January 2017 Volume 13, Issue 1

Volume 13, Issue 1 | January 2017

January 2017

In this Issue

Clinical Trials

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MPC-HSC synergy vs. cancer

MD Anderson and NIH fund trial combining Mesoblast technologies for rapid engraftment of stem cell transplants
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Orchard’s efforts bear fruit

U.K.-based company receives $20 million for clinical trial of ADA-SCID
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Getting control of bleeding

Spark and Pfizer announce updated data for ongoing hemophilia B study
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Making a dent in advanced refractory cancer

Corvus’ CPI-444 shows promise for disabling a tumor’s ability to subvert attack by the immune system
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Alopexx presents encouraging lymphoma results

Data for Phase 1 study of DI-Leu16-IL2 in relapsed/refractory NHL presented at ASH 2016

Discovery

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Hope for rare diseases

Illumina kicks off iHope initiative for undiagnosed children
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Bristol-Myers Squibb and Enterome join forces

Companies announce oncology deal around discovery of immunotherapy agents and biomarkers
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‘Modulating’ tumor treatment

Albumedix and NYU School of Medicine team up to target novel cellular pathways in oncology
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Targeting genetically defined neurodegenerative diseases

Sharp Edge Labs enters into drug discovery collaboration with Sumitomo Dainippon Pharma
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Heptares gains G7 Therapeutics

Acquisition is aimed at extending leadership in GPCR- focused drug discovery and development

Research & Development

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Building better models of organs

QGel’s designer matrices promising for organoid culture and cancer therapy development
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A circadian component to cancer?

Disruption in circadian rhythms might be implicated in other unexpected disease areas, too, like diabetes and sepsis
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Deciphering immune response

French researchers offer new global approach for predicting individual immune responses
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Molecular motor has a ‘gear’ for directional switching

Research aids understanding of complex cellular machinery used to ensure normal cell division
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AbbVie partners with Johns Hopkins and Northwestern on cancer research

Pair of five-year collaboration deals announced on the same day look to be headed in similar directions

Feature

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SLAS2017 Show Preview: Putting together a ‘Capitol’ event

SLAS2017 will bring a wealth of scientific and other programming to Washington, D.C., in February

Special Reports

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Special Report on Microbiomics: The aliens within us

As if human diversity wasn’t tricky enough

Commentary

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Publishers’ commentary: From an amazing 2016 to a promising 2017

Reviewing the past year and highlighting what's to come in DDNews
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Out of Order: Undaunted

Life sciences in general, and pharma/biotech along with it, moves fast, and our hats are off to the researchers who are trying to keep pace
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Guest Commentary: Sample-handling automation

The big changes still coming, and how to adapt to a changing world

Diagnostics

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Resisting antibiotic resistance

OpGen, Merck to develop rapid-fire diagnostics and informatics to combat antibiotic resistance
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Twice the power for two-gene test

Clinical Genomics’ ctDNA blood test outperforms CEA in detecting colorectal cancer recurrence
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‘Knowing is key’

New saliva test aims to predict future onset of Alzheimer’s disease
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Sequencing of events

A quick roundup of some late-2016 genomics-based diagnostics news

Contract Services

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Meaningful marriage

Bionical acquires Emas to deliver improved health outcomes
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A multitude of models

CrownBio introduces new in-vivo platforms for renal research
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Improving clinical trial efficiency

Medpace selects Montrium Connect EDMS to make clinical trials more efficient and support continued global business growth
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Envigo invests in STAG

Envigo announced in fall 2016 the launch of a dedicated Science and Technology Advisory Group

Preclinical

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Hope for hemophiliacs

New research into subcutaneous factor replacement therapy could offer IV alternative
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A new treatment combo for RCC

Preclinical data demonstrate functional activity of AGS-003-like therapy in kidney cancer murine model
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No lack of potential for NK cells

Affimed shares preclinical data on AFM13, AFM11, trispecific antibodies
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Kura presents data on KO-947 and menin-MLL in Munich

Company targets first half of 2017 for a trial of KO-947, describes as a ‘potent inhibitor’ of ERK

Business & Government Policy

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Spin out and launch

Celgene acquires Acetylon, which spins out Regenacy
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On the cutting edge

A roundup of instrumentation, software and other tools and technology news
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Tenaya Therapeutics launches to go after heart disease

With $50M investment, Gladstone Institutes look to push basic science discoveries toward cures for heart disease
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Follow-up data on Imbruvica at ASH 2016

Findings show strong, lasting efficacy of Imbruvica through five years of treatment for CLL/SLL
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Patent Docs: Solicitor General recommends that the Supreme Court review Federal Circuit decision in Sandoz v. Amgen

These recommendations are significant, because the Supreme Court asks the government for its views under those circumstances inter alia where there are important policy considerations at stake
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Overcoming barriers in gene therapy 

Advanced gene editing, delivery, and analytical tools are driving better gene therapies.
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A multiomic approach to profiling brain tumors

Probing the molecular drivers of brain metastasis reveals novel therapeutic targets.
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Enhancing immune cell profiling with digital technologies 

Software innovations help researchers decode immune complexity in cancer.
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