February 2020- Volume 16, Issue 2

In this Issue

Business & Government Policy

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

The EMA and the U.K. after Brexit

The EMA and the U.K. after Brexit

United Kingdom withdrawal from European Union changes dynamics

Targets acquired

Targets acquired

A look at a few recent acquisition deals in the pharma world

Discovery

Partnering for pulmonary disease

Partnering for pulmonary disease

Rare disease-focused companies link up to identify, develop therapeutics

Can baldness be stopped?

Can baldness be stopped?

Mount Sinai shares new information regarding the dermal sheath found around hair follicles

Proprietary platform

Proprietary platform

Lodo reinvents environmentally sourced, natural product drug discovery

Making gold out of lead

Making gold out of lead

UC San Diego team identifies the molecule that allows Zika to enter brain cells—a discovery that could also lead to a new way to target brain cancer cells

Preclinical

Reversing resistance

Reversing resistance

Drug can affect non-Hodgkin’s lymphoma cell lines

Targeting cancer with Claudin 6

Targeting cancer with Claudin 6

BioNTech announces publication of preclinical data for a CARVac targeting Claudin 6

Transgene and BioInvent announce data for BT-001 in solid tumors

Transgene and BioInvent announce data for BT-001 in solid tumors

Broad antitumor activity shown in immunocompetent models sensitive or resistant to immune checkpoint blockade

Activating innate immunity against breast cancer

Activating innate immunity against breast cancer

Silverback Therapeutics’ SBT6050 shows promise in HER2-expressing tumors

Clinical Trials

Good news from HARMONY

Good news from HARMONY

ACADIA’s pimavanserin halts trial at interim analysis after meeting primary endpoint

Full steam ahead in FSHD

Full steam ahead in FSHD

Fulcrum advances losmapimod into Phase 2b trial

Riding success to autoimmune disease

Riding success to autoimmune disease

Moderna follows clinical validation of systemic delivery with two more development candidates

Codexis and Nestlé Health Science team up

Codexis and Nestlé Health Science team up

Companies look to advance GI therapeutic candidate CDX-7108

A competitor for Cosentyx

A competitor for Cosentyx

AbbVie and Boehringer Ingelheim's Skyrizi showed superiority to Novartis' Cosentyx in Phase 3 trial of plaque psoriasis

Contract Services

Trial success a priority for new alliance

Trial success a priority for new alliance

Syneos Health and AiCure announce partnership to optimize patient engagement

Change continues for CDMOs

Change continues for CDMOs

Capstone Headwaters report highlights increased growth, transactions in pharmaceutical outsourcing

Providing better service for vesicles analysis

Providing better service for vesicles analysis

Exosomics implements NanoFCM’s NanoAnalyzer at its Siena site

Deepening DMPK at Sygnature

Deepening DMPK at Sygnature

Company development also bolsters subsidiary’s kidney disease and fibrosis capabilities

Diagnostics

Analysis pairs up with immunotherapy

Analysis pairs up with immunotherapy

Shimadzu and Providence Cancer Institute team up to advance cancer immunotherapy research

Further into oncology and NGS

Further into oncology and NGS

NeoGenomics acquires oncology operation from Human Longevity for $37 million

Why wait?

Why wait?

Bio-Rad’s ddPCR technology provides faster, more accurate diagnoses

Advancing genomics

Advancing genomics

Illumina announces new sequencing system, partnership with Roche and a software suite to accelerate genomics adoption

Finding mutations, matching treatments

Finding mutations, matching treatments

Clinical trial indicates that blood test beats biopsies for breast cancer

Research & Development

Ras, Raf and recall

Ras, Raf and recall

Scripps Research team uncovers the genes that play a role in cementing experiences as long-term memories

New uses for Ryanodex

New uses for Ryanodex

Eagle and UPenn explore drug's potential to treat Alzheimer’s

The benefits of B cells

The benefits of B cells

Multiple studies point to B cells’ role in promoting anti-tumor immunity

Cracking the code of gene regulation

Cracking the code of gene regulation

Queen's University Belfast researchers look into how and why only certain DNA elements are chosen to regulate gene expression, and how this predisposes us to diseases

Feature

News Roundup: Coronavirus

News Roundup: Coronavirus

Recent news about research into diagnosis and treatment of the Wuhan coronavirus

Focus Feature: Tox Screening

Focus Feature: Tox Screening

A looks at recent action in the world of toxicology screening, including recent news and a Q&A with Taconic Biosciences

Analytica 2020 Show Preview: Aiming for excellence in analysis

Analytica 2020 Show Preview: Aiming for excellence in analysis

Science meets industry at the biennial Analytica conference, which will be held in Munich March 31 through April 03

Commentary

Commentary: Learning from the Wuhan coronavirus

Commentary: Learning from the Wuhan coronavirus

Commentary: Learning from the Wuhan coronavirus

Collaboration leads the way to better understanding of pathogen

Everything is too expensive: Part 2

Everything is too expensive: Part 2

Peter Kissinger follows up his December column with a "part 2" talking about the cost-benefit ratio in the life sciences

Editor's Focus

Editor’s Focus: Breaking down the outbreak

Editor’s Focus: Breaking down the outbreak

The Wuhan coronavirus is something to be concerned about, but like every outbreak we need to keep things in perspective
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