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December 2022/January 2023

A photograph of three glass blown structures. Each structure depicts a blue tumor being attacked by purple cytotoxic T cells in 3D.

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A photograph of Alex Ritter standing outside smiling.

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With videos of dramatic cancer cell deaths and unflagging T cell attacks, Alex Ritter studies how immune cells and tumors battle with microscopic precision.

Glass T cells kill cancer in living color

A radiologist examines an MRI scan of a patient’s brain.

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A clear-eyed view of illness emerges from Alzheimer&#39;s disease.

The ecology of disease

Editor's Focus

A white mouse on a blue running wheel stands nose to nose with another mouse that is outside the wheel.

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A cross section of pink skeletal muscle fibers.

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A man in a blue jacket is running through the mountains at sunrise.

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Exercise-induced molecules may inspire the next generation of neuroprotective drugs.

Exercise mimicking drugs boost brain health

A woman in a purple jacket and black headband blows her nose in a tissue while standing in a snowy field. 

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A headshot of John Halliwill wearing a green polo shirt.  

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A woman wearing a blue tank top, black shorts, sneakers, and a breathing rate monitoring device runs on a treadmill in a lab. A man wearing a white lab coat observes. 

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Histamine is released in response to physical activity, but that doesn&rsquo;t mean that humans are allergic to exercise. John Halliwill investigates the intriguing role of histamine in exercise.

Are antihistamines antiworkout?

Exercise Physiology

A headshot of Bob Hancock wearing a blue and white striped button-up shirt. 

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A white bottle spills colorful pills in the shape of a question mark on a yellow surface. 

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A headshot of Rolf Müller wearing a blue and red checked button-up shirt. 

Researchers seeking new classes of chemical compounds or pursuing alternative antibacterial approaches make their cases.

Two sides to overcoming antibiotic resistance

Two scanning electron microscope images of bacteria are shown. In the top image, the bacteria are intact and colored orange over a blue background. In the bottom image, a bacterial cell looks red and shriveled up with green DNA coming out of it.

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James Collins leans against a lab bench in his laboratory at the Massachusetts Institute of Technology.

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Cesar de la Fuente smiles in a blue shirt in a photo taken outside.  

Advances in computation and artificial intelligence help scientists identify novel antibiotics encoded within human proteins and create new ones.

Mining human proteins for hidden antibiotics

Antibiotics

Allan Doctor wears a pink button-up shirt, lab coat, and glasses and holds up and looks at a rack of falcon tubes containing a red liquid. 

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A test tube filled with blood spills onto a white surface. 

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A headshot of Shinji Takeoka wearing a pinstripe button-up shirt, gray blazer, and glasses in front of greenery (left). A headshot of Hiromi Sakai wearing a light blue button-up shirt, a black blazer, and glasses in front of a bookshelf (right). 

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The arm of a person dressed in a camouflage shirt  holds an inverted glass bottle containing a top layer of white powder and a bottom layer of orange liquid connecting to a transfusion tube. 

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The massive hemoglobin protein of the tiny earthworm functions without a red blood cell. 

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Four soldiers in camouflaged uniforms in a desert. One lays on their stomach, one kneels over another laying on their back, and one shields the sun with their hand and watches as a helicopter approaches.

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A headshot of Anirban Sen Gupta wearing a black sweater, gray blazer, and glasses against a blue background. 

Synthetic platelets can mimic the adhesion, aggregation, and stabilization mechanisms of the blood’s natural clotting process. 

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The ErythroMer artificial red blood cell recapitulates the cell’s tunable oxygen affinity, iron reduction system, and nitric oxide diffusion barrier. 

Facing donor shortages and storage limitations, researchers are developing synthetic red blood cells, platelets, and plasma and combining them into artificial blood.

Making blood in the lab

Hematology

Surface rendering of two interacting proteins (green and peach) bound together by a small molecule ligand at their interface, illustrating a protein-ligand binding event.

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Salad Technologies

Learn how molecular dynamics, AI-aided design, and structural insights combine to reshape how therapeutic proteins are created, validated, and optimized.

Computational approaches to drug design

Compendium

Stem cells are shown as clear, purple, and blue spheres against a dark blue and black background.

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Diagram showing how patient-derived somatic cells are reprogrammed into iPSCs using Yamanaka factors and then differentiated into specialized cell types such as neurons, cardiomyocytes, and hepatocytes.

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BPS Bioscience

Human-relevant, ready-to-use stem cell models are reshaping drug discovery, toxicity testing, and personalized medicine.

Improving translational research with iPSC-derived cells

Articles

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Characterizing lipid nanoparticles for RNA therapeutic development

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Inotiv

Integrated multiomics and advanced nanoparticle analytics are improving how researchers perform RNA delivery, increasing therapeutic success.

December 2022/January 2023 Volume 18, Issue 12