February 2019 Volume 15, Issue 2

Volume 15, Issue 2 | February 2019

February 2019

In this Issue

Business & Government Policy

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When giants collide

Bristol-Myers Squibb aims to acquire Celgene for a hefty $74 billion
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Lilly to acquire Loxo for $8B

Among other benefits, addition of Loxo will broaden scope of Lilly’s oncology portfolio into precision medicines
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On the cutting edge

A roundup of instrumentation, software and other tools and technology news
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Eye on the FDA

Agency launches new digital tool

Discovery

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RBBP6 may hold the key

Insight into how Ebola, Dengue and Zika viruses interact with human cells opens the door for treatments
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Gilead and Scholar Rock target fibrosis

The partners will focus on the potential of TGFβ inhibitors
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Free resource against infections

New data intended to ‘spark’ much-needed antibiotic research
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Cryptographic protocol aids collaboration in drug discovery

Neural network that securely finds potential drugs could encourage large-scale pooling of sensitive data
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XtalPi to accelerate platform development

Closing of $46-million Series B-1 extension will aid access to AI tools

Diagnostics

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Stopping the silent killer

New liquid biopsy technique a powerful diagnostic tool for early detection of ovarian, endometrial cancer
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United front against frontotemporal degeneration

ADDF, AFTD announce funding plans for biomarkers of dementia
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Non-invasive options for NASH

GENFIT and LabCorp team up in licensing agreement for a NASH diagnostic test
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A breath of fresh (diagnostic) air

PAN Cancer trial launches to evaluate Owlstone Medical’s Breath Biopsy platform for cancer diagnosis
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Machine learning could aid sepsis care

Model predicts whether patients need a change in therapy

Feature

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Focus Feature on Artificial Intelligence: 'Intelligence' in the discovery

AI is becoming far less of a buzzword and much more of a practical and necessary reality
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Society of Toxicology 2019 Show Preview: Baltimore-bound for toxicology

Annual meeting and ToxExpo to unite over 300 toxicology-related companies and organizations, with more than 6,000 attendees over three da

Editor's Focus

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Editor's Focus: Your 2019 intelligence briefing

Well, if nothing else, artificial intelligence may be about to surpass the intelligence of many of today's politicians; let's talk a little bit about both

Commentary

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Revisiting the approach to Y2K, looking out to Y2K+20

We have seen information technology anxiety run rampant in the past (with Y2K); today's worries about cyber security, fake news, autonomous robotics and artificial intelligence are nothing new...but they are worth noting nonetheless
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Guest Commentary: Opportunities for personalized cancer immunotherapy directed by immune-profiling

There are currently three main approaches to characterizing the immune landscape of solid tumors: transcriptional profiling, single-cell cytometric analyses and histology; each of these disciplines brings its own benefits and, with rapid technological advances, powerful datasets are now achievable.

Research & Development

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Amping up AMPK research

New model lets scientists activate health-promoting enzyme AMPK at any time, in any tissue
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Blocking out genetic noise

Team trains computing program to filter out benign variants to better identify pathogenic mutations
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Elsevier launches Entellect

New platform designed to unlock value by creating AI-ready life-sciences data

Preclinical

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Synthetic gene promoter targets hemophilia

Novel approach appears to circumvent inhibitors to factor VIII in early clinical studies
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Q BioMed partners with SRI International

Collaboration provides Q BioMed with formulation and preclinical expertise to progress QBM-001 for pediatric nonverbal disorder in autism
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Wasp venom shows potential as an antibiotic

Altered peptides from the venom can kill bacteria but are nontoxic to human cells
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It’s all in the presentation

A roundup of recent preclinical data presentations

Clinical Trials

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Data support SYNB1020 in cirrhosis

Phase 1 clinical trial of SYNB1020 in healthy volunteers demonstrated safety, clearance and proof of mechanism
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A new force against cancer

Nanobiotix and MD Anderson Cancer Center collaborate on new product
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A guy thing

Simple, reversible male contraceptive minimizes side effects
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Breast case scenarios

Atossa’s male Phase 1 study of Endoxifen for breast health starts well; Phase 2 for women with MBD continues
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The trials of AI

Machine learning and other tools seeing increased interest for clinical studies

Contract Services

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Biotech boost

Dedicated PAREXEL division helps emerging companies
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Imaging initiative

RadMD, AG Mednet combine specialties to offer new imaging support for clinical trials
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Shore invests $6M in healthcare AI data startup

H1 says it is the first to arm biopharmas with live data insights
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Driving gene therapy with nonviral vectors 

Learn why nonviral vectors are on the rise in gene therapy development.
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Milestone: Leapfrogging to quantitative, high throughput protein detection and analysis

Researchers continuously push the boundaries of what’s possible with protein analysis tools.
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Advancing immuno-oncology research with cellular assays

Explore critical insights into immunogenicity and immunotoxicity assays for cancer therapies.
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