January 2021 Volume 17, Issue 1

December 2020/January 2021 issue

Volume 17, Issue 1 | January 2021

December 2020/January 2021

In this Issue

Preclinical

Deep learning for drug design

Metabolite Translator assesses safety of novel compounds
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Passage makes progress against rare lysosomal storage disease

Preclinical data show injection of optimized AAV vector may correct gangliosidosis

Good news for PolyPEPI-SCoV-2

PepTC reports positive preclinical results for peptide vaccine

Exosomes to the rescue in cancer

Codiak demonstrates potential of engineered exosomes to stimulate targeted, antitumor immunity

Tools & Technology

Machine learning improves tandem MS

Purdue researchers apply machine learning concepts to create a new mass spec method
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Reaction rules

Retrosynthesis tool automates molecule making
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Q&A: A jump to the next step in sequencing

Jumpcode details how its CRISPRclean tech unites NGS and CRISPR/Cas editing

Clinical Trials

Good news to wake up to

Jazz reports promising results for Xywav in adults with rare sleep disorder

Putting RWD and NHD up against placebo

Results from cTAP indicate both could augment or replace placebo controls in DMD clinical trials

Psoriasis progress

EDP1815 Phase 1b data shared at EADV Virtual

Atossa shares Phase 1 results for AT-301

Preliminary results show safety and tolerability of AT-301 nasal spray for COVID-19

Diagnostics

Heavy lifting with HULLK

APIS, University of Virginia hope to leverage HULLK lncRNA as a prostate cancer biomarker

Tracing cancer with tattoo ink

USC researchers say tattoo inks and food dyes could help improve cancer detection

Functional MRI: The next tool for mental health?

Researchers develop an algorithm for predicting medication response in mental health patients  

Five minutes, one answer

A breath test to rapidly diagnose COVID-19 infection may be on the way from imec

Discovery

Bugs making drugs: Harnessing bacteria to treat disease

Bacteria engineered to produce therapeutics fill a niche for patients with unmet medical needs.

Choosing CRISPR in the fight against SARS-CoV-2

Study demonstrates how changes in human genes can reduce SARS-CoV-2 infection

Braking macrophages

Molecule mimics naturally occurring protein to prevent overreaction

Getting answers on GABAergic neurons

UTSA researchers find breakthrough discovery on brain cortex functionality

Arming the industry to fight AMR

The AMR Action Fund seeks to support antibiotic candidates in massive industry-philanthropic alliance

Special Reports

Beyond Vaccines

Researchers are seeking antivirals to protect the unprotected

Feature

SLAS prepares for digital event to “Ignite 2021 with a spark”

Get a look at what the Society for Laboratory Automation and Screening’s virtual annual meeting has to offer

Commentary

Goodbye DDNews; hello DDN

With our first issue of 2021, we have lots of great changes to bring you

The easy way in

Wide adoption and regimen compliance are two reasons for easier administration, whether with COVID or schizophrenia

Editor's Focus

Out of order: A season of hope

Sharing insights, stories, progress, and hope on fighting infectious diseases
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Reliable fluid biomarkers strategies for clinical neuroscience research

Reliable fluid biomarkers strategies for clinical neuroscience research

Explore how validated fluid biomarker assays advance clinical research for neurological diseases.
Laboratorian with a white coat and blue gloves pipettes green liquid into a beaker with multicolored liquids in beakers and tubes in the blue-tinged, sterile laboratory background.

Discovering cutting-edge nitrosamine analysis in pharmaceuticals

New tools help researchers detect and manage harmful nitrosamine impurities in drugs such as monoclonal antibodies.
A starry night sky reflected over calm water, symbolizing the discovery of hidden patterns in complex systems.

Technology Guide: Spatial biology techniques

Discover essential strategies and expert insights to navigate the expanding world of spatial biology.
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