December 2022/January 2023- Volume 18, Issue 12

In this Issue

Editor's Focus

A radiologist examines an MRI scan of a patient’s brain.

The ecology of disease

The ecology of disease

A clear-eyed view of illness emerges from Alzheimer's disease.
A photograph of three glass blown structures. Each structure depicts a blue tumor being attacked by purple cytotoxic T cells in 3D.

Glass T cells kill cancer in living color

Glass T cells kill cancer in living color

With videos of dramatic cancer cell deaths and unflagging T cell attacks, Alex Ritter studies how immune cells and tumors battle with microscopic precision.

Exercise Physiology

A cross section of pink skeletal muscle fibers.

Exercise mimicking drugs boost brain health

Exercise mimicking drugs boost brain health

Exercise-induced molecules may inspire the next generation of neuroprotective drugs.
A woman in a purple jacket and black headband blows her nose in a tissue while standing in a snowy field.

Are antihistamines antiworkout?

Are antihistamines antiworkout?

Histamine is released in response to physical activity, but that doesn’t mean that humans are allergic to exercise. John Halliwill investigates the intriguing role of histamine in exercise.

Antibiotics

A white bottle spills colorful pills in the shape of a question mark on a yellow surface.

Two sides to overcoming antibiotic resistance

Two sides to overcoming antibiotic resistance

Researchers seeking new classes of chemical compounds or pursuing alternative antibacterial approaches make their cases.
Two scanning electron microscope images of bacteria are shown. In the top image, the bacteria are intact and colored orange over a blue background. In the bottom image, a bacterial cell looks red and shriveled up with green DNA coming out of it.

Mining human proteins for hidden antibiotics

Mining human proteins for hidden antibiotics

Advances in computation and artificial intelligence help scientists identify novel antibiotics encoded within human proteins and create new ones.

Hematology

A test tube filled with blood spills onto a white surface.

Making blood in the lab

Making blood in the lab

Facing donor shortages and storage limitations, researchers are developing synthetic red blood cells, platelets, and plasma and combining them into artificial blood.
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• Volume 18 • Issue 12 • December 2022/January 2023

December 2022/January 2023

December 2022/January 2023 issue