December 2019- Volume 15, Issue 12

In this Issue

Diagnostics

Breathing easier with diagnostic options

Breathing easier with diagnostic options

Owlstone to contribute Breath Biopsy to 3TR to improve disease management across seven immune-mediated diseases

Dynamic combo

Dynamic combo

Promega, Merck team up on MSI diagnostic for use with Keytruda

Recognizing diagnostic capabilities

Recognizing diagnostic capabilities

Shuwen Biotech designated as an International Cooperation Base for Medical diagnostic technologies

Discovery

Modeling mantle cell

Modeling mantle cell

Researchers have created a new discovery model for mantle cell lymphoma

Pushing neuroscience discovery forward

Pushing neuroscience discovery forward

Metrion Biosciences and LifeArc extend ion channel drug discovery collaboration

Simulating success

Simulating success

Turbine secures seed funding to expand the potential of simulation-first drug discovery

Progressing epitranscriptomic drug candidates

Progressing epitranscriptomic drug candidates

Gotham Therapeutics establishes advanced oncology profiling cascade with ProQinase

Business & Government Policy

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

Harnessing T cells

Harnessing T cells

Adaptate Biotherapeutics spins out from U.K.-based GammaDelta Therapeutics to accelerate development of therapeutic antibodies

Lonza commits to Cryoport

Lonza commits to Cryoport

Partnership to provide fully integrated delivery solutions for handling of tissues

Research & Development

Model makers

Model makers

A trio of agreements expands industry work in disease and organ modeling

Plectin’s biomarker role grows

Plectin’s biomarker role grows

University of Houston researchers find protein on cancer stem cells

Dragonfly Therapeutics collaborates with AbbVie

Dragonfly Therapeutics collaborates with AbbVie

Dragonfly and its TriNKET platform to develop drug candidates for autoimmune disorders and oncology; AbbVie will have exclusive options to license some of Dragonfly’s NK cell engager immunotherapies


Preclinical

A step forward with MultiTEP

A step forward with MultiTEP

Alzheimer’s vaccine targeted against pathological Tau protein generates significant antibodies in mice

The immune reset

The immune reset

New data from Magenta Therapeutics support CD45-ADC in its ability to rebuild the immune system

Compugen presents preclinical data for COM902

Compugen presents preclinical data for COM902

Data support potential clinical use as a cancer immunotherapy treatment

Accelerating a novel glioma therapeutic

Accelerating a novel glioma therapeutic

PhoreMost and Sentinel expand collaboration to progress PLK1 inhibitor through preclinical and IND-enabling studies

Printing vascularized skin

Printing vascularized skin

Researchers have developed a way to 3D print vascularized, living skin

Clinical Trials

Combo shows promise

Combo shows promise

Antibody-drug conjugate for breast cancer gets good marks in HER2CLIMB top-line analysis

A focus on fusions

A focus on fusions

Merus reports clinical data for patients with NRG1 fusions in their cancers

Calcification control

Calcification control

Orphan drug focuses on calcification disorders in renal disease

KarXT shows promise for acute psychosis in schizophrenia

KarXT shows promise for acute psychosis in schizophrenia

Karuna Therapeutics candidate, which works on the muscarinic receptor, meets primary endpoint in Phase 2 trial

Contract Services

Driving drug discovery

Driving drug discovery

Sygnature Discovery boosts high-throughput screening capabilities

PPD expands capabilities in early development

PPD expands capabilities in early development

Among the additions are significant neuroscience and ethno-bridging expertise

Special Reports

Special Report on Liver Disease: The phantom menace

Special Report on Liver Disease: The phantom menace

In NASH, researchers battle a largely invisible threat, and in this feature you will get a look into how they are trying to overcome the challenges of that

Feature

SLAS 2020 Show Preview: SLAS in the sun

SLAS 2020 Show Preview: SLAS in the sun

The Society for Laboratory Automation and Screening heads to San Diego for SLAS 2020

Cancer Research News Focus Feature: Oncology--Stem to stern

Cancer Research News Focus Feature: Oncology--Stem to stern

A look at gastroesophageal, gastric and colorectal cancer progress, as well as other recent news of oncology research breakthroughs

Commentary

Publishers’ commentary: A peek into the future

Publishers’ commentary: A peek into the future

The publishers of DDNews give you a look at special features in store for the coming calendar year

Everything is too expensive

Everything is too expensive

Drug prices may be too expensive, but some of the answers being touted might not be the best ones, says DDNews columnist Peter Kissinger, who shares some of his thoughts of the pros and cons of various notions
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