December 2019- Volume 15, Issue 12
In this Issue
Preclinical
The immune reset
The immune reset
New data from Magenta Therapeutics support CD45-ADC in its ability to rebuild the immune system
Accelerating a novel glioma therapeutic
Accelerating a novel glioma therapeutic
PhoreMost and Sentinel expand collaboration to progress PLK1 inhibitor through preclinical and IND-enabling studies
Compugen presents preclinical data for COM902
Compugen presents preclinical data for COM902
Data support potential clinical use as a cancer immunotherapy treatment
A step forward with MultiTEP
A step forward with MultiTEP
Alzheimer’s vaccine targeted against pathological Tau protein generates significant antibodies in mice
Printing vascularized skin
Printing vascularized skin
Researchers have developed a way to 3D print vascularized, living skin
Business & Government Policy
Harnessing T cells
Harnessing T cells
Adaptate Biotherapeutics spins out from U.K.-based GammaDelta Therapeutics to accelerate development of therapeutic antibodies
On the cutting edge
On the cutting edge
A roundup of instrumentation, software and other tools and technology news
Lonza commits to Cryoport
Lonza commits to Cryoport
Partnership to provide fully integrated delivery solutions for handling of tissues
Contract Services
PPD expands capabilities in early development
PPD expands capabilities in early development
Among the additions are significant neuroscience and ethno-bridging expertise
Driving drug discovery
Driving drug discovery
Sygnature Discovery boosts high-throughput screening capabilities
Diagnostics
Recognizing diagnostic capabilities
Recognizing diagnostic capabilities
Shuwen Biotech designated as an International Cooperation Base for Medical diagnostic technologies
Breathing easier with diagnostic options
Breathing easier with diagnostic options
Owlstone to contribute Breath Biopsy to 3TR to improve disease management across seven immune-mediated diseases
Dynamic combo
Dynamic combo
Promega, Merck team up on MSI diagnostic for use with Keytruda
Mologic, Sherlock combine forces for point-of-care tests
Mologic, Sherlock combine forces for point-of-care tests
The companies hope to develop flexible new instrument-free diagnostics
Clinical Trials
KarXT shows promise for acute psychosis in schizophrenia
KarXT shows promise for acute psychosis in schizophrenia
Karuna Therapeutics candidate, which works on the muscarinic receptor, meets primary endpoint in Phase 2 trial
Calcification control
Calcification control
Orphan drug focuses on calcification disorders in renal disease
A focus on fusions
A focus on fusions
Merus reports clinical data for patients with NRG1 fusions in their cancers
Combo shows promise
Combo shows promise
Antibody-drug conjugate for breast cancer gets good marks in HER2CLIMB top-line analysis
Research & Development
Model makers
Model makers
A trio of agreements expands industry work in disease and organ modeling
Plectin’s biomarker role grows
Plectin’s biomarker role grows
University of Houston researchers find protein on cancer stem cells
Dragonfly Therapeutics collaborates with AbbVie
Dragonfly Therapeutics collaborates with AbbVie
Dragonfly and its TriNKET platform to develop drug candidates for autoimmune disorders and oncology; AbbVie will have exclusive options to license some of Dragonfly’s NK cell engager immunotherapies
Discovery
Pushing neuroscience discovery forward
Pushing neuroscience discovery forward
Metrion Biosciences and LifeArc extend ion channel drug discovery collaboration
Modeling mantle cell
Modeling mantle cell
Researchers have created a new discovery model for mantle cell lymphoma
Simulating success
Simulating success
Turbine secures seed funding to expand the potential of simulation-first drug discovery
Progressing epitranscriptomic drug candidates
Progressing epitranscriptomic drug candidates
Gotham Therapeutics establishes advanced oncology profiling cascade with ProQinase
Commentary
Everything is too expensive
Everything is too expensive
Drug prices may be too expensive, but some of the answers being touted might not be the best ones, says DDNews columnist Peter Kissinger, who shares some of his thoughts of the pros and cons of various notions
Publishers’ commentary: A peek into the future
Publishers’ commentary: A peek into the future
The publishers of DDNews give you a look at special features in store for the coming calendar year
Feature
Cancer Research News Focus Feature: Oncology--Stem to stern
Cancer Research News Focus Feature: Oncology--Stem to stern
A look at gastroesophageal, gastric and colorectal cancer progress, as well as other recent news of oncology research breakthroughs
SLAS 2020 Show Preview: SLAS in the sun
SLAS 2020 Show Preview: SLAS in the sun
The Society for Laboratory Automation and Screening heads to San Diego for SLAS 2020
Special Reports
Special Report on Liver Disease: The phantom menace
Special Report on Liver Disease: The phantom menace
In NASH, researchers battle a largely invisible threat, and in this feature you will get a look into how they are trying to overcome the challenges of that
