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November 2024

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January 2024

A small shopping card holds one gray insulin pen and one blue insulin pen. Blue and white boxes and caps for the pens sit next to the cart.

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To help bring their discoveries to the public, researchers should implement strategies to enhance access throughout the drug development process.

Drug accessibility is everyone&rsquo;s job

A photo of MJ Kievman, the founder and CEO of Meter Health, who experienced hiccups as a young child and developed Hiccupops, a lollipop to stop hiccups.

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Ali Seifi, a neurointensivist at the University of Texas, San Antonio who created the HiccAway straw to stop hiccups.

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A photo of Mark Fox, a gastroenterologist at the University of Zürich and an expert on hiccups.

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Nicole Allard, who experienced chronic hiccups for 15 years, sits atop a hill with red flowers overlooking a valley with green brush and wetlands in Alaska.

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An illustration of how the vagus and phrenic nerves stretch across the body and coordinate sensory signals to control the rise and fall of the diaphragm, resulting in the rapid opening and closing of the glottis during a hiccup. 

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A photo of a blue HiccAway straw, which stops hiccups when sucked on, sitting in a glass of water. 

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Two product boxes for the orange citrus and sour apple flavors of Hiccupops. 

A photo of Claudia Bush, an anesthesiologist at the University of Heidelberg, who is building a local patient registry to better understand hiccups. 

Researchers and patients developed unexpected and innovative solutions to a mysterious disease that appears as little more than a hiccup.

The chronic hiccup chronicles

Zhou Xing wears a lab coat while sitting at a bench in his laboratory at McMaster University.

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Brittany Hartwell leans against a lab bench in her postdoctoral research lab at MIT.

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A woman blows her nose into a tissue while covered by a blanket and sitting on a couch.

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Darrell Irvine stands in a hallway with science illustrations on the wall.

Pathogens invade mucosal surfaces like the nose, but typical vaccines don&#39;t mount an immune response there. Newly engineered mucosal vaccines, however, do.

From COVID-19 to TB, mucosal vaccines stop infections before they start

Editor's Focus

A headshot of Clark Rosen wearing a blue shirt, dark blazer, and navy and gold striped tie. 

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A headshot of Johnathon Anderson wearing a blue shirt, blue tie, and white lab coat. 

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A headshot of Ed Steger wearing a blue checked shirt. 

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A woman wearing a blue shirt presses her hand to the throat of a mean wearing a blue shirt and drinking from a blue cup. 

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A schematic showing a purple satellite cell and a yellow lightning bolt representing muscle injury. The differentiation pathway shows sequential arrows leading to yellow myoblast cells, pink myocyte cells, a red tube (myotube), and a red bundle of tubes (myofiber). The self-renewal pathway shows a curved arrow leading to a cluster of purple satellite cells.  

Injecting muscle-derived cells into the tongue could help alleviate swallowing difficulties caused by head and neck cancer treatment.

Making cancer treatment easier to swallow

A headshot of Ronit Simantov standing outside next to a tree and wearing glasses.

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Natural killer cells represented in light grey surround a cancer cell shown as a red ball with red branches coming off of it.

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A headshot of Veronika Bachanova wearing a green top and blazer.

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Katayoun Rezvani pipets red liquid from a flask while working in a biosafety hood.

Natural killer cells offer safe and effective cancer treatment, but to succeed in the clinic, they need a bit of an energy boost.

Powering up natural killer cells to fight cancer

Cell Therapy

A headshot of Rhonda Voskuhl wearing a white lab coat.

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A drawing of a pregnant woman showing a fetus. 

A series of black and white MRI images of the brain. 

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A drawing of a person’s head showing their brain with blue and purple flashes of light. Next to the head are two neurons, one with a damaged myelin sheath and one with an intact myelin sheath. 

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A headshot of Ari Green wearing a purple shirt, tie, and white coat. 

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Molecules that promote restoration of the neuron&rsquo;s myelin sheath could offer a reparative therapy for multiple sclerosis.

A recipe for remyelination

Gabriel Rabinovich wears glasses and a dark blue shirt. 

Illustration depicting hospital staff administering immunotherapy to patients. 

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Seven people in white coats in a laboratory. The first five from left to right are standing and the remaining two are sitting, one of them holding a computer.

Immunologist Gabriel Rabinovich leverages his 30 years of experience studying sugar-binding proteins, galectins, for developing novel therapies.

Sweetening the fight against cancer and autoimmune diseases

Autoimmune Disease

A headshot of Yangzhi Zhu wearing a black blazer, pink shirt, and pink bowtie.

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A 3D illustration of graphene shows a single layer of carbon atoms arranged in a hexagonal lattice.

A close-up shot of an eye shows a contact lens over the iris and redness in the white of the eye. 

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A photo of Matsuhiko Nishizawa wearing a black shirt and holding up a contact lens prototype. 

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A photo of the microfluidic contact lens shows a clear circle with curved microfluidic channels and inlet and outlet reservoirs.

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Researchers are developing next-generation contact lenses that combat the disrupted fluid dynamics behind contact lens-induced dry eye syndrome.

A dry eye problem offers a solution

NASA Astronaut Josh Cassada wears a grey T-shirt as he floats in the International Space Station.

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Michael Gelinsky wears a dark shirt and pants in a photo indoors.

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Markus Braun wears a blue shirt in a photo taken outside.

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Nieves Cubo-Mateo wears a black suit jacket and stands in front of a row of 3D printers.

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Redwire’s 3D BioFabrication Facility (BFF) on the ISS.

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Matthias Maurer places the Bioprint First Aid 3D bioprinter on his leg as a woman with dark hair watches him.

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Scientists use 3D bioprinting in space to create tissues and organoids that would otherwise be difficult to make in the presence of gravity.

3D bioprinting tissues in space to heal people on Earth

Bioengineering

In the top left, an atomic force microscopy image of a group of light brown TRPV3 ion channels against a black background with white arrow heads pointing to a tetramer and pentamer. In the top right, a close up atomic force microscopy image of the tetramer and pentamer. In the bottom left, a cryogenic electron microscopy structure of the tetramer with the four subunits shown in yellow, green, orange and purple. In the bottom right, a cryogenic electron microscopy structure of the pentamer with the five subunits shown in yellow, green, orange, purple, and pink. 

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On the left, an atomic force microscopy image of a group of light brown TRPV3 ion channels is shown against a black background with white arrow heads pointing to a tetramer and pentamer. In the top right, a close up atomic force microscopy image of the tetramer and pentamer is shown. 

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Microscopy images reveal the structural change that enlarges an ion channel pore, opening new directions in drug discovery and delivery.

Zooming in on pore dilation

Proteins

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A 3D rendering of lipid nanoparticles delivering RNA strands

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Inotiv

As lipid nanoparticles become promising drug carriers, understanding their potential genotoxic risks is crucial.&nbsp;

Ensuring safety in lipid nanoparticle drug delivery

Webinars

A scientist wearing gloves handles a pipette over a petri dish and a color-coded microplate in a laboratory setting.

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Sartorius

Learn how fundamental laboratory tools like pipettes and balances support analytical precision.

The unsung tools behind analytical testing success

Application Note

A 3D rendering of motor neurons lit up with blue, purple, orange, and green coloring showing synapses against a black background.

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Discover new advancements in modeling amyotrophic lateral sclerosis.

January 2024 Volume 20, Issue 1