February 2017- Volume 13, Issue 2

In this Issue

Discovery

Agilent and Transcriptic team up

Agilent and Transcriptic team up

Aim is to provide a broad, convenient solution for synthetic and discovery biology research

Another feather for Watson’s hat

Another feather for Watson’s hat

IBM teams up with Pfizer to use Watson for cancer drug discovery

A ‘crystal’ clear look at CCR2

A ‘crystal’ clear look at CCR2

Skaggs team offers new structural biology insight into promising inflammation target

Global drug discovery technologies trends

Global drug discovery technologies trends

The Global Drug Discovery Technologies Market is poised to grow at a compound annual growth rate of around 12.2 percent over the next decade

Putting the BiTE on cancer

Putting the BiTE on cancer

Amgen and Immatics combine expertise to develop next-generation, T cell-engaging bispecific immunotherapies

Research & Development

Minimizing memory loss

Minimizing memory loss

TSRI scientists uncover potential clues regarding Alzheimer’s disease

Exploring immuno-oncology potential

Exploring immuno-oncology potential

Alliance between Pieris Pharmaceuticals and Servier aimed at bispecific therapeutics

Targeting TIGIT

Targeting TIGIT

Compugen discloses its cancer immunotherapy program that seeks to combine TIGIT and CGEN-15029 work

A flick of the switch

A flick of the switch

Newly discovered ‘off-switches’ for CRISPR-Cas9 could mean safer, more specific gene editing

Business & Government Policy

Breaking down gluten

Breaking down gluten

Takeda helps PvP tackle celiac disease

Fighting the rise of antimicrobial resistance

Fighting the rise of antimicrobial resistance

U.K.’s Auspherix sets stage for new direction in developing antibacterials

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

NCI launches new drug formulary

NCI launches new drug formulary

Effort is intended to help expedite use of agents in clinical trials

Preclinical

A Kinoid collaboration

A Kinoid collaboration

Neovacs, Sunnybrook Research Institute unite for immunotherapy preclinical development and proof of concept

Masitinib on muscles

Masitinib on muscles

Compound may protect muscles and nerves in amyotrophic lateral sclerosis sufferers

Progress on prostate and breast with AEB3103

Progress on prostate and breast with AEB3103

Aeglea BioTherapeutics finds product candidate effective in slowing cancer growth

Skin in the game

Skin in the game

Preclinical data show Novan’s SB414 could be promising for treating psoriasis

Diagnostics

Liquid biopsy in the palm of your hand

Liquid biopsy in the palm of your hand

Two Pore Guys and UCSF collaborate on study with first handheld device for cancer monitoring

Videssa victory

Videssa victory

Provista Diagnostics reveals positive findings for its blood-based breast cancer test

Clinical Genomics launches Colvera

Clinical Genomics launches Colvera

Blood-based test is intended for early detection of colorectal cancer

Clinical Trials

‘Unusual’ antibody

‘Unusual’ antibody

Bird Rock Bio starts first-in-human clinical trial for namacizumab, enters two collaborations

Addressing lactose intolerance via the microbiome

Addressing lactose intolerance via the microbiome

Ritter Pharmaceuticals publishes Phase 2a lactose intolerance clinical trial data

Optimistic news for FCS and FPL patients

Optimistic news for FCS and FPL patients

Akcea and Ionis announce auspicious results from COMPASS study

Good news for GEN-003

Good news for GEN-003

Six-month results for genital herpes therapy are positive; Genocea on course to begin Phase 3 in Q4

Contract Services

Enamine and Pcovery extend discovery collaboration

Enamine and Pcovery extend discovery collaboration

A key focus is discovery of new drugs for the treatment of invasive fungal infections

ERT acquires Exco InTouch

ERT acquires Exco InTouch

Merging of two companies opens up possibilities in the ‘bring your own device’ market

ClinTec wins scale-up business award

ClinTec wins scale-up business award

In addition, company CEO was a finalist for entrepreneur award

Feature

Cancer Research News Focus: A tour of the developing cancer landscape

Cancer Research News Focus: A tour of the developing cancer landscape

From reproducibility to genomic data sets to the best countries for research, plus a look at what some specific companies and institutions are doing

Society of Toxicology Show Preview: SOT heads to Baltimore

Society of Toxicology Show Preview: SOT heads to Baltimore

After eight years, the Society of Toxicology brings its annual meeting back to ‘Charm City’

Editor's Focus

Cannabinoid research speeding up its pace

Cannabinoid research speeding up its pace

In this month's editorial, I studiously avoided almost all of the easy and very tempting puns related to marijuana because the truth is that cannabis-related research is serious business these days; in fact, it long has been, but now it is getting more respect and attention

Commentary

The irreproducibility of published science

The irreproducibility of published science

Yes, there are issues and problems around the issue of reproducibility in scientific studies, and they need to be addressed; at the same time, there are reasons this area is challenging, and there is no reason to denigrate science overall because of it

Guest Commentary: Validating antibodies-- The good, the bad and the necessary

Guest Commentary: Validating antibodies-- The good, the bad and the necessary

Although there are no universally accepted guidelines to ensure that antibodies have been properly validated, there are steps that can (and should) be taken by both the antibody industry and the researchers who use antibodies to improve that situation

Q&A

Q&A: The importance of oxygen in cell cultures

Q&A: The importance of oxygen in cell cultures

Panasonic Healthcare’s Carl Radosevich talks oxygenation and cell culturing with DDNews
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