February 2023- Volume 19, Issue 2
In this Issue
Editor's Focus
From dye to base editing, early aging may soon have a cure
From dye to base editing, early aging may soon have a cure
Kan Cao studies the rare aging disorder progeria to find a cure, and she’s ready to solve the mysteries of healthy human aging along the way.
What now for the amyloid hypothesis?
What now for the amyloid hypothesis?
The Alzheimer's disease research field has been beset by failed clinical trials and fraud. But researchers remain hopeful that a better understanding of the disease’s broader picture will lead to treatments.
Editors Insight
Making a mess of the tidy narrative
Making a mess of the tidy narrative
Accuracy doesn’t only apply to isolated facts, but to the overall picture they paint.
Vaccines
Tiny needles make a big impact for vaccine delivery
Tiny needles make a big impact for vaccine delivery
Microarray, or microneedle, patches could boost vaccine access in low- and middle-income countries.
Origami vaccines fold up to fight cancer
Origami vaccines fold up to fight cancer
As self-assembling structures, DNA and RNA origami vaccines hold vaccine components in precise numbers and arrangements to help the immune system attack tumors.
Aging
A new strategy for fighting age-related disease
A new strategy for fighting age-related disease
Drugs that target senescent cells could one day treat frailty, Alzheimer’s disease, or cancer.
Gene Therapy
Editing the cell’s transcripts
Editing the cell’s transcripts
For cases where gene editing simply won’t work, biochemist Aseem Ansari is working on a new idea: changing how cells regulate genes.
Gene editing: DNA versus RNA
Gene editing: DNA versus RNA
Researchers correcting the genetic causes of disease at the DNA or RNA level make their cases.
Metabolic Disease
The ticking clock of metabolic disease
The ticking clock of metabolic disease
Mitchell Lazar studies the transcription factors linking circadian disruption to obesity and diabetes.
Sequencing 100,000 genomes to revolutionize Nigerian genomics
Sequencing 100,000 genomes to revolutionize Nigerian genomics
With diseases like cancer and kidney disease on the rise in Africa, Segun Fatumo and his team are sequencing the genomes of 100,000 Nigerians to understand why.
Drops and drugs for diabetic vision loss
Drops and drugs for diabetic vision loss
Eye injections are the only way to treat diabetic retinopathy, but many refuse to get them. Now, eye drops and pills are on their way.
