January 2021 Volume 17, Issue 1

December 2020/January 2021 issue

Volume 17, Issue 1 | January 2021

December 2020/January 2021

In this Issue

Preclinical

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Deep learning for drug design

Metabolite Translator assesses safety of novel compounds
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Passage makes progress against rare lysosomal storage disease

Preclinical data show injection of optimized AAV vector may correct gangliosidosis
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Good news for PolyPEPI-SCoV-2

PepTC reports positive preclinical results for peptide vaccine

Exosomes to the rescue in cancer

Codiak demonstrates potential of engineered exosomes to stimulate targeted, antitumor immunity

Tools & Technology

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Machine learning improves tandem MS

Purdue researchers apply machine learning concepts to create a new mass spec method
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Reaction rules

Retrosynthesis tool automates molecule making
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Q&A: A jump to the next step in sequencing

Jumpcode details how its CRISPRclean tech unites NGS and CRISPR/Cas editing

Clinical Trials

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Good news to wake up to

Jazz reports promising results for Xywav in adults with rare sleep disorder
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Putting RWD and NHD up against placebo

Results from cTAP indicate both could augment or replace placebo controls in DMD clinical trials
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Psoriasis progress

EDP1815 Phase 1b data shared at EADV Virtual
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Atossa shares Phase 1 results for AT-301

Preliminary results show safety and tolerability of AT-301 nasal spray for COVID-19

Diagnostics

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Heavy lifting with HULLK

APIS, University of Virginia hope to leverage HULLK lncRNA as a prostate cancer biomarker

Tracing cancer with tattoo ink

USC researchers say tattoo inks and food dyes could help improve cancer detection
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Functional MRI: The next tool for mental health?

Researchers develop an algorithm for predicting medication response in mental health patients  
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Five minutes, one answer

A breath test to rapidly diagnose COVID-19 infection may be on the way from imec

Discovery

Bugs making drugs: Harnessing bacteria to treat disease

Bacteria engineered to produce therapeutics fill a niche for patients with unmet medical needs.
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Choosing CRISPR in the fight against SARS-CoV-2

Study demonstrates how changes in human genes can reduce SARS-CoV-2 infection
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Braking macrophages

Molecule mimics naturally occurring protein to prevent overreaction
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Getting answers on GABAergic neurons

UTSA researchers find breakthrough discovery on brain cortex functionality
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Arming the industry to fight AMR

The AMR Action Fund seeks to support antibiotic candidates in massive industry-philanthropic alliance

Special Reports

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Beyond Vaccines

Researchers are seeking antivirals to protect the unprotected

Feature

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SLAS prepares for digital event to “Ignite 2021 with a spark”

Get a look at what the Society for Laboratory Automation and Screening’s virtual annual meeting has to offer

Commentary

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Goodbye DDNews; hello DDN

With our first issue of 2021, we have lots of great changes to bring you
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The easy way in

Wide adoption and regimen compliance are two reasons for easier administration, whether with COVID or schizophrenia

Editor's Focus

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Out of order: A season of hope

Sharing insights, stories, progress, and hope on fighting infectious diseases
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Learn how to distinguish true extracellular vesicles from similarly sized particles using affinity capture and immunofluorescence.
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Explore how a needs-driven approach to electronic laboratory notebook selection can improve data integrity, reproducibility, and scientific continuity.
Scientist weighing a laboratory sample using a four-decimal analytical balance in a quality control setting.
Learn the fundamental weighing principles and operational controls that support reliable sample preparation.
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