January 2017- Volume 13, Issue 1

In this Issue

Business & Government Policy

Patent Docs: Solicitor General recommends that the Supreme Court review Federal Circuit decision in Sandoz v. Amgen

Patent Docs: Solicitor General recommends that the Supreme Court review Federal Circuit decision in Sandoz v. Amgen

These recommendations are significant, because the Supreme Court asks the government for its views under those circumstances inter alia where there are important policy considerations at stake

Spin out and launch

Spin out and launch

Celgene acquires Acetylon, which spins out Regenacy

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

Tenaya Therapeutics launches to go after heart disease

Tenaya Therapeutics launches to go after heart disease

With $50M investment, Gladstone Institutes look to push basic science discoveries toward cures for heart disease

Follow-up data on Imbruvica at ASH 2016

Follow-up data on Imbruvica at ASH 2016

Findings show strong, lasting efficacy of Imbruvica through five years of treatment for CLL/SLL

Preclinical

Hope for hemophiliacs

Hope for hemophiliacs

New research into subcutaneous factor replacement therapy could offer IV alternative

A new treatment combo for RCC

A new treatment combo for RCC

Preclinical data demonstrate functional activity of AGS-003-like therapy in kidney cancer murine model

No lack of potential for NK cells

No lack of potential for NK cells

Affimed shares preclinical data on AFM13, AFM11, trispecific antibodies

Kura presents data on KO-947 and menin-MLL in Munich

Kura presents data on KO-947 and menin-MLL in Munich

Company targets first half of 2017 for a trial of KO-947, describes as a ‘potent inhibitor’ of ERK

Clinical Trials

Orchard’s efforts bear fruit

Orchard’s efforts bear fruit

U.K.-based company receives $20 million for clinical trial of ADA-SCID

Getting control of bleeding

Getting control of bleeding

Spark and Pfizer announce updated data for ongoing hemophilia B study

Making a dent in advanced refractory cancer

Making a dent in advanced refractory cancer

Corvus’ CPI-444 shows promise for disabling a tumor’s ability to subvert attack by the immune system

Alopexx presents encouraging lymphoma results

Alopexx presents encouraging lymphoma results

Data for Phase 1 study of DI-Leu16-IL2 in relapsed/refractory NHL presented at ASH 2016

MPC-HSC synergy vs. cancer

MPC-HSC synergy vs. cancer

MD Anderson and NIH fund trial combining Mesoblast technologies for rapid engraftment of stem cell transplants

Discovery

Bristol-Myers Squibb and Enterome join forces

Bristol-Myers Squibb and Enterome join forces

Companies announce oncology deal around discovery of immunotherapy agents and biomarkers

‘Modulating’ tumor treatment

‘Modulating’ tumor treatment

Albumedix and NYU School of Medicine team up to target novel cellular pathways in oncology

Targeting genetically defined neurodegenerative diseases

Targeting genetically defined neurodegenerative diseases

Sharp Edge Labs enters into drug discovery collaboration with Sumitomo Dainippon Pharma

Heptares gains G7 Therapeutics

Heptares gains G7 Therapeutics

Acquisition is aimed at extending leadership in GPCR- focused drug discovery and development

Hope for rare diseases

Hope for rare diseases

Illumina kicks off iHope initiative for undiagnosed children

Diagnostics

Resisting antibiotic resistance

Resisting antibiotic resistance

OpGen, Merck to develop rapid-fire diagnostics and informatics to combat antibiotic resistance

Twice the power for two-gene test

Twice the power for two-gene test

Clinical Genomics’ ctDNA blood test outperforms CEA in detecting colorectal cancer recurrence

‘Knowing is key’

‘Knowing is key’

New saliva test aims to predict future onset of Alzheimer’s disease

Sequencing of events

Sequencing of events

A quick roundup of some late-2016 genomics-based diagnostics news

Research & Development

A circadian component to cancer?

A circadian component to cancer?

Disruption in circadian rhythms might be implicated in other unexpected disease areas, too, like diabetes and sepsis

Deciphering immune response

Deciphering immune response

French researchers offer new global approach for predicting individual immune responses

Molecular motor has a ‘gear’ for directional switching

Molecular motor has a ‘gear’ for directional switching

Research aids understanding of complex cellular machinery used to ensure normal cell division

AbbVie partners with Johns Hopkins and Northwestern on cancer research

AbbVie partners with Johns Hopkins and Northwestern on cancer research

Pair of five-year collaboration deals announced on the same day look to be headed in similar directions

Building better models of organs

Building better models of organs

QGel’s designer matrices promising for organoid culture and cancer therapy development

Contract Services

Meaningful marriage

Meaningful marriage

Bionical acquires Emas to deliver improved health outcomes

A multitude of models

A multitude of models

CrownBio introduces new in-vivo platforms for renal research

Improving clinical trial efficiency

Improving clinical trial efficiency

Medpace selects Montrium Connect EDMS to make clinical trials more efficient and support continued global business growth

Envigo invests in STAG

Envigo invests in STAG

Envigo announced in fall 2016 the launch of a dedicated Science and Technology Advisory Group

Feature

SLAS2017 Show Preview: Putting together a ‘Capitol’ event

SLAS2017 Show Preview: Putting together a ‘Capitol’ event

SLAS2017 will bring a wealth of scientific and other programming to Washington, D.C., in February

Commentary

Out of Order: Undaunted

Out of Order: Undaunted

Life sciences in general, and pharma/biotech along with it, moves fast, and our hats are off to the researchers who are trying to keep pace

Guest Commentary: Sample-handling automation

Guest Commentary: Sample-handling automation

The big changes still coming, and how to adapt to a changing world
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