February 2018 Volume 14, Issue 2

Volume 14, Issue 2 | February 2018

February 2018

In this Issue

Diagnostics

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Agendia’s MammaPrint prepares for Europe

Company teams up with Institut Curie for kit validation
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Breast cancer biomarkers

Immune checkpoint blockade therapy could be promising
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East meets West for MoU

BGI, Hummingbird Diagnostics join hands for early diagnosis of Alzheimer’s and Parkinson's diseases
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Illumina partners with KingMed

Companies aim to develop NGS technology for Chinese FDA approval
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Diagnostic technology goes 3D

New research study demonstrates applicability of VisionGate’s Cell-CT platform

Discovery

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Microbial mysteries

TSRI unlocks secrets of deadly virus and finds clues to cancer treatment in bacteria
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Crohn’s and Parkinson’s in cahoots?

Gene mutations found in Crohn’s patients suggest possible link with Parkinson’s disease
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The new ‘IT’ thing in drug discovery

Global pharma drug discovery IT solutions to reach $5.3B by 2020, says Frost & Sullivan
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Muscling up on stem cells

Researchers track muscle stem cell dynamics in response to injury and aging
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A new way to treat diabetes

Follicum identifies receptors in insulin-producing cells for potential new class of diabetes drugs

Research & Development

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A meeting of metabolomics

Biocrates Life Sciences acquires Metanomics Health
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Potentially powerful cancer biomarker identified

Protein expression may predict risk of colorectal cancer recurrence
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Making the ‘best’ better

Media system extends lifespan of functional neurons to advance neurodegenerative research
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MVA-VLP platform is ‘MVP’ in new collaboration

GeoVax, Vaxeal will apply GeoVax’s MVA-VLP platform to generate cancer vaccines
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Agilent collaborates with USC

Team-up aims to facilitate transformational biomedical science and engineering research

Feature

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SOT/ToxExpo Show Preview: Texas welcomes back SOT

The Society of Toxicology revisits sunny San Antonio five years later
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Special Focus on Cancer Research News: An eye on immunotherapeutics

A roundup of recent research efforts to advance immuno-oncology efforts

Special Reports

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Special Report on Cardiovascular Disease: Breaking the non-code

Heart scientists look to small RNAs for clues to pathology and treatment

Editor's Focus

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Editor’s focus: Whose business is it, anyway?

In the healthcare realm, outside forces with money, resources and will are moving in to take charge of costs and efficiencies. The question is, will they really be able to make a difference, and how long before we see similar activity in pharma and biotech?

Business & Government Policy

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Patent Docs: Supreme Court expansion of patent-limiting doctrine puts branded drugs at risk

The significance of the legal decision to pharmaceutical products and the patents that protect their exclusivity arises from the aspect of the decision relating to exhaustion cause by foreign sales
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Celgene to acquire Juno for $9 billion

Acquisition will add novel scientific platform and manufacturing expertise to Celgene’s research and operational capabilities
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Generation Bio launches into genetic medicine

Startup aims to develop truly drug-like genetic medicines based on its GeneWave technology
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On the cutting edge

A roundup of instrumentation, software and other tools and technology news
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Vical restructures to focus on HSV-2 and antifungal programs

Company expects to report that it ended 2017 with cash and investments of approximately $60M to $65M

Contract Services

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What’s in a name?

Two contract services providers change their monikers as part of strategic shifts
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Room to grow

Rho builds new headquarters to meet needs of growing contract research operations
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A new COO and a bigger footprint

Cromos looks to establish a more global presence

Preclinical

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Pioneering solid-tumor cancer program

NANOBIOTIX partners with Providence Cancer Institute for immunotherapeutic preclinical research
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New subsidiary, new AAV gene therapies

The most promising novel treatment, Tamid-001, may stop hereditary ocular disease
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Test-driving a potential autism drug

Research shows drug candidate NitroSynapsin helps correct signaling imbalances in animal models
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Saniona selects preclinical candidate

New potential therapy resides in GABAA α2/α3 program for neuropathic pain and chronic itching

Clinical Trials

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A second candidate against MDR infections

Achaogen boasts positive top-line results from first clinical trial of oral antibacterial C-Scape
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Two big hits for Agios

Presentations showcase company’s development in cancer treatment
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Beating back the bipolar blues

Primary endpoint met in study of patients treated with cariprazine for acute bipolar I depression
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Hunter syndrome slips Shire’s net

Shire announces disappointing top-line results for SHP609 trial in children with Hunter syndrome and cognitive impairment

Commentary

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Guest Commentary: Turning text into insights

There is too much published research for a person to keep up with; fortunately, with the right technology, such as text mining tools, researchers can overcome this challenge
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Catching the wave in 2018

Peter Kissinger takes some time to answer a few questions from readers of his column
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A 3D rendering of motor neurons lit up with blue, purple, orange, and green coloring showing synapses against a black background.

Improving ALS research with pluripotent stem cell-derived models 

Discover new advancements in modeling amyotrophic lateral sclerosis.

Automating 3D cell selection

Discover precise automated tools for organoid and spheroid handling. 
An illustration of the tumor microenvironment, showing cancer cells, T cells, and nanoparticles interacting within a complex biological system

A closer look at the tumor microenvironment 

New technologies are allowing researchers to delve deeper into the complex tumor landscape.
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