look to fight disease by jointly researching innovative image-guided, RNAi-based therapy
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Going after GPCRs

Scynexis to aid Trevena’s ongoing search for biased GPCR ligand drugs
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NIH Human Microbiome Project researchers publish first genomic collection of human microbes

Diversity of human microbes greater than previously predicted

Special Reports

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Stepping out from behind the curtain

Five CROs offer a glimpse into their business and the future of the industry
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Reg-ing them over the coals

Increasing government regulation might be a significant part of the push to outsource more pharma and biotech functions

Diagnostics

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Taking a breakthrough to the masses

ZyGEM acquires MicroLab Diagnostics to commercialize DNA testing, detection platform
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GE Healthcare dreams big with $5 million investment in CardioDx

Companies to advance development of new tools to diagnose cardiovascular disease with first healthymagination fund investment
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Cancer consortium to continue

Germany’s GATC Biotech to carry on sequencing of pediatric brain tumors for the International Cancer Genome Consortium
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Sharp strategy, broad reach

Clovis Oncology and Avila Therapeutics sign $209 million agreement for the worldwide development and commercialization of EGFR mutant-selective inhibitor

Government Watch

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In the interest of full disclosure

NIH proposes federal rule requiring researchers to publicly report payments from pharma companies
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Synthetic biology ‘not life from scratch,’ researcher says

U.S. Congress hears benefits, ethical concerns associated with synthetic biology
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OSHA seeks reform of lab safety standards

Agency calls for public comment on occupational risks of and procedures for handling infectious agents
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Top 10 FDA Advisory Committee tips

Drug development consultant shares best practices for delivering a successful argument before regulators
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Showing bioscience the money

Maryland proposal could boost venture capital for bioscience companies

Instruments & Informatics

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Putting down the bottle(necks)

BIOCIUS and Agilent launch mass spec solution that eliminates need for test compound-specific methods
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Two knowledge management companies join forces to provide integrated solutions

Ariadne and Aureus Pharma to collaborate on technologies and applications in support of knowledge management solutions
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Adding more PDQ and A-OK for qPCR

Exiqon and MultiD sign development and distribution agreement to provide specifically adapted microRNA qPCR analysis solution
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The 5,000 human protein club

OriGene Technologies, Institute for Systems Biology to create standard database for 5,000 human proteins

Commentary

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Commentary: The importance of liquid handling quality assurance through the drug discovery process

The choice of reverse- or forward-mode pipetting is often based on operator preference, but choosing the right technique can help to minimize error in automated liquid handling.

Patent News

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When it comes to patent term extensions, an enantiomer is a different drug from racemate

The U.S. Court of Appeals for the Federal Circuit recently rendered a decision in Ortho-McNeil Pharmaceutical Inc. v. Lupin Pharmaceuticals Inc. on the question of whether separate enantiomers can have “first commercial marketing or use” status for purposes of patent term extension under 35 U.S.C. § 156.

Editor's Focus

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Our pharma, ‘tis of thee

With many of us gathering on the fourth of this month to celebrate the birth of our country, it’s a good time to assess the state of U.S. pharma and biotech markets.

New Products

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Complete sample storage solution for biobanking, repositories

Micronic offers a full range of biological and cryogenic sample storage tubes, sealing arrangements, tube racks, tube sorters and Track-IT—a new sample management system interfaced to a 2D code reader that allows users to reliably and efficiently organize and track individual samples.
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New SsoFast probes supermix to accelerate gene expression analysis

Bio-Rad Laboratories Inc. introduces SsoFast probes supermix, a reagent that enables researchers using fluorogenic probes to enhance the speed, reliability and sensitivity of their qPCR experiments.
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Shimadzu introduces data analysis technologies

Shimadzu Scientific Instruments has taken the wraps off several new products, including AXIMA MegaTOF, an integrated MALDI solution from Shimadzu and CovalX for ultra high-mass applications that detect intact complexes up to 1.5 MDa.; Nexera Ultra High-Performance Liquid Chromatograph, which meets all analysis requirements with no compromise in data integrity; Nanotrap Biomarker Discovery Platform, which gives researchers the ability to enrich, preserve and screen low-level biomarkers directly from complex biological samples; and Component ID Solution, software that accelerates high-confidence component identification using the power of high-mass accuracy and the simplicity of an open-access workflow.
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Pipette tips that ensure pipette connection

GripTips are a next- generation range of pipette tips that ensure the perfect connection between pipette and tip. GripTips have been engineered to provide unmatched high lateral resistance.
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Recombinant Human Granulocyte Macrophage Colony Stimulating Factor

Recombinant Human Granulocyte Macrophage Colony Stimulating Factor (rHu GM-CSF) is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation.
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A closer look at the tumor microenvironment 

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Discover how digitization improves data integrity and accelerates decision-making in biotherapeutics development. 
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