January 2019 Volume 15, Issue 1

Volume 15, Issue 1 | January 2019

January 2019

In this Issue

Research & Development

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Scripps researchers unlock heart disease key

9p21.3 haplotype identified as a major player in cardiovascular disease risk
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East meets West in new therapeutics quest

Partners launch multitarget development alliance worth up to $310M
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An updated portfolio for uniQure

Gene therapy company showcases new therapies and its gene silencing platform
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Count Me In seeks to speed progress against cancer

A new model of patient-partnered research is at the core of recently launched nonprofit organization

Preclinical

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Spray away tumors?

Gel developed at UCLA could help body fight off cancer after surgery
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A new twist on immunotherapy

Research team reports on a method for altering B cells to create a new anticancer weapon
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A link between sugar and cancer

U.K.-based researchers find that mannose can impede tumors
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Nexien collaboration to focus on preclinical cannabinoid studies

Partnership will investigate advanced parenteral formulations for acute treatment of convulsive disorders
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ALG.APV-527 activates and enhances T cells and NK cells

Alligator Bioscience and Aptevo Therapeutics presented on potential therapeutic at SITC annual meeting

Business & Government Policy

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Paying out for PARP

GSK acquires TESARO—and its PARP inhibitor Zejula—for $5.1 billion
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China-bound for Merus and Promega

A license deal and innovation designation, respectively, give both companies a toe in Chinese pharma waters
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On the cutting edge

A roundup of instrumentation, software and other tools and technology news
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MyoKardia and Sanofi part ways in collaboration

MyoKardia regains global rights to mavacamten and MYK-491 programs
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A ray of hope in patenting “products of nature” perhaps?

In a recent decision by the Federal Circuit, Roche Molecular Inc. v. Cepheid, the court raised for the first time a question regarding whether it may have over-interpreted the scope of the Supreme Court’s proscription regarding patenting compositions arising from products produced in nature in AMP v. Myriad Genetics

Special Reports

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Special Report on Microbiomics: Army of One

Finding alliances between microbes and immune cells

Commentary

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Market insight: AI and causal machine learning are accelerating discovery and more

The power of causal machine learning allows us to apply sophisticated algorithms directly to massive and complex data and accelerate the discovery of cause-and-effect relationships
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Out of order: Removing blinders

We may try to separate the mind from the rest of the body in science a lot of the time, but it turns out the microbiome might extend there as well

Editor's Focus

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Editor’s focus: A ‘Q’ for ‘quality’ in Q1?

Let's take a look at the special features in store for you at DDNews in the first quarter of 2019

Feature

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SLAS 2019 Show Preview: A capital time for collaboration in the SLAS community

Washington, D.C., welcomes 2019’s annual meeting of the Society for Laboratory Automation and Screening

Discovery

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Lilly, Dicerna to embark on RNAi research collaboration

Companies will focus on gene-silencing targets in the areas of cardio-metabolic disease, neurodegeneration and pain
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Going after glioblastoma

1ST Biotherapeutics and twoXAR Form co-development collaboration to discover and develop new brain cancer treatments
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A technology to predict biochemical reactions

Fujitsu platform could help clarify the mechanisms of genetic disorders and advance drug discovery

Clinical Trials

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Relieving rhinitis

ASIT begins confirmatory trial of grass pollen allergy injection
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Neurocrine reevaluates Tourette program

Valbenazine fails to meet the primary endpoint in Phase 2b trial in pediatric patients
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Breakthrough: WP1066 inhibits PD-L1 as well as STAT3

Moleculin’s drug, which recently began a trial for aggressive brain tumors, counteracts resistance to checkpoint blockades
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Verrica announces positive top-line results from Phase 3 trials of VP-102

CAMP-1 and CAMP-2 trials for molluscum contagiosum both achieve statistical significance for the primary endpoint with p-values less than 0.0001

Diagnostics

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Progentec Diagnostics brings in LupusCorner

New funding brings lupus-detection tools closer to commercialization; acquisition of LupusCorner marks another step forward
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Collaboration speeds access to cancer drugs

QIAGEN and NeoGenomics seek to explore potential of changes in FDA’s approach to advanced diagnostics and NGS tests
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Nanoscale technique set to springboard cancer discoveries

University of Manchester researchers able to get more data from blood of cancer patients than previously possible
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Newly published data support PancraGEN

Peer-reviewed journal article highlights important role of Interpace Diagnostics’ test for pancreatic cysts

Contract Services

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PPD expands lab capabilities in Athlone

Company enhances gene and cell therapy lab services in Europe and North America
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Admescope launches new services

Company looks to serve growing biologics market
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New PDAC research

Findings published in Journal of Visualized Experiments
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