January 2019- Volume 15, Issue 1

In this Issue

Clinical Trials

Neurocrine reevaluates Tourette program

Neurocrine reevaluates Tourette program

Valbenazine fails to meet the primary endpoint in Phase 2b trial in pediatric patients

Breakthrough: WP1066 inhibits PD-L1 as well as STAT3

Breakthrough: WP1066 inhibits PD-L1 as well as STAT3

Moleculin’s drug, which recently began a trial for aggressive brain tumors, counteracts resistance to checkpoint blockades

Verrica announces positive top-line results from Phase 3 trials of VP-102

Verrica announces positive top-line results from Phase 3 trials of VP-102

CAMP-1 and CAMP-2 trials for molluscum contagiosum both achieve statistical significance for the primary endpoint with p-values less than 0.0001

Relieving rhinitis

Relieving rhinitis

ASIT begins confirmatory trial of grass pollen allergy injection

Diagnostics

Progentec Diagnostics brings in LupusCorner

Progentec Diagnostics brings in LupusCorner

New funding brings lupus-detection tools closer to commercialization; acquisition of LupusCorner marks another step forward

Collaboration speeds access to cancer drugs

Collaboration speeds access to cancer drugs

QIAGEN and NeoGenomics seek to explore potential of changes in FDA’s approach to advanced diagnostics and NGS tests

Nanoscale technique set to springboard cancer discoveries

Nanoscale technique set to springboard cancer discoveries

University of Manchester researchers able to get more data from blood of cancer patients than previously possible

Newly published data support PancraGEN

Newly published data support PancraGEN

Peer-reviewed journal article highlights important role of Interpace Diagnostics’ test for pancreatic cysts

Contract Services

PPD expands lab capabilities in Athlone

PPD expands lab capabilities in Athlone

Company enhances gene and cell therapy lab services in Europe and North America

Admescope launches new services

Admescope launches new services

Company looks to serve growing biologics market

New PDAC research

New PDAC research

Findings published in Journal of Visualized Experiments

Research & Development

An updated portfolio for uniQure

An updated portfolio for uniQure

Gene therapy company showcases new therapies and its gene silencing platform

Count Me In seeks to speed progress against cancer

Count Me In seeks to speed progress against cancer

A new model of patient-partnered research is at the core of recently launched nonprofit organization

East meets West in new therapeutics quest

East meets West in new therapeutics quest

Partners launch multitarget development alliance worth up to $310M

Scripps researchers unlock heart disease key

Scripps researchers unlock heart disease key

9p21.3 haplotype identified as a major player in cardiovascular disease risk

Business & Government Policy

China-bound for Merus and Promega

China-bound for Merus and Promega

A license deal and innovation designation, respectively, give both companies a toe in Chinese pharma waters

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

MyoKardia and Sanofi part ways in collaboration

MyoKardia and Sanofi part ways in collaboration

MyoKardia regains global rights to mavacamten and MYK-491 programs

A ray of hope in patenting “products of nature” perhaps?

A ray of hope in patenting “products of nature” perhaps?

In a recent decision by the Federal Circuit, Roche Molecular Inc. v. Cepheid, the court raised for the first time a question regarding whether it may have over-interpreted the scope of the Supreme Court’s proscription regarding patenting compositions arising from products produced in nature in AMP v. Myriad Genetics

Paying out for PARP

Paying out for PARP

GSK acquires TESARO—and its PARP inhibitor Zejula—for $5.1 billion

Preclinical

A new twist on immunotherapy

A new twist on immunotherapy

Research team reports on a method for altering B cells to create a new anticancer weapon

A link between sugar and cancer

A link between sugar and cancer

U.K.-based researchers find that mannose can impede tumors

Nexien collaboration to focus on preclinical cannabinoid studies

Nexien collaboration to focus on preclinical cannabinoid studies

Partnership will investigate advanced parenteral formulations for acute treatment of convulsive disorders

ALG.APV-527 activates and enhances T cells and NK cells

ALG.APV-527 activates and enhances T cells and NK cells

Alligator Bioscience and Aptevo Therapeutics presented on potential therapeutic at SITC annual meeting

Spray away tumors?

Spray away tumors?

Gel developed at UCLA could help body fight off cancer after surgery

Discovery

Lilly, Dicerna to embark on RNAi research collaboration

Lilly, Dicerna to embark on RNAi research collaboration

Companies will focus on gene-silencing targets in the areas of cardio-metabolic disease, neurodegeneration and pain

Going after glioblastoma

Going after glioblastoma

1ST Biotherapeutics and twoXAR Form co-development collaboration to discover and develop new brain cancer treatments

A technology to predict biochemical reactions

A technology to predict biochemical reactions

Fujitsu platform could help clarify the mechanisms of genetic disorders and advance drug discovery

Special Reports

Commentary

Market insight: AI and causal machine learning are accelerating discovery and more

Market insight: AI and causal machine learning are accelerating discovery and more

The power of causal machine learning allows us to apply sophisticated algorithms directly to massive and complex data and accelerate the discovery of cause-and-effect relationships

Out of order: Removing blinders

Out of order: Removing blinders

We may try to separate the mind from the rest of the body in science a lot of the time, but it turns out the microbiome might extend there as well

Editor's Focus

Editor’s focus: A ‘Q’ for ‘quality’ in Q1?

Editor’s focus: A ‘Q’ for ‘quality’ in Q1?

Let's take a look at the special features in store for you at DDNews in the first quarter of 2019

Feature

SLAS 2019 Show Preview: A capital time for collaboration in the SLAS community

SLAS 2019 Show Preview: A capital time for collaboration in the SLAS community

Washington, D.C., welcomes 2019’s annual meeting of the Society for Laboratory Automation and Screening
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