January 2024- Volume 20, Issue 1

In this Issue

Editor's Focus

A woman blows her nose into a tissue while covered by a blanket and sitting on a couch.

From COVID-19 to TB, mucosal vaccines stop infections before they start

From COVID-19 to TB, mucosal vaccines stop infections before they start

Pathogens invade mucosal surfaces like the nose, but typical vaccines don't mount an immune response there. Newly engineered mucosal vaccines, however, do.
A small shopping card holds one gray insulin pen and one blue insulin pen. Blue and white boxes and caps for the pens sit next to the cart.

Drug accessibility is everyone’s job

Drug accessibility is everyone’s job

To help bring their discoveries to the public, researchers should implement strategies to enhance access throughout the drug development process.
Nicole Allard, who experienced chronic hiccups for 15 years, sits atop a hill with red flowers overlooking a valley with green brush and wetlands in Alaska.

The chronic hiccup chronicles

The chronic hiccup chronicles

Researchers and patients developed unexpected and innovative solutions to a mysterious disease that appears as little more than a hiccup.

Autoimmune Disease

Illustration depicting hospital staff administering immunotherapy to patients.

Sweetening the fight against cancer and autoimmune diseases

Sweetening the fight against cancer and autoimmune diseases

Immunologist Gabriel Rabinovich leverages his 30 years of experience studying sugar-binding proteins, galectins, for developing novel therapies.
A drawing of a person’s head showing their brain with blue and purple flashes of light. Next to the head are two neurons, one with a damaged myelin sheath and one with an intact myelin sheath.

A recipe for remyelination

A recipe for remyelination

Molecules that promote restoration of the neuron’s myelin sheath could offer a reparative therapy for multiple sclerosis.

Bioengineering

A close-up shot of an eye shows a contact lens over the iris and redness in the white of the eye.

A dry eye problem offers a solution

A dry eye problem offers a solution

Researchers are developing next-generation contact lenses that combat the disrupted fluid dynamics behind contact lens-induced dry eye syndrome.
NASA Astronaut Josh Cassada wears a grey T-shirt as he floats in the International Space Station.

3D bioprinting tissues in space to heal people on Earth

3D bioprinting tissues in space to heal people on Earth

Scientists use 3D bioprinting in space to create tissues and organoids that would otherwise be difficult to make in the presence of gravity.

Cell Therapy

A woman wearing a blue shirt presses her hand to the throat of a mean wearing a blue shirt and drinking from a blue cup.

Making cancer treatment easier to swallow

Making cancer treatment easier to swallow

Injecting muscle-derived cells into the tongue could help alleviate swallowing difficulties caused by head and neck cancer treatment.
Natural killer cells represented in light grey surround a cancer cell shown as a red ball with red branches coming off of it.

Powering up natural killer cells to fight cancer

Powering up natural killer cells to fight cancer

Natural killer cells offer safe and effective cancer treatment, but to succeed in the clinic, they need a bit of an energy boost.

Proteins

On the left, an atomic force microscopy image of a group of light brown TRPV3 ion channels is shown against a black background with white arrow heads pointing to a tetramer and pentamer. In the top right, a close up atomic force microscopy image of the tetramer and pentamer is shown.

Zooming in on pore dilation

Zooming in on pore dilation

Microscopy images reveal the structural change that enlarges an ion channel pore, opening new directions in drug discovery and delivery.
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